Ronald A. DePinho
Ronald A. DePinho
MD Anderson
Adresse e-mail validée de mdanderson.org
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Malignant astrocytic glioma: genetics, biology, and paths to treatment
FB Furnari, T Fenton, RM Bachoo, A Mukasa, JM Stommel, A Stegh, ...
Genes & development 21 (21), 2683-2710, 2007
24712007
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
MA Blasco, HW Lee, MP Hande, E Samper, PM Lansdorp, RA DePinho, ...
Cell 91 (1), 25-34, 1997
24151997
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
TG Boulton, SH Nye, DJ Robbins, NY Ip, E Radzlejewska, ...
Cell 65 (4), 663-675, 1991
23111991
Hepatocellular carcinoma pathogenesis: from genes to environment
PA Farazi, RA DePinho
Nature Reviews Cancer 6 (9), 674-687, 2006
20822006
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
RJ Shaw, KA Lamia, D Vasquez, SH Koo, N Bardeesy, RA DePinho, ...
Science 310 (5754), 1642-1646, 2005
20042005
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
J Pomerantz, N Schreiber-Agus, NJ Liégeois, A Silverman, L Alland, ...
Cell 92 (6), 713-723, 1998
18411998
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
RJ Shaw, M Kosmatka, N Bardeesy, RL Hurley, LA Witters, RA DePinho, ...
Proceedings of the National Academy of Sciences 101 (10), 3329-3335, 2004
18162004
Role of the INK4a locus in tumor suppression and cell mortality
M Serrano, HW Lee, L Chin, C Cordon-Cardo, D Beach, RA DePinho
Cell 85 (1), 27-37, 1996
18131996
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
JJL Jacobs, K Kieboom, S Marino, RA DePinho, M Van Lohuizen
Nature 397 (6715), 164-168, 1999
17961999
International network of cancer genome projects
International Cancer Genome Consortium
Nature 464 (7291), 993, 2010
17732010
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
Z Tothova, R Kollipara, BJ Huntly, BH Lee, DH Castrillon, DE Cullen, ...
Cell 128 (2), 325-339, 2007
15412007
Longevity, stress response, and cancer in aging telomerase-deficient mice
KL Rudolph, S Chang, HW Lee, M Blasco, GJ Gottlieb, C Greider, ...
Cell 96 (5), 701-712, 1999
14811999
HDAC2 negatively regulates memory formation and synaptic plasticity
JS Guan, SJ Haggarty, E Giacometti, JH Dannenberg, N Joseph, J Gao, ...
Nature 459 (7243), 55-60, 2009
14392009
Pancreatic cancer biology and genetics
N Bardeesy, RA DePinho
Nature Reviews Cancer 2 (12), 897-909, 2002
14182002
Essential role of mouse telomerase in highly proliferative organs
HW Lee, MA Blasco, GJ Gottlieb, JW Horner, CW Greider, RA DePinho
Nature 392 (6676), 569-574, 1998
14131998
Malignant glioma: genetics and biology of a grave matter
EA Maher, FB Furnari, RM Bachoo, DH Rowitch, DN Louis, WK Cavenee, ...
Genes & development 15 (11), 1311-1333, 2001
14032001
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
H Ying, AC Kimmelman, CA Lyssiotis, S Hua, GC Chu, ...
Cell 149 (3), 656-670, 2012
13222012
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
J Son, CA Lyssiotis, H Ying, X Wang, S Hua, M Ligorio, RM Perera, ...
Nature 496 (7443), 101-105, 2013
12422013
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
SE Artandi, S Chang, SL Lee, S Alson, GJ Gottlieb, L Chin, RA DePinho
Nature 406 (6796), 641-645, 2000
12292000
Genetics and biology of pancreatic ductal adenocarcinoma
AF Hezel, AC Kimmelman, BZ Stanger, N Bardeesy, RA DePinho
Genes & development 20 (10), 1218-1249, 2006
11892006
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