Frank von Delft

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Coauteurs

Opher GileadiSGC, Karolinska InstituteAdresse e-mail validée de ki.se
Brian MarsdenCentre for Medicines Discovery & Kennedy Institute of RheumatologyAdresse e-mail validée de cmd.ox.ac.uk
Wen Hwa LeeAction Against AMD, SGC and University of OxfordAdresse e-mail validée de actionagainstamd.org
Tobias KrojerMAX IV LaboratoryAdresse e-mail validée de maxiv.lu.se
Stefan KnappUniversity of FrankfurtAdresse e-mail validée de pharmchem.uni-frankfurt.de
Ashley PikeCentre for Medicines Discovery - University of OxfordAdresse e-mail validée de cmd.ox.ac.uk
Tom L BlundellEmeritus Professor of Biochemistry, University of CambridgeAdresse e-mail validée de cam.ac.uk
Patrick M CollinsExscientiaAdresse e-mail validée de exscientia.co.uk
Joao Renato Carvalho MunizAssociate Professor, Physics Institute of Sao Carlos, University of Sao PauloAdresse e-mail validée de ifsc.usp.br
Oleg FedorovUniversity of OxfordAdresse e-mail validée de cmd.ox.ac.uk
Frank NiesenJohnson & JohnsonAdresse e-mail validée de its.jnj.com
Nicholas M PearceVrije Universiteit AmsterdamAdresse e-mail validée de vu.nl
Anthony BradleyExscientiaAdresse e-mail validée de exscientia.co.uk
Charlotte DeaneProfessor of Structural Bioinformatics, Oxford UniversityAdresse e-mail validée de stats.ox.ac.uk
Catrine JohanssonUniversity of Oxford and Karolinska InstituteAdresse e-mail validée de ndorms.ox.ac.uk
Grazyna KochanTeam LeaderAdresse e-mail validée de navarra.es
Cheryl ArrowsmithSenior Scientist, Princess Margaret Cancer Centre & Professor of Medical Biophysics, University of TorontoAdresse e-mail validée de uhnres.utoronto.ca
Panagis FilippakopoulosAssociate Professor, Oxford UniversityAdresse e-mail validée de sgc.ox.ac.uk
Declan A. DoyleUniversity of SouthamptonAdresse e-mail validée de soton.ac.uk
Michael McDonoughAtomic Resolution Consulting ABAdresse e-mail validée de atomic-resolution.com

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Frank von Delft

Principal Investigator: Protein Crystallography, SGC, Oxford University

Adresse e-mail validée de sgc.ox.ac.uk

Protein Crystallography Fragment-based approaches Crystallographic Computing Synchrotron radiation Robotics


Titre Trier par citations Trier par année Trier par titre	Citée par Citée par	Année
Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin L Pellegrini, DF Burke, F von Delft, B Mulloy, TL Blundell Nature 407 (6807), 1029-1034, 2000	905	2000
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease A Douangamath, D Fearon, P Gehrtz, T Krojer, P Lukacik, CD Owen, ... Nature communications 11 (1), 5047, 2020	350	2020
CCP4i2: the new graphical user interface to the CCP4 program suite L Potterton, J Agirre, C Ballard, K Cowtan, E Dodson, PR Evans, ... Acta Crystallographica Section D: Structural Biology 74 (2), 68-84, 2018	334	2018
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity SS Ng, KL Kavanagh, MA McDonough, D Butler, ES Pilka, BMR Lienard, ... Nature 448 (7149), 87-91, 2007	327	2007
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases P Canning, CDO Cooper, T Krojer, JW Murray, ACW Pike, A Chaikuad, ... Journal of Biological Chemistry 288 (11), 7803-7814, 2013	263	2013
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming G Kochan, T Krojer, D Harvey, R Fischer, L Chen, M Vollmar, F von Delft, ... Proceedings of the National Academy of Sciences 108 (19), 7745-7750, 2011	263	2011
Structures of ABCB10, a human ATP-binding cassette transporter in apo-and nucleotide-bound states CA Shintre, ACW Pike, Q Li, JI Kim, AJ Barr, S Goubin, L Shrestha, J Yang, ... Proceedings of the National Academy of Sciences 110 (24), 9710-9715, 2013	259	2013
Structure of the CaMKIIδ/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation P Rellos, ACW Pike, FH Niesen, E Salah, WH Lee, F Von Delft, S Knapp PLoS biology 8 (7), e1000426, 2010	258	2010
Rapid covalent-probe discovery by electrophile-fragment screening E Resnick, A Bradley, J Gan, A Douangamath, T Krojer, R Sethi, ... Journal of the American Chemical Society 141 (22), 8951-8968, 2019	199	2019
A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ... Nature communications 8 (1), 15123, 2017	193	2017
Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva A Chaikuad, I Alfano, G Kerr, CE Sanvitale, JH Boergermann, JT Triffitt, ... Journal of Biological Chemistry 287 (44), 36990-36998, 2012	185	2012
Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases D Chen, M Vollmar, MN Rossi, C Phillips, R Kraehenbuehl, D Slade, ... Journal of Biological Chemistry 286 (15), 13261-13271, 2011	174	2011
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ... Journal of medicinal chemistry 55 (14), 6639-6643, 2012	141	2012
The crystal structure of human GLRX5: iron–sulfur cluster co-ordination, tetrameric assembly and monomer activity C Johansson, AK Roos, SJ Montano, R Sengupta, P Filippakopoulos, ... Biochemical Journal 433 (2), 303-311, 2011	137	2011
A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP (2), an atypical bromodomain OB Cox, T Krojer, P Collins, O Monteiro, R Talon, A Bradley, O Fedorov, ... Chemical science 7 (3), 2322-2330, 2016	136	2016
Crystal structure of aspartate decarboxylase at 2.2 Å resolution provides evidence for an ester in protein self–processing A Albert, V Dhanaraj, U Genschel, G Khan, MK Ramjee, R Pulido, ... Nature structural biology 5 (4), 289-293, 1998	131	1998
Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A G Kochan, ES Pilka, F von Delft, U Oppermann, WW Yue Journal of molecular biology 388 (5), 997-1008, 2009	118	2009
The structural basis of ZMPSTE24-dependent laminopathies A Quigley, YY Dong, ACW Pike, L Dong, L Shrestha, G Berridge, ... Science 339 (6127), 1604-1607, 2013	116	2013
Ribosomal oxygenases are structurally conserved from prokaryotes to humans R Chowdhury, R Sekirnik, NC Brissett, T Krojer, C Ho, SS Ng, IJ Clifton, ... Nature 510 (7505), 422-426, 2014	115	2014
Crystal structures of the catalytic domain of human soluble guanylate cyclase CK Allerston, F von Delft, O Gileadi PloS one 8 (3), e57644, 2013	108	2013

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