Tim Ebbels
Tim Ebbels
Reader in Computational Bioinformatics, Imperial College London
Adresse e-mail validée de imperial.ac.uk - Page d'accueil
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Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
O Beckonert, HC Keun, TMD Ebbels, J Bundy, E Holmes, JC Lindon, ...
Nature protocols 2 (11), 2692-2703, 2007
17482007
Human metabolic phenotype diversity and its association with diet and blood pressure
E Holmes, RL Loo, J Stamler, M Bictash, IKS Yap, Q Chan, T Ebbels, ...
Nature 453 (7193), 396-400, 2008
10102008
Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project
JC Lindon, JK Nicholson, E Holmes, H Antti, ME Bollard, H Keun, ...
Toxicology and applied pharmacology 187 (3), 137-146, 2003
4772003
Proposed minimum reporting standards for data analysis in metabolomics
R Goodacre, D Broadhurst, AK Smilde, BS Kristal, JD Baker, R Beger, ...
Metabolomics 3 (3), 231-241, 2007
3832007
High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues
O Beckonert, M Coen, HC Keun, Y Wang, TMD Ebbels, E Holmes, ...
Nature protocols 5 (6), 1019-1032, 2010
3472010
Recursive Segment-Wise Peak Alignment of Biological 1H NMR Spectra for Improved Metabolic Biomarker Recovery
KA Veselkov, JC Lindon, TMD Ebbels, D Crockford, VV Volynkin, ...
Analytical chemistry 81 (1), 56-66, 2009
3092009
The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements
JC Lindon, HC Keun, TMD Ebbels, JMT Pearce, E Holmes, JK Nicholson
Future Medicine Ltd 6 (7), 691-699, 2005
3042005
Analytical reproducibility in 1H NMR-based metabonomic urinalysis
HC Keun, TMD Ebbels, H Antti, ME Bollard, O Beckonert, G Schlotterbeck, ...
Chemical research in toxicology 15 (11), 1380-1386, 2002
2912002
Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA
A Kamburov, R Cavill, TMD Ebbels, R Herwig, HC Keun
Bioinformatics 27 (20), 2917-2918, 2011
2552011
Optimized preprocessing of ultra-performance liquid chromatography/mass spectrometry urinary metabolic profiles for improved information recovery
KA Veselkov, LK Vingara, P Masson, SL Robinette, E Want, JV Li, ...
Analytical chemistry 83 (15), 5864-5872, 2011
2442011
Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues
Y Wang, ME Bollard, H Keun, H Antti, O Beckonert, TM Ebbels, JC Lindon, ...
Analytical biochemistry 323 (1), 26-32, 2003
1992003
Improved analysis of multivariate data by variable stability scaling: application to NMR-based metabolic profiling
HC Keun, TMD Ebbels, H Antti, ME Bollard, O Beckonert, E Holmes, ...
Analytica chimica acta 490 (1-2), 265-276, 2003
1982003
Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach
TMD Ebbels, HC Keun, OP Beckonert, ME Bollard, JC Lindon, E Holmes, ...
Journal of proteome research 6 (11), 4407-4422, 2007
1952007
Optimization and evaluation of metabolite extraction protocols for untargeted metabolic profiling of liver samples by UPLC-MS
P Masson, AC Alves, TMD Ebbels, JK Nicholson, EJ Want
Analytical Chemistry 82 (18), 7779-7786, 2010
1682010
NMR-based metabonomic toxicity classification: hierarchical cluster analysis and k-nearest-neighbour approaches
O Beckonert, ME Bollard, TMD Ebbels, HC Keun, H Antti, E Holmes, ...
Analytica Chimica Acta 490 (1-2), 3-15, 2003
1662003
Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles
HC Keun, TMD Ebbels, ME Bollard, O Beckonert, H Antti, E Holmes, ...
Chemical Research in Toxicology 17 (5), 579-587, 2004
1542004
The evolution of partial least squares models and related chemometric approaches in metabonomics and metabolic phenotyping
JM Fonville, SE Richards, RH Barton, CL Boulange, TMD Ebbels, ...
Journal of Chemometrics 24 (11‐12), 636-649, 2010
1492010
Opening up the" Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology
M Bictash, TM Ebbels, Q Chan, RL Loo, IKS Yap, IJ Brown, M De Iorio, ...
Journal of clinical epidemiology 63 (9), 970-979, 2010
1462010
Comparative metabonomics of differential hydrazine toxicity in the rat and mouse
ME Bollard, HC Keun, O Beckonert, TMD Ebbels, H Antti, AW Nicholls, ...
Toxicology and applied pharmacology 204 (2), 135-151, 2005
1462005
Urinary metabolic signatures of human adiposity
P Elliott, JM Posma, Q Chan, I Garcia-Perez, A Wijeyesekera, M Bictash, ...
Science translational medicine 7 (285), 285ra62-285ra62, 2015
1332015
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