Model-based integrated optimization and evaluation of a multi-step ion exchange chromatography TC Huuk, T Hahn, A Osberghaus, J Hubbuch Separation and Purification Technology 136, 207-222, 2014 | 81 | 2014 |
Good modeling practice for industrial chromatography: mechanistic modeling of ion exchange chromatography of a bispecific antibody F Rischawy, D Saleh, T Hahn, S Oelmeier, J Spitz, S Kluters Computers & Chemical Engineering 130, 106532, 2019 | 63 | 2019 |
Simulating and optimizing preparative protein chromatography with ChromX T Hahn, T Huuk, V Heuveline, J Hubbuch Journal of Chemical Education 92 (9), 1497-1502, 2015 | 59 | 2015 |
Estimation of adsorption isotherm and mass transfer parameters in protein chromatography using artificial neural networks G Wang, T Briskot, T Hahn, P Baumann, J Hubbuch Journal of Chromatography A 1487, 211-217, 2017 | 58 | 2017 |
UV absorption‐based inverse modeling of protein chromatography T Hahn, P Baumann, T Huuk, V Heuveline, J Hubbuch Engineering in Life Sciences 16 (2), 99-106, 2016 | 51 | 2016 |
HiFlow3 a flexible and hardware-aware parallel finite element package V Heuveline Proceedings of the 9th Workshop on Parallel/High-Performance Object-Oriented …, 2010 | 50 | 2010 |
Water on hydrophobic surfaces: Mechanistic modeling of hydrophobic interaction chromatography G Wang, T Hahn, J Hubbuch Journal of Chromatography A 1465, 71-78, 2016 | 41 | 2016 |
Adjoint-based estimation and optimization for column liquid chromatography models T Hahn, A Sommer, A Osberghaus, V Heuveline, J Hubbuch Computers & Chemical Engineering 64, 41-54, 2014 | 41 | 2014 |
Modeling of complex antibody elution behavior under high protein load densities in ion exchange chromatography using an asymmetric activity coefficient TC Huuk, T Hahn, K Doninger, J Griesbach, S Hepbildikler, J Hubbuch Biotechnology journal 12 (3), 1600336, 2017 | 39 | 2017 |
Modeling and simulation of anion-exchange membrane chromatography for purification of Sf9 insect cell-derived virus-like particles CL Effio, T Hahn, J Seiler, SA Oelmeier, I Asen, C Silberer, L Villain, ... Journal of Chromatography A 1429, 142-154, 2016 | 38 | 2016 |
Root cause investigation of deviations in protein chromatography based on mechanistic models and artificial neural networks G Wang, T Briskot, T Hahn, P Baumann, J Hubbuch Journal of Chromatography A 1515, 146-153, 2017 | 37 | 2017 |
Toward in silico CMC: An industrial collaborative approach to model‐based process development D Roush, D Asthagiri, DK Babi, S Benner, C Bilodeau, G Carta, P Ernst, ... Biotechnology and bioengineering 117 (12), 3986-4000, 2020 | 36 | 2020 |
A versatile noninvasive method for adsorber quantification in batch and column chromatography based on the ionic capacity TC Huuk, T Briskot, T Hahn, J Hubbuch Biotechnology progress 32 (3), 666-677, 2016 | 32 | 2016 |
High‐throughput micro‐scale cultivations and chromatography modeling: Powerful tools for integrated process development P Baumann, T Hahn, J Hubbuch Biotechnology and bioengineering 112 (10), 2123-2133, 2015 | 32 | 2015 |
Calibration‐free inverse modeling of ion‐exchange chromatography in industrial antibody purification T Hahn, T Huuk, A Osberghaus, K Doninger, S Nath, S Hepbildikler, ... Engineering in Life Sciences 16 (2), 107-113, 2016 | 31 | 2016 |
Model-based quantification of load shift potentials and optimized charging of electric vehicles T Hahn, M Schönfelder, P Jochem, V Heuveline, W Fichtner | 31 | 2013 |
Protein adsorption on ion exchange adsorbers: A comparison of a stoichiometric and non-stoichiometric modeling approach T Briskot, T Hahn, T Huuk, J Hubbuch Journal of Chromatography A 1653, 462397, 2021 | 29 | 2021 |
Application of spectral deconvolution and inverse mechanistic modelling as a tool for root cause investigation in protein chromatography N Brestrich, T Hahn, J Hubbuch Journal of Chromatography A 1437, 158-167, 2016 | 27 | 2016 |
HiFlow3: A Hardware-Aware Parallel Finite Element Package H Anzt, W Augustin, M Baumann, T Gengenbach, T Hahn, ... Tools for High Performance Computing 2011: Proceedings of the 5th …, 2012 | 26 | 2012 |
Modeling the Gibbs–Donnan effect during ultrafiltration and diafiltration processes using the Poisson–Boltzmann theory in combination with a basic Stern model T Briskot, N Hillebrandt, S Kluters, G Wang, J Studts, T Hahn, T Huuk, ... Journal of Membrane Science 648, 120333, 2022 | 22 | 2022 |