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Julian D. Hegemann
Julian D. Hegemann
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) / HZI
Adresse e-mail validée de helmholtz-hips.de - Page d'accueil
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Lasso peptides: an intriguing class of bacterial natural products
JD Hegemann, M Zimmermann, X Xie, MA Marahiel
Accounts of chemical research 48 (7), 1909-1919, 2015
3452015
Lasso peptides from proteobacteria: genome mining employing heterologous expression and mass spectrometry
JD Hegemann, M Zimmermann, S Zhu, D Klug, MA Marahiel
Peptide Science 100 (5), 527-542, 2013
1312013
Insights into the unique phosphorylation of the lasso peptide paeninodin
S Zhu, JD Hegemann, CD Fage, M Zimmermann, X Xie, U Linne, ...
Journal of Biological Chemistry 291 (26), 13662-13678, 2016
1242016
Caulosegnins I–III: a highly diverse group of lasso peptides derived from a single biosynthetic gene cluster
JD Hegemann, M Zimmermann, X Xie, MA Marahiel
Journal of the American Chemical Society 135 (1), 210-222, 2013
1132013
The astexin-1 lasso peptides: biosynthesis, stability, and structural studies
M Zimmermann, JD Hegemann, X Xie, MA Marahiel
Chemistry & biology 20 (4), 558-569, 2013
972013
Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides
JD Hegemann, M De Simone, M Zimmermann, TA Knappe, X Xie, ...
Journal of Medicinal Chemistry 57 (13), 5829-5834, 2014
882014
Xanthomonins I–III: A New Class of Lasso Peptides with a Seven‐Residue Macrolactam Ring
JD Hegemann, M Zimmermann, S Zhu, H Steuber, K Harms, X Xie, ...
Angewandte Chemie International Edition 53 (8), 2230-2234, 2014
852014
The PqqD homologous domain of the radical SAM enzyme ThnB is required for thioether bond formation during thurincin H maturation
BM Wieckowski, JD Hegemann, A Mielcarek, L Boss, O Burghaus, ...
FEBS letters 589 (15), 1802-1806, 2015
832015
Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials
S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl, JD Hegemann, ...
EMBO reports 24 (1), e56033, 2023
712023
The B1 protein guides the biosynthesis of a lasso peptide
S Zhu, CD Fage, JD Hegemann, A Mielcarek, D Yan, U Linne, ...
Scientific reports 6 (1), 1-12, 2016
672016
Enterobacter bugandensis: a novel enterobacterial species associated with severe clinical infection
NB Pati, SP Doijad, T Schultze, GK Mannala, Y Yao, S Jaiswal, D Ryan, ...
Scientific reports 8 (1), 5392, 2018
642018
Ion mobility–mass spectrometry of lasso peptides: signature of a rotaxane topology
K Jeanne Dit Fouque, C Afonso, S Zirah, JD Hegemann, M Zimmermann, ...
Analytical chemistry 87 (2), 1166-1172, 2015
542015
Characterization of caulonodin lasso peptides revealed unprecedented N-terminal residues and a precursor motif essential for peptide maturation
M Zimmermann, JD Hegemann, X Xie, MA Marahiel
Chemical Science 5 (10), 4032-4043, 2014
532014
Investigation of substrate recognition and biosynthesis in class IV lanthipeptide systems
JD Hegemann, WA Van Der Donk
Journal of the American Chemical Society 140 (17), 5743-5754, 2018
482018
Factors governing the thermal stability of lasso peptides
JD Hegemann
ChemBioChem 21 (1-2), 7-18, 2020
462020
Matters of class: coming of age of class III and IV lanthipeptides
JD Hegemann, RD Süssmuth
RSC Chemical Biology 1 (3), 110-127, 2020
462020
The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II
JD Hegemann, CD Fage, S Zhu, K Harms, FS Di Leva, E Novellino, ...
Molecular BioSystems 12 (4), 1106-1109, 2016
402016
Light‐controlled tyrosine nitration of proteins
T Long, L Liu, Y Tao, W Zhang, J Quan, J Zheng, JD Hegemann, ...
Angewandte Chemie International Edition 60 (24), 13414-13422, 2021
372021
Structural basis for natural product selection and export by bacterial ABC transporters
M Romano, G Fusco, HG Choudhury, S Mehmood, CV Robinson, S Zirah, ...
ACS chemical biology 13 (6), 1598-1609, 2018
372018
Structural basis for natural product selection and export by bacterial ABC transporters
M Romano, G Fusco, HG Choudhury, S Mehmood, CV Robinson, S Zirah, ...
ACS chemical biology 13 (6), 1598-1609, 2018
372018
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