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Richard I. Morimoto
Richard I. Morimoto
Bill and Gayle Cook Professor of Biology, Dept of Molecular Biosciences, Northwestern
Adresse e-mail validée de northwestern.edu - Page d'accueil
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Adapting proteostasis for disease intervention
WE Balch, RI Morimoto, A Dillin, JW Kelly
science 319 (5865), 916-919, 2008
26752008
Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators
RI Morimoto
Genes & development 12 (24), 3788-3796, 1998
23951998
Geroscience: linking aging to chronic disease
BK Kennedy, SL Berger, A Brunet, J Campisi, AM Cuervo, ES Epel, ...
Cell 159 (4), 709-713, 2014
20282014
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
HM Beere, BB Wolf, K Cain, DD Mosser, A Mahboubi, T Kuwana, P Tailor, ...
Nature cell biology 2 (8), 469-475, 2000
19702000
Cells in stress: transcriptional activation of heat shock genes
RI Morimoto
Science 259 (5100), 1409-1410, 1993
18681993
Heat shock factors: integrators of cell stress, development and lifespan
M Åkerfelt, RI Morimoto, L Sistonen
Nature reviews Molecular cell biology 11 (8), 545-555, 2010
16072010
Role of the heat shock response and molecular chaperones in oncogenesis and cell death
C Jolly, RI Morimoto
Journal of the National Cancer Institute 92 (19), 1564-1572, 2000
14502000
Biological and chemical approaches to diseases of proteostasis deficiency
ET Powers, RI Morimoto, A Dillin, JW Kelly, WE Balch
Annual review of biochemistry 78, 959-991, 2009
14182009
The biology of proteostasis in aging and disease
J Labbadia, RI Morimoto
Annual review of biochemistry 84, 435-464, 2015
13512015
The biology of heat shock proteins and molecular chaperones
RI Morimoto, A Tissières, C Georgopoulos
Cold Spring Harbor Laboratory Press, 1994
1274*1994
Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the …
KD Sarge, SP Murphy, RI Morimoto
Molecular and cellular biology, 1993
11301993
Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.
C Hunt, RI Morimoto
Proceedings of the National Academy of Sciences 82 (19), 6455-6459, 1985
11021985
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
RI Morimoto
Genes & development 22 (11), 1427-1438, 2008
10542008
The chaperone function of hsp70 is required for protection against stress-induced apoptosis
DD Mosser, AW Caron, L Bourget, AB Meriin, MY Sherman, RI Morimoto, ...
Molecular and cellular biology 20 (19), 7146-7159, 2000
9602000
The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
JF Morley, HR Brignull, JJ Weyers, RI Morimoto
Proceedings of the National Academy of Sciences 99 (16), 10417-10422, 2002
9522002
Regulation of Longevity in Caenorhabditis elegans by Heat Shock Factor and Molecular Chaperones
JF Morley, RI Morimoto
Molecular biology of the cell 15 (2), 657-664, 2004
8872004
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
AV Misharin, L Morales-Nebreda, PA Reyfman, CM Cuda, JM Walter, ...
Journal of Experimental Medicine 214 (8), 2387-2404, 2017
8652017
Chaperoning signaling pathways: molecular chaperones as stress-sensingheat shock'proteins
EAA Nollen, RI Morimoto
Journal of cell science 115 (14), 2809-2816, 2002
8602002
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
SD Westerheide, J Anckar, SM Stevens Jr, L Sistonen, RI Morimoto
Science 323 (5917), 1063-1066, 2009
8282009
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development
X Shen, RE Ellis, K Lee, CY Liu, K Yang, A Solomon, H Yoshida, ...
Cell 107 (7), 893-903, 2001
8212001
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