| Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery IA Khalil, K Kogure, H Akita, H Harashima Pharmacological reviews 58 (1), 32-45, 2006 | 1512 | 2006 |
| High density of octaarginine stimulates macropinocytosis leading to efficient intracellular trafficking for gene expression IA Khalil, K Kogure, S Futaki, H Harashima Journal of Biological Chemistry 281 (6), 3544-3551, 2006 | 441 | 2006 |
| Octaarginine-and octalysine-modified nanoparticles have different modes of endosomal escape A El-Sayed, IA Khalil, K Kogure, S Futaki, H Harashima Journal of Biological Chemistry 283 (34), 23450-23461, 2008 | 219 | 2008 |
| Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery IA Khalil, K Kogure, S Futaki, S Hama, H Akita, M Ueno, H Kishida, ... Gene therapy 14 (8), 682-689, 2007 | 206 | 2007 |
| Quantitative three-dimensional analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene delivery system using confocal laser scanning microscopy H Akita, R Ito, IA Khalil, S Futaki, H Harashima Molecular Therapy 9 (3), 443-451, 2004 | 189 | 2004 |
| Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation IA Khalil, S Futaki, M Niwa, Y Baba, N Kaji, H Kamiya, H Harashima Gene therapy 11 (7), 636-644, 2004 | 188 | 2004 |
| Multi-layered nanoparticles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process H Akita, A Kudo, A Minoura, M Yamaguti, IA Khalil, R Moriguchi, ... Biomaterials 30 (15), 2940-2949, 2009 | 164 | 2009 |
| Octaarginine-modified liposomes: enhanced cellular uptake and controlled intracellular trafficking IA Khalil, K Kogure, S Futaki, H Harashima International journal of pharmaceutics 354 (1-2), 39-48, 2008 | 124 | 2008 |
| Positively charged polyethylenimines enhance nasal absorption of the negatively charged drug, low molecular weight heparin T Yang, A Hussain, S Bai, IA Khalil, H Harashima, F Ahsan Journal of controlled release 115 (3), 289-297, 2006 | 119 | 2006 |
| Octaarginine-and pH sensitive fusogenic peptide-modified nanoparticles for liver gene delivery IA Khalil, Y Hayashi, R Mizuno, H Harashima Journal of controlled release 156 (3), 374-380, 2011 | 89 | 2011 |
| Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape A El-Sayed, T Masuda, I Khalil, H Akita, H Harashima Journal of controlled release 138 (2), 160-167, 2009 | 86 | 2009 |
| Cell penetrating peptide-mediated systemic siRNA delivery to the liver Y Hayashi, J Yamauchi, IA Khalil, K Kajimoto, H Akita, H Harashima International journal of pharmaceutics 419 (1-2), 308-313, 2011 | 81 | 2011 |
| Cellular uptake and subsequent intracellular trafficking of R8-liposomes introduced at low temperature A Iwasa, H Akita, I Khalil, K Kogure, S Futaki, H Harashima Biochimica et Biophysica Acta (BBA)-Biomembranes 1758 (6), 713-720, 2006 | 80 | 2006 |
| Lung‐endothelium‐targeted nanoparticles based on a pH‐sensitive lipid and the GALA peptide enable robust gene silencing and the regression of metastatic lung cancer MM Abd Elwakil, IA Khalil, YHA Elewa, K Kusumoto, Y Sato, N Shobaki, ... Advanced functional materials 29 (18), 1807677, 2019 | 64 | 2019 |
| Ultra-small lipid nanoparticles encapsulating sorafenib and midkine-siRNA selectively-eradicate sorafenib-resistant hepatocellular carcinoma in vivo MA Younis, IA Khalil, YHA Elewa, Y Kon, H Harashima Journal of Controlled Release 331, 335-349, 2021 | 59 | 2021 |
| Novel lipid combination for delivery of plasmid DNA to immune cells in the spleen S Kimura, IA Khalil, YHA Elewa, H Harashima Journal of Controlled Release 330, 753-764, 2021 | 51 | 2021 |
| A multifunctional lipid-based nanodevice for the highly specific codelivery of sorafenib and midkine siRNA to hepatic cancer cells MA Younis, IA Khalil, MM Abd Elwakil, H Harashima Molecular pharmaceutics 16 (9), 4031-4044, 2019 | 51 | 2019 |
| Lipid nanoparticles for cell-specific in vivo targeted delivery of nucleic acids IA Khalil, MA Younis, S Kimura, H Harashima Biological and Pharmaceutical Bulletin 43 (4), 584-595, 2020 | 50 | 2020 |
| Synergism between a cell penetrating peptide and a pH-sensitive cationic lipid in efficient gene delivery based on double-coated nanoparticles IA Khalil, S Kimura, Y Sato, H Harashima Journal of controlled release 275, 107-116, 2018 | 50 | 2018 |
| Optimization of siRNA delivery to target sites: issues and future directions IA Khalil, Y Yuma, H Harashima Expert Opinion on Drug Delivery, 2018 | 44 | 2018 |
