Reactivity of the HIV-1 nucleocapsid protein p7 zinc finger domains from the perspective of density-functional theory AT Maynard, M Huang, WG Rice, DG Covell
Proceedings of the National Academy of Sciences 95 (20), 11578-11583, 1998
417 1998 Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins M Huang, A Maynard, JA Turpin, L Graham, GM Janini, DG Covell, ...
Journal of medicinal chemistry 41 (9), 1371-1381, 1998
183 1998 Reactivity of zinc finger cores: analysis of protein packing and electrostatic screening AT Maynard, DG Covell
Journal of the American Chemical Society 123 (6), 1047-1058, 2001
177 2001 Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers JA Turpin, Y Song, JK Inman, M Huang, A Wallqvist, A Maynard, ...
Journal of medicinal chemistry 42 (1), 67-86, 1999
147 1999 Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor LH Wang, XY Yang, X Zhang, K Mihalic, YX Fan, W Xiao, OMZ Howard, ...
Nature medicine 10 (1), 40-47, 2004
101 2004 Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function OMZ Howard, AK Shirakawa, JA Turpin, A Maynard, GJ Tobin, ...
Journal of Biological Chemistry 274 (23), 16228-16234, 1999
94 1999 Targeting the NS5A protein of HCV: an emerging option DG Cordek, JT Bechtel, AT Maynard, WM Kazmierski, CE Cameron
Drugs of the Future 36 (9), 691, 2011
60 2011 Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase A Maynard, RM Crosby, B Ellis, R Hamatake, Z Hong, BA Johns, ...
Journal of Medicinal Chemistry 57 (5), 1902-1913, 2014
56 2014 An Ab initio study of the relationship between nitroarene mutagenicity and electron affinity. AT Maynard, LG Pedersen, HS Posner, JD McKinney
Molecular pharmacology 29 (6), 629-636, 1986
56 1986 Novel spiroketal pyrrolidine GSK2336805 potently inhibits key hepatitis C virus genotype 1b mutants: from lead to clinical compound WM Kazmierski, A Maynard, M Duan, S Baskaran, J Botyanszki, R Crosby, ...
Journal of Medicinal Chemistry 57 (5), 2058-2073, 2014
54 2014 Design of N -Benzoxaborole Benzofuran GSK8175—Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor PY Chong, JB Shotwell, J Miller, DJ Price, A Maynard, C Voitenleitner, ...
Journal of Medicinal Chemistry 62 (7), 3254-3267, 2019
51 2019 A quantum dynamical study of CH overtones in fluoroform. II. Eigenstate analysis of the A Maynard, RE Wyatt, C Iung
The Journal of chemical physics 106 (23), 9483-9496, 1997
46 1997 A quantum dynamical study of CH overtones in fluoroform. I. A nine‐dimensional ab initio surface, vibrational spectra and dynamics AT Maynard, RE Wyatt, C Iung
The Journal of chemical physics 103 (19), 8372-8390, 1995
43 * 1995 Quantifying, visualizing, and monitoring lead optimization AT Maynard, CD Roberts
Journal of Medicinal Chemistry 59 (9), 4189-4201, 2016
33 2016 Small molecule inhibition of RAS/MAPK signaling ameliorates developmental pathologies of Kabuki Syndrome IC Tsai, K McKnight, SU McKinstry, AT Maynard, PL Tan, C Golzio, ...
Scientific reports 8 (1), 10779, 2018
31 2018 Inhibitors of ion channels BE Marron, PC Fritch, CJ Markworth, AT Maynard, NA Swain
US Patent 8,741,934, 2014
31 * 2014 Design and synthesis of spirocyclic compounds as HCV replication inhibitors by targeting viral NS4B protein VWF Tai, D Garrido, DJ Price, A Maynard, JJ Pouliot, Z Xiong, JW Seal III, ...
Bioorganic & medicinal chemistry letters 24 (10), 2288-2294, 2014
27 2014 Comparison of the specificity of interaction of cellular and viral zinc-binding domains with 2-mercaptobenzamide thioesters LMM Jenkins, SR Durell, AT Maynard, SJ Stahl, JK Inman, E Appella, ...
Journal of the American Chemical Society 128 (36), 11964-11976, 2006
25 2006 Matrix Isolation Infrared and ab Initio Study of the 1:1 Complexes of Bromocyclopropane with NH3 and (CH3 )3 N: Evidence for a Novel C−H···N Hydrogen Bond BL Bedell, L Goldfarb, ER Mysak, C Samet, A Maynard
The Journal of Physical Chemistry A 103 (23), 4572-4579, 1999
25 1999 Statistical tools for virtual screening JR Krumrine, AT Maynard, CL Lerman
Journal of medicinal chemistry 48 (23), 7477-7481, 2005
16 2005 
lee pedersenemeritus professor of chemistry, university of north carolina at chapel hillAdresse e-mail validée de ad.unc.edu
