| Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins DJ Schaer, PW Buehler, AI Alayash, JD Belcher, GM Vercellotti Blood, The Journal of the American Society of Hematology 121 (8), 1276-1284, 2013 | 751 | 2013 |
| Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease JD Belcher, C Chen, J Nguyen, L Milbauer, F Abdulla, AI Alayash, A Smith, ... Blood, The Journal of the American Society of Hematology 123 (3), 377-390, 2014 | 663 | 2014 |
| Oxygen therapeutics: can we tame haemoglobin? AI Alayash Nature reviews Drug discovery 3 (2), 152-159, 2004 | 369 | 2004 |
| CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin DJ Schaer, CA Schaer, PW Buehler, RA Boykins, G Schoedon, AI Alayash, ... Blood 107 (1), 373-380, 2006 | 322 | 2006 |
| Redox reactions of hemoglobin and myoglobin: biological and toxicological implications AI Alayash, RP Patel, RE Cashon Antioxidants and Redox Signaling 3 (2), 313-327, 2001 | 285 | 2001 |
| Hemoglobin-based blood substitutes: oxygen carriers, pressor agents, or oxidants? AI Alayash Nature biotechnology 17 (6), 545-549, 1999 | 265 | 1999 |
| Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification PW Buehler, B Abraham, F Vallelian, C Linnemayr, CP Pereira, JF Cipollo, ... Blood, The Journal of the American Society of Hematology 113 (11), 2578-2586, 2009 | 218 | 2009 |
| Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs FS Boretti, PW Buehler, F D’Agnillo, K Kluge, T Glaus, OI Butt, Y Jia, ... The Journal of clinical investigation 119 (8), 2271-2280, 2009 | 215 | 2009 |
| Blood substitutes: why haven’t we been more successful? AI Alayash Trends in biotechnology 32 (4), 177-185, 2014 | 184 | 2014 |
| Structural basis of peroxide-mediated changes in human hemoglobin: a novel oxidative pathway Y Jia, PW Buehler, RA Boykins, RM Venable, AI Alayash Journal of Biological Chemistry 282 (7), 4894-4907, 2007 | 159 | 2007 |
| Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo J Dunne, A Caron, P Menu, AI Alayash, PW Buehler, MT Wilson, ... Biochemical Journal 399 (3), 513-524, 2006 | 129 | 2006 |
| Haptoglobin: old protein with new functions AI Alayash Clinica Chimica Acta 412 (7-8), 493-498, 2011 | 128 | 2011 |
| Toxicities of hemoglobin solutions: in search of in‐vitro and in‐vivo model systems PW Buehler, AI Alayash Transfusion 44 (10), 1516-1530, 2004 | 128 | 2004 |
| Site-specific cross-linking of human and bovine hemoglobins differentially alters oxygen binding and redox side reactions producing rhombic heme and heme degradation E Nagababu, S Ramasamy, JM Rifkind, Y Jia, AI Alayash Biochemistry 41 (23), 7407-7415, 2002 | 124 | 2002 |
| Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145 CE Cooper, DJ Schaer, PW Buehler, MT Wilson, BJ Reeder, G Silkstone, ... Antioxidants & redox signaling 18 (17), 2264-2273, 2013 | 117 | 2013 |
| Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor DJ Schaer, AI Alayash, PW Buehler Antioxidants & redox signaling 9 (7), 991-999, 2007 | 117 | 2007 |
| Acellular hemoglobin-mediated oxidative stress toward endothelium: a role for ferryl iron DW Goldman, RJ Breyer III, D Yeh, BA Brockner-Ryan, AI Alayash American Journal of Physiology-Heart and Circulatory Physiology 275 (3 …, 1998 | 100 | 1998 |
| Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig PW Buehler, F D'Agnillo, V Hoffman, AI Alayash Journal of Pharmacology and Experimental Therapeutics 323 (1), 49-60, 2007 | 99 | 2007 |
| Determination of extinction coefficients of human hemoglobin in various redox states F Meng, AI Alayash Analytical biochemistry 521, 11-19, 2017 | 96 | 2017 |
| Peroxynitrite-mediated heme oxidation and protein modification of native and chemically modified hemoglobins AI Alayash, BAB Ryan, RE Cashon Archives of Biochemistry and Biophysics 349 (1), 65-73, 1998 | 96 | 1998 |
