Frank von Delft
Frank von Delft
Principal Investigator: Protein Crystallography, SGC, Oxford University
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Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin
L Pellegrini, DF Burke, F von Delft, B Mulloy, TL Blundell
Nature 407 (6807), 1029-1034, 2000
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
A Douangamath, D Fearon, P Gehrtz, T Krojer, P Lukacik, CD Owen, ...
Nature communications 11 (1), 5047, 2020
CCP4i2: the new graphical user interface to the CCP4 program suite
L Potterton, J Agirre, C Ballard, K Cowtan, E Dodson, PR Evans, ...
Acta Crystallographica Section D: Structural Biology 74 (2), 68-84, 2018
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity
SS Ng, KL Kavanagh, MA McDonough, D Butler, ES Pilka, BMR Lienard, ...
Nature 448 (7149), 87-91, 2007
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases
P Canning, CDO Cooper, T Krojer, JW Murray, ACW Pike, A Chaikuad, ...
Journal of Biological Chemistry 288 (11), 7803-7814, 2013
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming
G Kochan, T Krojer, D Harvey, R Fischer, L Chen, M Vollmar, F von Delft, ...
Proceedings of the National Academy of Sciences 108 (19), 7745-7750, 2011
Structures of ABCB10, a human ATP-binding cassette transporter in apo-and nucleotide-bound states
CA Shintre, ACW Pike, Q Li, JI Kim, AJ Barr, S Goubin, L Shrestha, J Yang, ...
Proceedings of the National Academy of Sciences 110 (24), 9710-9715, 2013
Structure of the CaMKIIδ/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation
P Rellos, ACW Pike, FH Niesen, E Salah, WH Lee, F Von Delft, S Knapp
PLoS biology 8 (7), e1000426, 2010
Rapid covalent-probe discovery by electrophile-fragment screening
E Resnick, A Bradley, J Gan, A Douangamath, T Krojer, R Sethi, ...
Journal of the American Chemical Society 141 (22), 8951-8968, 2019
A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ...
Nature communications 8 (1), 15123, 2017
Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva
A Chaikuad, I Alfano, G Kerr, CE Sanvitale, JH Boergermann, JT Triffitt, ...
Journal of Biological Chemistry 287 (44), 36990-36998, 2012
Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases
D Chen, M Vollmar, MN Rossi, C Phillips, R Kraehenbuehl, D Slade, ...
Journal of Biological Chemistry 286 (15), 13261-13271, 2011
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases
NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ...
Journal of medicinal chemistry 55 (14), 6639-6643, 2012
The crystal structure of human GLRX5: iron–sulfur cluster co-ordination, tetrameric assembly and monomer activity
C Johansson, AK Roos, SJ Montano, R Sengupta, P Filippakopoulos, ...
Biochemical Journal 433 (2), 303-311, 2011
A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP (2), an atypical bromodomain
OB Cox, T Krojer, P Collins, O Monteiro, R Talon, A Bradley, O Fedorov, ...
Chemical science 7 (3), 2322-2330, 2016
Crystal structure of aspartate decarboxylase at 2.2 Å resolution provides evidence for an ester in protein self–processing
A Albert, V Dhanaraj, U Genschel, G Khan, MK Ramjee, R Pulido, ...
Nature structural biology 5 (4), 289-293, 1998
Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A
G Kochan, ES Pilka, F von Delft, U Oppermann, WW Yue
Journal of molecular biology 388 (5), 997-1008, 2009
The structural basis of ZMPSTE24-dependent laminopathies
A Quigley, YY Dong, ACW Pike, L Dong, L Shrestha, G Berridge, ...
Science 339 (6127), 1604-1607, 2013
Ribosomal oxygenases are structurally conserved from prokaryotes to humans
R Chowdhury, R Sekirnik, NC Brissett, T Krojer, C Ho, SS Ng, IJ Clifton, ...
Nature 510 (7505), 422-426, 2014
Crystal structures of the catalytic domain of human soluble guanylate cyclase
CK Allerston, F von Delft, O Gileadi
PloS one 8 (3), e57644, 2013
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