| Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease MW Beck, JS Derrick, RA Kerr, SB Oh, WJ Cho, SJC Lee, Y Ji, J Han, ... Nature Communications 7 (1), 13115, 2016 | 83 | 2016 |
| A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease MW Beck, SB Oh, RA Kerr, HJ Lee, SH Kim, S Kim, M Jang, BT Ruotolo, ... Chemical Science 6 (3), 1879-1886, 2015 | 75 | 2015 |
| A redox-active, compact molecule for cross-linking amyloidogenic peptides into nontoxic, off-pathway aggregates: in vitro and in vivo efficacy and molecular mechanisms JS Derrick, RA Kerr, Y Nam, SB Oh, HJ Lee, KG Earnest, N Suh, KL Peck, ... Journal of the American Chemical Society 137 (46), 14785-14797, 2015 | 68 | 2015 |
| Sizing up protein–ligand complexes: The rise of structural mass spectrometry approaches in the pharmaceutical sciences JD Eschweiler, R Kerr, J Rabuck-Gibbons, BT Ruotolo Annual Review of Analytical Chemistry 10, 25-44, 2017 | 58 | 2017 |
| Structural dynamics associated with intermediate formation in an archetypal conformational disease MP Nyon, L Segu, LD Cabrita, GR Lévy, J Kirkpatrick, BD Roussel, ... Structure 20 (3), 504-512, 2012 | 35 | 2012 |
| Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter‐Related Pathological Features in Alzheimer's Disease HJ Lee, KJ Korshavn, Y Nam, J Kang, TJ Paul, RA Kerr, IS Youn, M Ozbil, ... Chemistry-A European Journal 23 (11), 2706-2715, 2017 | 32 | 2017 |
| Effects of hydroxyl group variations on a flavonoid backbone toward modulation of metal-free and metal-induced amyloid-β aggregation HJ Lee, RA Kerr, KJ Korshavn, J Lee, J Kang, A Ramamoorthy, ... Inorganic Chemistry Frontiers 3 (3), 381-392, 2016 | 31 | 2016 |
| Importance of the dimethylamino functionality on a multifunctional framework for regulating metals, amyloid-β, and oxidative stress in alzheimer’s disease JS Derrick, RA Kerr, KJ Korshavn, MJ McLane, J Kang, E Nam, ... Inorganic Chemistry 55 (10), 5000-5013, 2016 | 22 | 2016 |
| The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores O Willhoft, R Kerr, D Patel, W Zhang, C Al-Jassar, T Daviter, SH Millson, ... Scientific reports 7 (1), 41626, 2017 | 20 | 2017 |
| The impact of standard accelerated stability conditions on antibody higher order structure as assessed by mass spectrometry RA Kerr, DA Keire, H Ye MAbs 11 (5), 930-941, 2019 | 19 | 2019 |
| Minor structural variations of small molecules tune regulatory activities toward pathological factors in Alzheimer's disease MW Beck, JS Derrick, JM Suh, M Kim, KJ Korshavn, RA Kerr, WJ Cho, ... ChemMedChem 12 (22), 1828-1838, 2017 | 18 | 2017 |
| Complex formed between intramembrane metalloprotease SpoIVFB and its substrate, Pro-σK Y Zhang, S Halder, RA Kerr, D Parrell, B Ruotolo, L Kroos Journal of Biological Chemistry 291 (19), 10347-10362, 2016 | 6 | 2016 |
| Ion mobility & mass spectrometric studies of macromolecules required for organism viability RA Kerr UCL (University College London), 2013 | | 2013 |
Brandon RuotoloProfessor, Department of Chemistry, University of MichiganAdresse e-mail validée de umich.edu
