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Laura Catherine Kelley
Laura Catherine Kelley
Research Scientist
Adresse e-mail validée de duke.edu
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Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification
BL Rothschild, AH Shim, AG Ammer, LC Kelley, KB Irby, JA Head, L Chen, ...
Cancer Research 66 (16), 8017-8025, 2006
1672006
Traversing the basement membrane in vivo: a diversity of strategies
LC Kelley, LL Lohmer, EJ Hagedorn, DR Sherwood
Journal of Cell Biology 204 (3), 291-302, 2014
1642014
Invasive cell fate requires G1 cell-cycle arrest and histone deacetylase-mediated changes in gene expression
DQ Matus, LL Lohmer, LC Kelley, AJ Schindler, AQ Kohrman, ...
Developmental cell 35 (2), 162-174, 2015
1172015
Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence
LC Kelley, KE Hayes, AG Ammer, KH Martin, SA Weed
PloS one 5 (11), e13847, 2010
942010
Saracatinib impairs head and neck squamous cell carcinoma invasion by disrupting invadopodia function
AG Ammer, LC Kelley, KE Hayes, JV Evans, LA Lopez-Skinner, KH Martin, ...
Journal of cancer science & therapy 1 (2), 052, 2009
762009
Invadopodia and basement membrane invasion in vivo
LL Lohmer, LC Kelley, EJ Hagedorn, DR Sherwood
Cell adhesion & migration 8 (3), 246-255, 2014
732014
Adaptive F-actin polymerization and localized ATP production drive basement membrane invasion in the absence of MMPs
LC Kelley, Q Chi, R Cáceres, E Hastie, AJ Schindler, Y Jiang, DQ Matus, ...
Developmental cell 48 (3), 313-328. e8, 2019
682019
Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation
LC Kelley, AG Ammer, KE Hayes, KH Martin, K Machida, L Jia, BJ Mayer, ...
Journal of cell science 123 (22), 3923-3932, 2010
622010
Cell invasion in vivo via rapid exocytosis of a transient lysosome-derived membrane domain
KM Naegeli, E Hastie, A Garde, Z Wang, DP Keeley, KL Gordon, AM Pani, ...
Developmental cell 43 (4), 403-417. e10, 2017
512017
PI3K activation is required for PMA-directed activation of cSrc by AFAP-110
VG Walker, A Ammer, Z Cao, AC Clump, BH Jiang, LC Kelley, SA Weed, ...
American Journal of Physiology-Cell Physiology 293 (1), C119-C132, 2007
512007
ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo
EJ Hagedorn, LC Kelley, KM Naegeli, Z Wang, Q Chi, DR Sherwood
Journal of Cell Biology 204 (7), 1209-1218, 2014
472014
Ableson kinases negatively regulate invadopodia function and invasion in head and neck squamous cell carcinoma by inhibiting an HB-EGF autocrine loop
KE Hayes, EL Walk, AG Ammer, LC Kelley, KH Martin, SA Weed
Oncogene 32 (40), 4766-4777, 2013
472013
Actin cytoskeletal mediators of motility and invasion amplified and overexpressed in head and neck cancer
LC Kelley, S Shahab, SA Weed
Clinical & experimental metastasis 25 (4), 289-304, 2008
462008
Comprehensive endogenous tagging of basement membrane components reveals dynamic movement within the matrix scaffolding
DP Keeley, E Hastie, R Jayadev, LC Kelley, Q Chi, SG Payne, JL Jeger, ...
Developmental cell 54 (1), 60-74. e7, 2020
392020
NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6–dependent manner
VK Kozyreva, SL McLaughlin, RH Livengood, RA Calkins, LC Kelley, ...
Molecular Cancer Research 12 (5), 681-693, 2014
382014
Revisiting the ERK/Src cortactin switch
LC Kelley, KE Hayes, A Gatesman Ammer, KH Martin, SA Weed
Communicative & integrative biology 4 (2), 205-207, 2011
372011
Cortactin is a substrate of activated Cdc42-associated kinase 1 (ACK1) during ligand-induced epidermal growth factor receptor downregulation
LC Kelley, SA Weed
Public Library of Science 7 (8), e44363, 2012
292012
Dual targeting of mesenchymal and amoeboid motility hinders metastatic behavior
BC Jones, LC Kelley, YV Loskutov, KM Marinak, VK Kozyreva, ...
Molecular Cancer Research 15 (6), 670-682, 2017
272017
α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes
R Jayadev, Q Chi, DP Keeley, EL Hastie, LC Kelley, DR Sherwood
Journal of Cell Biology 218 (9), 3098-3116, 2019
242019
Forces drive basement membrane invasion in Caenorhabditis elegans
R Cáceres, N Bojanala, LC Kelley, J Dreier, J Manzi, F Di Federico, Q Chi, ...
Proceedings of the National Academy of Sciences 115 (45), 11537-11542, 2018
202018
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