Hector Keun

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Jeremy K NicholsonDirector, Australian National Phenome Center, Murdoch Univ. and Imperial College LondonAdresse e-mail validée de murdoch.edu.au
Elaine HolmesMurdoch University & Imperial College LondonAdresse e-mail validée de imperial.ac.uk
Tim EbbelsProfessor of Biomedical Data Science, Imperial College LondonAdresse e-mail validée de imperial.ac.uk
Henrik AnttiDepartment of Chemsitry, Umeå University, SwedenAdresse e-mail validée de chem.umu.se
Rachel CavillAssistant Professor, University of MaastrichtAdresse e-mail validée de maastrichtuniversity.nl
Jacob BundyImperial College LondonAdresse e-mail validée de imperial.ac.uk
Gabriel ValbuenaUniversity of OxfordAdresse e-mail validée de well.ox.ac.uk
Léa MaitreAssistant Research Professor, ISGlobal, SpainAdresse e-mail validée de isglobal.org
Griffin JLUniversity of CambridgeAdresse e-mail validée de cam.ac.uk
Agapios SachinidisProfessor of PhysiologyAdresse e-mail validée de uni-koeln.de
Ralf HerwigGroup Leader, Max Planck Institute for molecular Genetics, BerlinAdresse e-mail validée de molgen.mpg.de
Justin StebbingImperial CollegeAdresse e-mail validée de imperial.ac.uk
Paul JenningsVrije Universiteit AmsterdamAdresse e-mail validée de vu.nl
Dennie G.A.J. HebelsMaastricht UniversityAdresse e-mail validée de maastrichtuniversity.nl
Ian D WilsonImperial College, LondonAdresse e-mail validée de imperial.ac.uk
Soterios A. KyrtopoulosNational Hellenic Research Foundation, Institute of Chemical BiologyAdresse e-mail validée de eie.gr
Dr Andrew W NichollsHead of Bioimaging, GlaxoSmithKlineAdresse e-mail validée de gsk.com
domenico palliISPRO-EpidemiologiaAdresse e-mail validée de ispro.toscana.it
Eric Chun Yong ChanProfessor (Department of Pharmacy, Faculty of Science), National University of SingaporeAdresse e-mail validée de nus.edu.sg
David SpurgeonCentre for Ecology and HydrologyAdresse e-mail validée de ceh.ac.uk

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Hector Keun

Professor of Biochemistry, Imperial College London

Adresse e-mail validée de imperial.ac.uk - Page d'accueil

metabolic profiling toxicology tumour metabolism NMR spectroscopy pattern recognition


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Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts O Beckonert, HC Keun, TMD Ebbels, J Bundy, E Holmes, JC Lindon, ... Nature protocols 2 (11), 2692, 2007	2112	2007
Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project JC Lindon, JK Nicholson, E Holmes, H Antti, ME Bollard, H Keun, ... Toxicology and applied pharmacology 187 (3), 137-146, 2003	520	2003
Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass … ECY Chan, PK Koh, M Mal, PY Cheah, KW Eu, A Backshall, R Cavill, ... Journal of proteome research 8 (1), 352-361, 2009	505	2009
High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues O Beckonert, M Coen, HC Keun, Y Wang, TMD Ebbels, E Holmes, ... Nature protocols 5 (6), 1019-1032, 2010	392	2010
Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA A Kamburov, R Cavill, TMD Ebbels, R Herwig, HC Keun Bioinformatics 27 (20), 2917-2918, 2011	356	2011
The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements JC Lindon, HC Keun, TMD Ebbels, JMT Pearce, E Holmes, JK Nicholson Future Medicine Ltd 6 (7), 691-699, 2005	322	2005
Analytical reproducibility in 1H NMR-based metabonomic urinalysis HC Keun, TMD Ebbels, H Antti, ME Bollard, O Beckonert, G Schlotterbeck, ... Chemical research in toxicology 15 (11), 1380-1386, 2002	319	2002
The human early-life exposome (HELIX): project rationale and design M Vrijheid, R Slama, O Robinson, L Chatzi, M Coen, P Van den Hazel, ... Environmental health perspectives 122 (6), 535-544, 2014	316	2014
Summary recommendations for standardization and reporting of metabolic analyses Nature biotechnology 23 (7), 833-838, 2005	295	2005
Impact of analytical bias in metabonomic studies of human blood serum and plasma O Teahan, S Gamble, E Holmes, J Waxman, JK Nicholson, C Bevan, ... Analytical chemistry 78 (13), 4307-4318, 2006	283	2006
Cryogenic probe 13C NMR spectroscopy of urine for metabonomic studies HC Keun, O Beckonert, JL Griffin, C Richter, D Moskau, JC Lindon, ... Analytical chemistry 74 (17), 4588-4593, 2002	245	2002
Improved analysis of multivariate data by variable stability scaling: application to NMR-based metabolic profiling HC Keun, TMD Ebbels, H Antti, ME Bollard, O Beckonert, E Holmes, ... Analytica chimica acta 490 (1-2), 265-276, 2003	224	2003
Interlaboratory reproducibility of a targeted metabolomics platform for analysis of human serum and plasma AP Siskos, P Jain, W Römisch-Margl, M Bennett, D Achaintre, Y Asad, ... Analytical chemistry 89 (1), 656-665, 2017	213	2017
Metabolomics in toxicology and preclinical research T Ramirez, M Daneshian, H Kamp, FY Bois, MR Clench, M Coen, ... Altex 30 (2), 209, 2013	211	2013
Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues Y Wang, ME Bollard, H Keun, H Antti, O Beckonert, TM Ebbels, JC Lindon, ... Analytical biochemistry 323 (1), 26-32, 2003	210	2003
Metabonomic modeling of drug toxicity HC Keun Pharmacology & therapeutics 109 (1-2), 92-106, 2006	208	2006
Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach TMD Ebbels, HC Keun, OP Beckonert, ME Bollard, JC Lindon, E Holmes, ... Journal of proteome research 6 (11), 4407-4422, 2007	204	2007
NMR-based metabonomic toxicity classification: hierarchical cluster analysis and k-nearest-neighbour approaches O Beckonert, ME Bollard, TMD Ebbels, HC Keun, H Antti, E Holmes, ... Analytica Chimica Acta 490 (1-2), 3-15, 2003	176	2003
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models ME Dumas, SP Wilder, MT Bihoreau, RH Barton, JF Fearnside, K Argoud, ... Nature genetics 39 (5), 666-672, 2007	175	2007
Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles HC Keun, TMD Ebbels, ME Bollard, O Beckonert, H Antti, E Holmes, ... Chemical Research in Toxicology 17 (5), 579-587, 2004	165	2004

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