Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice M Citron, D Westaway, W Xia, G Carlson, T Diehl, G Levesque, ... Nature medicine 3 (1), 67, 1997 | 1849 | 1997 |
Propagation of tau pathology in a model of early Alzheimer's disease A de Calignon, M Polydoro, M Suárez-Calvet, C William, DH Adamowicz, ... Neuron 73 (4), 685-697, 2012 | 1513 | 2012 |
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695 MA Chishti, DS Yang, C Janus, AL Phinney, P Horne, J Pearson, ... Journal of Biological Chemistry 276 (24), 21562-21570, 2001 | 1193 | 2001 |
Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication SB Prusiner, M Scott, D Foster, KM Pan, D Groth, C Mirenda, M Torchia, ... Cell 63 (4), 673-686, 1990 | 1157 | 1990 |
Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration BR Hoover, MN Reed, J Su, RD Penrod, LA Kotilinek, MK Grant, R Pitstick, ... Neuron 68 (6), 1067-1081, 2010 | 1131 | 2010 |
Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques M Scott, D Foster, C Mirenda, D Serban, F Coufal, M Wälchli, M Torchia, ... Cell 59 (5), 847-857, 1989 | 947 | 1989 |
The relationship between Aβ and memory in the Tg2576 mouse model of Alzheimer's disease MA Westerman, D Cooper-Blacketer, A Mariash, L Kotilinek, ... Journal of Neuroscience 22 (5), 1858-1867, 2002 | 919 | 2002 |
Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L) M Ramsden, L Kotilinek, C Forster, J Paulson, E McGowan, K SantaCruz, ... Journal of Neuroscience 25 (46), 10637-10647, 2005 | 722 | 2005 |
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel RC Moore, IY Lee, GL Silverman, PM Harrison, R Strome, C Heinrich, ... Journal of molecular biology 292 (4), 797-817, 1999 | 694 | 1999 |
Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins KK Hsiao, DR Borchelt, K Olson, R Johannsdottir, C Kitt, W Yunis, S Xu, ... Neuron 15 (5), 1203-1218, 1995 | 675 | 1995 |
Distinct prion proteins in short and long scrapie incubation period mice D Westaway, PA Goodman, CA Mirenda, MP McKinley, GA Carlson, ... Cell 51 (4), 651-662, 1987 | 638 | 1987 |
Caspase activation precedes and leads to tangles A de Calignon, LM Fox, R Pitstick, GA Carlson, BJ Bacskai, ... Nature 464 (7292), 1201-1204, 2010 | 637 | 2010 |
Linkage of prion protein and scrapie incubation time genes GA Carlson, DT Kingsbury, PA Goodman, S Coleman, ST Marshall, ... Cell 46 (4), 503-511, 1986 | 491 | 1986 |
Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains P Markel, P Shu, C Ebeling, GA Carlson, DL Nagle, JS Smutko, KJ Moore Nature genetics 17 (3), 280, 1997 | 490 | 1997 |
Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family PW Kleyn, W Fan, SG Kovats, JJ Lee, JC Pulido, Y Wu, LR Berkemeier, ... Cell 85 (2), 281-290, 1996 | 476 | 1996 |
SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein C Iadecola, F Zhang, K Niwa, C Eckman, SK Turner, E Fischer, S Younkin, ... Nature neuroscience 2 (2), 157-161, 1999 | 474 | 1999 |
Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy TL Spires, JD Orne, K SantaCruz, R Pitstick, GA Carlson, KH Ashe, ... The American journal of pathology 168 (5), 1598-1607, 2006 | 453 | 2006 |
Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins D Westaway, SJ DeArmond, J Cayetano-Canlas, D Groth, D Foster, ... Cell 76 (1), 117-129, 1994 | 426 | 1994 |
Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein L Park, P Zhou, R Pitstick, C Capone, J Anrather, EH Norris, L Younkin, ... Proceedings of the National Academy of Sciences 105 (4), 1347-1352, 2008 | 367 | 2008 |
Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein K Niwa, K Kazama, L Younkin, SG Younkin, GA Carlson, C Iadecola American Journal of Physiology-Heart and Circulatory Physiology 283 (1 …, 2002 | 352 | 2002 |