| Traversing the basement membrane in vivo: a diversity of strategies LC Kelley, LL Lohmer, EJ Hagedorn, DR Sherwood Journal of Cell Biology 204 (3), 291-302, 2014 | 197 | 2014 |
| Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification BL Rothschild, AH Shim, AG Ammer, LC Kelley, KB Irby, JA Head, L Chen, ... Cancer research 66 (16), 8017-8025, 2006 | 175 | 2006 |
| Invasive cell fate requires G1 cell-cycle arrest and histone deacetylase-mediated changes in gene expression DQ Matus, LL Lohmer, LC Kelley, AJ Schindler, AQ Kohrman, ... Developmental cell 35 (2), 162-174, 2015 | 157 | 2015 |
| Adaptive F-actin polymerization and localized ATP production drive basement membrane invasion in the absence of MMPs LC Kelley, Q Chi, R Cáceres, E Hastie, AJ Schindler, Y Jiang, DQ Matus, ... Developmental cell 48 (3), 313-328. e8, 2019 | 121 | 2019 |
| Comprehensive endogenous tagging of basement membrane components reveals dynamic movement within the matrix scaffolding DP Keeley, E Hastie, R Jayadev, LC Kelley, Q Chi, SG Payne, JL Jeger, ... Developmental cell 54 (1), 60-74. e7, 2020 | 99 | 2020 |
| Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence LC Kelley, KE Hayes, AG Ammer, KH Martin, SA Weed PloS one 5 (11), e13847, 2010 | 98 | 2010 |
| Invadopodia and basement membrane invasion in vivo LL Lohmer, LC Kelley, EJ Hagedorn, DR Sherwood Cell adhesion & migration 8 (3), 246-255, 2014 | 89 | 2014 |
| Saracatinib impairs head and neck squamous cell carcinoma invasion by disrupting invadopodia function AG Ammer, LC Kelley, KE Hayes, JV Evans, LA Lopez-Skinner, KH Martin, ... Journal of cancer science & therapy 1 (2), 052, 2009 | 83 | 2009 |
| Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation LC Kelley, AG Ammer, KE Hayes, KH Martin, K Machida, L Jia, BJ Mayer, ... Journal of cell science 123 (22), 3923-3932, 2010 | 76 | 2010 |
| Cell invasion in vivo via rapid exocytosis of a transient lysosome-derived membrane domain KM Naegeli, E Hastie, A Garde, Z Wang, DP Keeley, KL Gordon, AM Pani, ... Developmental cell 43 (4), 403-417. e10, 2017 | 72 | 2017 |
| PI3K activation is required for PMA-directed activation of cSrc by AFAP-110 VG Walker, A Ammer, Z Cao, AC Clump, BH Jiang, LC Kelley, SA Weed, ... American Journal of Physiology-Cell Physiology 293 (1), C119-C132, 2007 | 54 | 2007 |
| ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo EJ Hagedorn, LC Kelley, KM Naegeli, Z Wang, Q Chi, DR Sherwood Journal of Cell Biology 204 (7), 1209-1218, 2014 | 52 | 2014 |
| α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes R Jayadev, Q Chi, DP Keeley, EL Hastie, LC Kelley, DR Sherwood Journal of Cell Biology 218 (9), 3098-3116, 2019 | 51 | 2019 |
| Actin cytoskeletal mediators of motility and invasion amplified and overexpressed in head and neck cancer LC Kelley, S Shahab, SA Weed Clinical & Experimental Metastasis 25, 289-304, 2008 | 50 | 2008 |
| Ableson kinases negatively regulate invadopodia function and invasion in head and neck squamous cell carcinoma by inhibiting an HB-EGF autocrine loop KE Hayes, EL Walk, AG Ammer, LC Kelley, KH Martin, SA Weed Oncogene 32 (40), 4766-4777, 2013 | 49 | 2013 |
| NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6–dependent manner VK Kozyreva, SL McLaughlin, RH Livengood, RA Calkins, LC Kelley, ... Molecular Cancer Research 12 (5), 681-693, 2014 | 43 | 2014 |
| Revisiting the ERK/Src cortactin switch LC Kelley, KE Hayes, A Gatesman Ammer, KH Martin, SA Weed Communicative & integrative biology 4 (2), 205-207, 2011 | 41 | 2011 |
| Cortactin is a substrate of activated Cdc42-associated kinase 1 (ACK1) during ligand-induced epidermal growth factor receptor downregulation LC Kelley, SA Weed Public Library of Science 7 (8), e44363, 2012 | 38 | 2012 |
| Dual targeting of mesenchymal and amoeboid motility hinders metastatic behavior BC Jones, LC Kelley, YV Loskutov, KM Marinak, VK Kozyreva, ... Molecular Cancer Research 15 (6), 670-682, 2017 | 37 | 2017 |
| Forces drive basement membrane invasion in Caenorhabditis elegans R Cáceres, N Bojanala, LC Kelley, J Dreier, J Manzi, F Di Federico, Q Chi, ... Proceedings of the National Academy of Sciences 115 (45), 11537-11542, 2018 | 34 | 2018 |
David R. SherwoodProfessor of Biology, Duke UniversityAdresse e-mail validée de duke.edu
