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Hector Keun
Hector Keun
Professor of Biochemistry, Imperial College London
Adresse e-mail validée de imperial.ac.uk - Page d'accueil
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Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
O Beckonert, HC Keun, TMD Ebbels, J Bundy, E Holmes, JC Lindon, ...
Nature protocols 2 (11), 2692, 2007
21122007
Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project
JC Lindon, JK Nicholson, E Holmes, H Antti, ME Bollard, H Keun, ...
Toxicology and applied pharmacology 187 (3), 137-146, 2003
5202003
Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass …
ECY Chan, PK Koh, M Mal, PY Cheah, KW Eu, A Backshall, R Cavill, ...
Journal of proteome research 8 (1), 352-361, 2009
5052009
High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues
O Beckonert, M Coen, HC Keun, Y Wang, TMD Ebbels, E Holmes, ...
Nature protocols 5 (6), 1019-1032, 2010
3922010
Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA
A Kamburov, R Cavill, TMD Ebbels, R Herwig, HC Keun
Bioinformatics 27 (20), 2917-2918, 2011
3562011
The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements
JC Lindon, HC Keun, TMD Ebbels, JMT Pearce, E Holmes, JK Nicholson
Future Medicine Ltd 6 (7), 691-699, 2005
3222005
Analytical reproducibility in 1H NMR-based metabonomic urinalysis
HC Keun, TMD Ebbels, H Antti, ME Bollard, O Beckonert, G Schlotterbeck, ...
Chemical research in toxicology 15 (11), 1380-1386, 2002
3192002
The human early-life exposome (HELIX): project rationale and design
M Vrijheid, R Slama, O Robinson, L Chatzi, M Coen, P Van den Hazel, ...
Environmental health perspectives 122 (6), 535-544, 2014
3162014
Summary recommendations for standardization and reporting of metabolic analyses
Nature biotechnology 23 (7), 833-838, 2005
2952005
Impact of analytical bias in metabonomic studies of human blood serum and plasma
O Teahan, S Gamble, E Holmes, J Waxman, JK Nicholson, C Bevan, ...
Analytical chemistry 78 (13), 4307-4318, 2006
2832006
Cryogenic probe 13C NMR spectroscopy of urine for metabonomic studies
HC Keun, O Beckonert, JL Griffin, C Richter, D Moskau, JC Lindon, ...
Analytical chemistry 74 (17), 4588-4593, 2002
2452002
Improved analysis of multivariate data by variable stability scaling: application to NMR-based metabolic profiling
HC Keun, TMD Ebbels, H Antti, ME Bollard, O Beckonert, E Holmes, ...
Analytica chimica acta 490 (1-2), 265-276, 2003
2242003
Interlaboratory reproducibility of a targeted metabolomics platform for analysis of human serum and plasma
AP Siskos, P Jain, W Römisch-Margl, M Bennett, D Achaintre, Y Asad, ...
Analytical chemistry 89 (1), 656-665, 2017
2132017
Metabolomics in toxicology and preclinical research
T Ramirez, M Daneshian, H Kamp, FY Bois, MR Clench, M Coen, ...
Altex 30 (2), 209, 2013
2112013
Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues
Y Wang, ME Bollard, H Keun, H Antti, O Beckonert, TM Ebbels, JC Lindon, ...
Analytical biochemistry 323 (1), 26-32, 2003
2102003
Metabonomic modeling of drug toxicity
HC Keun
Pharmacology & therapeutics 109 (1-2), 92-106, 2006
2082006
Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach
TMD Ebbels, HC Keun, OP Beckonert, ME Bollard, JC Lindon, E Holmes, ...
Journal of proteome research 6 (11), 4407-4422, 2007
2042007
NMR-based metabonomic toxicity classification: hierarchical cluster analysis and k-nearest-neighbour approaches
O Beckonert, ME Bollard, TMD Ebbels, HC Keun, H Antti, E Holmes, ...
Analytica Chimica Acta 490 (1-2), 3-15, 2003
1762003
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
ME Dumas, SP Wilder, MT Bihoreau, RH Barton, JF Fearnside, K Argoud, ...
Nature genetics 39 (5), 666-672, 2007
1752007
Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles
HC Keun, TMD Ebbels, ME Bollard, O Beckonert, H Antti, E Holmes, ...
Chemical Research in Toxicology 17 (5), 579-587, 2004
1652004
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