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Douglas R Houston
Douglas R Houston
Senior Lecturer in Computational Biochemistry, University of Edinburgh
Adresse e-mail validée de ed.ac.uk - Page d'accueil
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Crystal structure and binding properties of the Serratia marcescens chitin-binding protein CBP21
G Vaaje-Kolstad, DR Houston, AHK Riemen, VGH Eijsink, ...
Journal of Biological Chemistry 280 (12), 11313-11319, 2005
3452005
Structure of human chitotriosidase: implications for specific inhibitor design and function of mammalian chitinase-like lectins
F Fusetti, H Von Moeller, D Houston, HJ Rozeboom, BW Dijkstra, RG Boot, ...
Journal of Biological Chemistry 277 (28), 25537-25544, 2002
2952002
Consensus docking: improving the reliability of docking in a virtual screening context
DR Houston, MD Walkinshaw
Journal of chemical information and modeling 53 (2), 384-390, 2013
2572013
Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes
DR Houston, AD Recklies, JC Krupa, DMF Van Aalten
Journal of Biological Chemistry 278 (32), 30206-30212, 2003
1822003
Structure-based exploration of cyclic dipeptide chitinase inhibitors
DR Houston, B Synstad, VGH Eijsink, MJR Stark, IM Eggleston, ...
Journal of medicinal chemistry 47 (23), 5713-5720, 2004
1792004
Oligopeptide signaling through TbGPR89 drives trypanosome quorum sensing
F Rojas, E Silvester, J Young, R Milne, M Tettey, DR Houston, ...
Cell 176 (1), 306-317. e16, 2019
1342019
Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases
FV Rao, DR Houston, RG Boot, JMFG Aerts, M Hodkinson, DJ Adams, ...
Chemistry & biology 12 (1), 65-76, 2005
1312005
High-resolution structures of a chitinase complexed with natural product cyclopentapeptide inhibitors: mimicry of carbohydrate substrate
DR Houston, K Shiomi, N Arai, S Ōmura, MG Peter, A Turberg, B Synstad, ...
Proceedings of the National Academy of Sciences 99 (14), 9127-9132, 2002
1262002
Crystal structures of allosamidin derivatives in complex with human macrophage chitinase
FV Rao, DR Houston, RG Boot, JMFG Aerts, S Sakuda, DMF Van Aalten
Journal of Biological Chemistry 278 (22), 20110-20116, 2003
962003
Structure of the D142N mutant of the family 18 chitinase ChiB from Serratia marcescens and its complex with allosamidin
G Vaaje-Kolstad, DR Houston, FV Rao, MG Peter, B Synstad, ...
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1696 (1), 103-111, 2004
832004
Inhibition of the ERCC1–XPF structure-specific endonuclease to overcome cancer chemoresistance
EM McNeil, KR Astell, AM Ritchie, S Shave, DR Houston, P Bakrania, ...
DNA repair 31, 19-28, 2015
772015
The cyclic dipeptide CI-4 [cyclo-(l-Arg-d-Pro)] inhibits family 18 chitinases by structural mimicry of a reaction intermediate
DR Houston, I Eggleston, B SYNSTAD, VGH Eijsink, DMF AALTEN
Biochemical Journal 368 (1), 23-27, 2002
722002
Artemisinin resistance in rodent malaria-mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking
G Henriques, A Martinelli, L Rodrigues, K Modrzynska, R Fawcett, ...
Malaria journal 12, 1-15, 2013
692013
Interactions of a family 18 chitinase with the designed inhibitor HM508 and its degradation product, chitobiono-δ-lactone
G Vaaje-Kolstad, A Vasella, MG Peter, C Netter, DR Houston, ...
Journal of Biological Chemistry 279 (5), 3612-3619, 2004
682004
Interactions of a family 18 chitinase with the designed inhibitor HM508 and its degradation product, chitobiono-δ-lactone
G Vaaje-Kolstad, A Vasella, MG Peter, C Netter, DR Houston, ...
Journal of Biological Chemistry 279 (5), 3612-3619, 2004
682004
Intrinsic lipid binding activity of ATG 16L1 supports efficient membrane anchoring and autophagy
LJ Dudley, AG Cabodevilla, AN Makar, M Sztacho, T Michelberger, ...
The EMBO journal 38 (9), e100554, 2019
622019
Rapid discovery and structure–activity relationships of pyrazolopyrimidines that potently suppress breast cancer cell growth via SRC kinase inhibition with exceptional …
C Fraser, JC Dawson, R Dowling, DR Houston, JT Weiss, AF Munro, ...
Journal of medicinal chemistry 59 (10), 4697-4710, 2016
602016
Hetero‐trans‐β‐glucanase, an enzyme unique to Equisetum plants, functionalizes cellulose
TJ Simmons, KE Mohler, C Holland, F Goubet, L Franková, DR Houston, ...
The Plant Journal 83 (5), 753-769, 2015
562015
Identification and Characterization of a Protein-tyrosine Phosphatase in Leishmania
M Nascimento, WW Zhang, A Ghosh, DR Houston, AM Berghuis, M Olivier, ...
Journal of biological chemistry 281 (47), 36257-36268, 2006
532006
Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity
AA Makarov, J Zou, DR Houston, C Spanos, AS Solovyova, ...
Nature communications 10 (1), 3056, 2019
522019
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