Matthew Brecher
Matthew Brecher
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Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme
JM White, SE Delos, M Brecher, K Schornberg
Critical reviews in biochemistry and molecular biology 43 (3), 189-219, 2008
Influenza virus pleiomorphy characterized by cryoelectron tomography
A Harris, G Cardone, DC Winkler, JB Heymann, M Brecher, JM White, ...
Proceedings of the National Academy of Sciences 103 (50), 19123-19127, 2006
The primed ebolavirus glycoprotein (19-kilodalton GP1, 2): sequence and residues critical for host cell binding
D Dube, MB Brecher, SE Delos, SC Rose, EW Park, KL Schornberg, ...
Journal of virology 83 (7), 2883-2891, 2009
Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change
M Brecher, KL Schornberg, SE Delos, ML Fusco, EO Saphire, JM White
Journal of virology 86 (1), 364-372, 2012
Effects of Zika Virus Strain and Aedes Mosquito Species on Vector Competence.
KLD Ciota AT, Bialosuknia SM, Zink SD, Brecher M, Ehrbar DJ, Morrissette MN
Emerging Infectious Diseases 23 (7), 1110-1117, 2017
Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction
Z Li, M Brecher, YQ Deng, J Zhang, S Sakamuru, B Liu, R Huang, ...
Cell research 27 (8), 1046-1064, 2017
A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease
M Brecher, Z Li, B Liu, J Zhang, CA Koetzner, A Alifarag, SA Jones, Q Lin, ...
PLoS pathogens 13 (5), e1006411, 2017
Novel broad spectrum inhibitors targeting the flavivirus methyltransferase
M Brecher, H Chen, B Liu, NK Banavali, SA Jones, J Zhang, Z Li, ...
PLoS One 10 (6), e0130062, 2015
Erythrosin B is a potent and broad-spectrum orthosteric inhibitor of the flavivirus NS2B-NS3 protease
Z Li, S Sakamuru, R Huang, M Brecher, CA Koetzner, J Zhang, H Chen, ...
Antiviral research 150, 217-225, 2018
The flavivirus protease as a target for drug discovery
M Brecher, J Zhang, H Li
Virologica Sinica 28 (6), 326-336, 2013
DNA forms of arboviral RNA genomes are generated following infection in mosquito cell cultures
DK Nag, M Brecher, LD Kramer
Virology 498, 164-171, 2016
Identification and characterization of novel broad-spectrum inhibitors of the flavivirus methyltransferase
M Brecher, H Chen, Z Li, NK Banavali, SA Jones, J Zhang, LD Kramer, ...
ACS infectious diseases 1 (8), 340-349, 2015
Cysteines flanking the internal fusion peptide are required for the avian sarcoma/leukosis virus glycoprotein to mediate the lipid mixing stage of fusion with high efficiency
SE Delos, MB Brecher, Z Chen, DC Melder, MJ Federspiel, JM White
Journal of virology 82 (6), 3131-3134, 2008
Visualization of the two-step fusion process of the retrovirus avian sarcoma/leukosis virus by cryo-electron tomography
G Cardone, M Brecher, J Fontana, DC Winkler, C Butan, JM White, ...
Journal of virology 86 (22), 12129-12137, 2012
Coupling of conformational transitions in the N-terminal domain of the 51-kDa FK506-binding protein (FKBP51) near its site of interaction with the steroid receptor proteins
DM LeMaster, SM Mustafi, M Brecher, J Zhang, A Héroux, H Li, ...
Journal of Biological Chemistry 290 (25), 15746-15757, 2015
S-adenosyl-homocysteine is a weakly bound inhibitor for a flaviviral methyltransferase
H Chen, B Zhou, M Brecher, N Banavali, SA Jones, Z Li, J Zhang, D Nag, ...
PloS one 8 (10), e76900, 2013
Structural basis of conformational transitions in the active site and 80′ s loop in the FK506-binding protein FKBP12
SM Mustafi, M Brecher, J Zhang, H Li, DM Lemaster, G Hernández
Biochemical Journal 458 (3), 525-536, 2014
Refolding of a fully functional flavivirus methyltransferase revealed that S‐adenosyl methionine but not S‐adenosyl homocysteine is copurified with flavivirus methyltransferase
MB Brecher, Z Li, J Zhang, H Chen, Q Lin, B Liu, H Li
Protein Science 24 (1), 117-128, 2015
Extensive recoding of dengue virus type 2 specifically reduces replication in primate cells without gain-of-function in Aedes aegypti mosquitoes
CB Stauft, SH Shen, Y Song, O Gorbatsevych, E Asare, B Futcher, ...
PloS one 13 (9), e0198303, 2018
Pfit Is a Structurally Novel Crohn's Disease-Associated Superantigen
L Liu, H Chen, MB Brecher, Z Li, B Wei, B Nandi, J Zhang, H Ling, ...
PLoS pathogens 9 (12), e1003837, 2013
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