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Michael V Airola
Michael V Airola
Associate Professor, Biochemistry and Cell Biology, Stony Brook University
Adresse e-mail validée de stonybrook.edu - Page d'accueil
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Sphingolipid metabolism and neutral sphingomyelinases
MV Airola, YA Hannun
Sphingolipids: Basic science and drug development, 57-76, 2013
2352013
Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes
AA Shamseddine, MV Airola, YA Hannun
Advances in biological regulation 57, 24-41, 2015
2132015
Structure of concatenated HAMP domains provides a mechanism for signal transduction
MV Airola, KJ Watts, AM Bilwes, BR Crane
Structure 18 (4), 436-448, 2010
1572010
How lipid droplets “TAG” along: Glycerolipid synthetic enzymes and lipid storage
H Wang, MV Airola, K Reue
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2017
1122017
Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation
MV Airola, P Shanbhogue, AA Shamseddine, KE Guja, CE Senkal, ...
Proceedings of the National Academy of Sciences 114 (28), E5549-E5558, 2017
902017
P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest
AA Shamseddine, CJ Clarke, B Carroll, MV Airola, S Mohammed, A Rella, ...
Cell death & disease 6 (10), e1947-e1947, 2015
712015
HAMP domain conformers that propagate opposite signals in bacterial chemoreceptors
MV Airola, N Sukomon, D Samanta, PP Borbat, JH Freed, KJ Watts, ...
PLoS biology 11 (2), e1001479, 2013
682013
Co-expression of ferrochelatase allows for complete heme incorporation into recombinant proteins produced in E. coli
J Sudhamsu, M Kabir, MV Airola, BA Patel, SR Yeh, DL Rousseau, ...
Protein expression and purification 73 (1), 78-82, 2010
632010
Architecture of the soluble receptor Aer2 indicates an in-line mechanism for PAS and HAMP domain signaling
MV Airola, D Huh, N Sukomon, J Widom, R Sircar, PP Borbat, JH Freed, ...
Journal of molecular biology 425 (5), 886-901, 2013
582013
Heme binding to the mammalian circadian clock protein period 2 is nonspecific
MV Airola, J Du, JH Dawson, BR Crane
Biochemistry 49 (20), 4327-4338, 2010
512010
Structural basis for ceramide recognition and hydrolysis by human neutral ceramidase
MV Airola, WJ Allen, MJ Pulkoski-Gross, LM Obeid, RC Rizzo, YA Hannun
Structure 23 (8), 1482-1491, 2015
462015
Crystal structure of a lipin/Pah phosphatidic acid phosphatase
VI Khayyo, RM Hoffmann, H Wang, JA Bell, JE Burke, K Reue, MV Airola
Nature communications 11 (1), 1309, 2020
392020
Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80
X Chen, R Gaglione, T Leong, L Bednor, T de Los Santos, E Luk, M Airola, ...
PLoS genetics 14 (11), e1007832, 2018
342018
Crystal structure of human PLD1 provides insight into activation by PI(4,5)P2 and RhoA
FZ Bowling, CM Salazar, JA Bell, TS Huq, MA Frohman, MV Airola
Nature chemical biology 16 (4), 400-407, 2020
332020
Structure and regulation of human phospholipase D
FZ Bowling, MA Frohman, MV Airola
Advances in biological regulation 79, 100783, 2021
262021
Biallelic loss-of-function variants in PLD1 cause congenital right-sided cardiac valve defects and neonatal cardiomyopathy
N Lahrouchi, AV Postma, CM Salazar, M Daniel, F Tjong, L Piherová, ...
The Journal of Clinical Investigation 131 (5), 2021
182021
Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents
N Pereira de Sa, A Taouil, J Kim, T Clement, RM Hoffmann, JE Burke, ...
Nature communications 12 (1), 5885, 2021
172021
Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae [S]
J Ren, J Snider, MV Airola, A Zhong, NA Rana, LM Obeid, YA Hannun
Journal of Lipid Research 59 (1), 162-170, 2018
162018
Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation
YM Choi, D Ajjaji, KD Fleming, PP Borbat, ML Jenkins, BE Moeller, ...
Nature Communications 14 (1), 3204, 2023
152023
The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme
P Shanbhogue, RM Hoffmann, MV Airola, R Maini, DJ Hamelin, ...
Journal of Biological Chemistry 294 (18), 7488-7502, 2019
152019
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