| Accessing protein conformational ensembles using room-temperature X-ray crystallography JS Fraser, H van den Bedem, AJ Samelson, PT Lang, JM Holton, ... Proceedings of the National Academy of Sciences 108 (39), 16247-16252, 2011 | 492 | 2011 |
| Integrative, dynamic structural biology at atomic resolution—it's about time H Van Den Bedem, JS Fraser Nature methods 12 (4), 307-318, 2015 | 211 | 2015 |
| Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR RB Fenwick, H van den Bedem, JS Fraser, PE Wright Proceedings of the National Academy of Sciences 111 (4), E445-E454, 2014 | 140 | 2014 |
| New paradigm for macromolecular crystallography experiments at SSRL: automated crystal screening and remote data collection SM Soltis, AE Cohen, A Deacon, T Eriksson, A González, S McPhillips, ... Acta Crystallographica Section D: Biological Crystallography 64 (12), 1210-1221, 2008 | 133 | 2008 |
| Automated diffraction image analysis and spot searching for high-throughput crystal screening Z Zhang, NK Sauter, H Van Den Bedem, G Snell, AM Deacon Journal of applied crystallography 39 (1), 112-119, 2006 | 133 | 2006 |
| Automated identification of functional dynamic contact networks from X-ray crystallography H Van Den Bedem, G Bhabha, K Yang, PE Wright, JS Fraser Nature methods 10 (9), 896-902, 2013 | 131 | 2013 |
| Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography DA Keedy, LR Kenner, M Warkentin, RA Woldeyes, JB Hopkins, ... Elife 4, e07574, 2015 | 129 | 2015 |
| Crystal cryocooling distorts conformational heterogeneity in a model Michaelis complex of DHFR DA Keedy, H Van Den Bedem, DA Sivak, GA Petsko, D Ringe, MA Wilson, ... Structure 22 (6), 899-910, 2014 | 105 | 2014 |
| Modeling discrete heterogeneity in X-ray diffraction data by fitting multi-conformers H Van Den Bedem, A Dhanik, JC Latombe, AM Deacon Acta Crystallographica Section D: Biological Crystallography 65 (10), 1107-1117, 2009 | 105 | 2009 |
| Crystal structures of two novel dye‐decolorizing peroxidases reveal a β‐barrel fold with a conserved heme‐binding motif C Zubieta, SS Krishna, M Kapoor, P Kozbial, D McMullan, HL Axelrod, ... Proteins: Structure, Function, and Bioinformatics 69 (2), 223-233, 2007 | 90 | 2007 |
| Identification and structural characterization of heme binding in a novel dye‐decolorizing peroxidase, TyrA C Zubieta, R Joseph, S Sri Krishna, D McMullan, M Kapoor, HL Axelrod, ... Proteins: Structure, Function, and Bioinformatics 69 (2), 234-243, 2007 | 82 | 2007 |
| Structural basis of murein peptide specificity of a γ-D-glutamyl-L-diamino acid endopeptidase Q Xu, S Sudek, D McMullan, MD Miller, B Geierstanger, DH Jones, ... Structure 17 (2), 303-313, 2009 | 78 | 2009 |
| Exposing hidden alternative backbone conformations in X-ray crystallography using qFit DA Keedy, JS Fraser, H van den Bedem PLoS computational biology 11 (10), e1004507, 2015 | 70 | 2015 |
| Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 Å resolution P Kuhn, SA Lesley, II Mathews, JM Canaves, LS Brinen, X Dai, ... Proteins: Structure, Function, and Bioinformatics 49 (1), 142-145, 2002 | 70 | 2002 |
| Real-space protein-model completion: an inverse-kinematics approach H Van Den Bedem, I Lotan, JC Latombe, AM Deacon Acta Crystallographica Section D: Biological Crystallography 61 (1), 2-13, 2005 | 69 | 2005 |
| Structure of the γ-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-γ-D-Glu: insights into substrate recognition by NlpC/P60 cysteine … Q Xu, P Abdubek, T Astakhova, HL Axelrod, C Bakolitsa, X Cai, D Carlton, ... Acta Crystallographica Section F: Structural Biology and Crystallization …, 2010 | 66 | 2010 |
| Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 Å resolution reveals a new fold C Rife, R Schwarzenbacher, D McMullan, P Abdubek, E Ambing, ... Proteins: Structure, Function, and Bioinformatics 61 (2), 449-453, 2005 | 58 | 2005 |
| Efficient algorithms to explore conformation spaces of flexible protein loops P Yao, A Dhanik, N Marz, R Propper, C Kou, G Liu, H Van Den Bedem, ... IEEE/ACM Transactions on Computational Biology and Bioinformatics 5 (4), 534-545, 2008 | 48 | 2008 |
| Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair D Das, D Moiani, HL Axelrod, MD Miller, D McMullan, KK Jin, P Abdubek, ... Journal of molecular biology 397 (3), 647-663, 2010 | 46 | 2010 |
| Conformational variation of proteins at room temperature is not dominated by radiation damage S Russi, A González, LR Kenner, DA Keedy, JS Fraser, H Bedem Journal of synchrotron radiation 24 (1), 73-82, 2017 | 45 | 2017 |
James Solomon FraserProfessor, University of California San FranciscoVerified email at ucsf.edu
