Tomas Ganz
Tomas Ganz
Distinguished Professor of Medicine and Pathology, UCLA
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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
E Nemeth, MS Tuttle, J Powelson, MB Vaughn, A Donovan, DMV Ward, ...
science 306 (5704), 2090-2093, 2004
Defensins: antimicrobial peptides of innate immunity
T Ganz
Nature reviews immunology 3 (9), 710-720, 2003
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
E Nemeth, S Rivera, V Gabayan, C Keller, S Taudorf, BK Pedersen, ...
The Journal of clinical investigation 113 (9), 1271-1276, 2004
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
CH Park, EV Valore, AJ Waring, T Ganz
Journal of biological chemistry 276 (11), 7806-7810, 2001
Endogenous antimicrobial peptides and skin infections in atopic dermatitis
PY Ong, T Ohtake, C Brandt, I Strickland, M Boguniewicz, T Ganz, ...
New England Journal of Medicine 347 (15), 1151-1160, 2002
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
T Ganz
Blood 102 (3), 783-788, 2003
Defensins. Natural peptide antibiotics of human neutrophils.
T Ganz, ME Selsted, D Szklarek, SS Harwig, K Daher, DF Bainton, ...
The Journal of clinical investigation 76 (4), 1427-1435, 1985
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
E Nemeth, EV Valore, M Territo, G Schiller, A Lichtenstein, T Ganz
Blood, The Journal of the American Society of Hematology 101 (7), 2461-2463, 2003
Hepcidin and iron homeostasis
T Ganz, E Nemeth
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823 (9), 1434-1443, 2012
Defensins: antimicrobial and cytotoxic peptides of mammalian cells
RI Lehrer, AK Lichtenstein, T Ganz
Annual review of immunology 11 (1), 105-128, 1993
An antimicrobial activity of cytolytic T cells mediated by granulysin
S Stenger, DA Hanson, R Teitelbaum, P Dewan, KR Niazi, CJ Froelich, ...
Science 282 (5386), 121-125, 1998
Reduced Paneth cell α-defensins in ileal Crohn's disease
J Wehkamp, NH Salzman, E Porter, S Nuding, M Weichenthal, RE Petras, ...
Proceedings of the National Academy of Sciences 102 (50), 18129-18134, 2005
Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis
G Papanikolaou, ME Samuels, EH Ludwig, MLE MacDonald, ...
Nature genetics 36 (1), 77-82, 2004
Identification of erythroferrone as an erythroid regulator of iron metabolism
L Kautz, G Jung, EV Valore, S Rivella, E Nemeth, T Ganz
Nature genetics 46 (7), 678-684, 2014
Hepcidin and iron regulation, 10 years later
T Ganz
Blood, The Journal of the American Society of Hematology 117 (17), 4425-4433, 2011
Systemic iron homeostasis
T Ganz
Physiological reviews 93 (4), 1721-1741, 2013
Antimicrobial peptides in mammalian and insect host defence
RI Lehrer, T Ganz
Current opinion in immunology 11 (1), 23-27, 1999
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
T Tanno, NV Bhanu, PA Oneal, SH Goh, P Staker, YT Lee, JW Moroney, ...
Nature medicine 13 (9), 1096-1101, 2007
Regulation of iron metabolism by hepcidin
E Nemeth, T Ganz
Annu. Rev. Nutr. 26, 323-342, 2006
Human beta-defensin-1: an antimicrobial peptide of urogenital tissues.
EV Valore, CH Park, AJ Quayle, KR Wiles, PB McCray, T Ganz
The Journal of clinical investigation 101 (8), 1633-1642, 1998
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