| The role of kinetic context in apparent biased agonism at GPCRs C Klein Herenbrink, DA Sykes, P Donthamsetti, M Canals, T Coudrat, ... Nature communications 7 (1), 10842, 2016 | 320 | 2016 |
| Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief DD Jensen, TM Lieu, ML Halls, NA Veldhuis, WL Imlach, QN Mai, ... Science Translational Medicine 9 (392), eaal3447, 2017 | 192 | 2017 |
| Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission RE Yarwood, WL Imlach, TM Lieu, NA Veldhuis, DD Jensen, ... Proceedings of the National Academy of Sciences 114 (46), 12309-12314, 2017 | 154 | 2017 |
| Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome NN Jimenez-Vargas, LA Pattison, P Zhao, TM Lieu, R Latorre, DD Jensen, ... Proceedings of the National Academy of Sciences 115 (31), E7438-E7447, 2018 | 150 | 2018 |
| A structure–activity analysis of biased agonism at the dopamine D2 receptor J Shonberg, CK Herenbrink, L Lopez, A Christopoulos, PJ Scammells, ... Journal of medicinal chemistry 56 (22), 9199-9221, 2013 | 103 | 2013 |
| Structure–Activity Relationships of Privileged Structures Lead to the Discovery of Novel Biased Ligands at the Dopamine D2 Receptor M Szabo, C Klein Herenbrink, A Christopoulos, JR Lane, B Capuano Journal of medicinal chemistry 57 (11), 4924-4939, 2014 | 88 | 2014 |
| Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand SN Mistry, J Shonberg, CJ Draper-Joyce, C Klein Herenbrink, M Michino, ... Journal of medicinal chemistry 58 (17), 6819-6843, 2015 | 54 | 2015 |
| A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A2A receptor JR Lane, CK Herenbrink, GJP Van Westen, JA Spoorendonk, C Hoffmann, ... Molecular pharmacology 81 (3), 475-487, 2012 | 53 | 2012 |
| The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor CJ Draper-Joyce, M Michino, RK Verma, CK Herenbrink, J Shonberg, ... Biochemical pharmacology 148, 315-328, 2018 | 28 | 2018 |
| Molecular determinants of the intrinsic efficacy of the antipsychotic aripiprazole C Klein Herenbrink, R Verma, HD Lim, A Kopinathan, A Keen, J Shonberg, ... ACS chemical biology 14 (8), 1780-1792, 2019 | 24 | 2019 |
| The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions CJ Draper-Joyce, RK Verma, M Michino, J Shonberg, A Kopinathan, ... Scientific Reports 8 (1), 1208, 2018 | 16 | 2018 |
| Proof of Concept Study for Designed Multiple Ligands Targeting the Dopamine D2, Serotonin 5-HT2A, and Muscarinic M1 Acetylcholine Receptors M Szabo, HD Lim, C Klein Herenbrink, A Christopoulos, JR Lane, ... Journal of Medicinal Chemistry 58 (3), 1550-1555, 2015 | 14 | 2015 |
| Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors C Klein Herenbrink, JF Støier, WD Reith, A Dagra, MAC Gregorek, ... Communications Biology 5 (1), 578, 2022 | 13 | 2022 |
| Novel fluorescent ligands enable single-molecule localization microscopy of the dopamine transporter DA Guthrie, C Klein Herenbrink, MD Lycas, T Ku, A Bonifazi, BT DeVree, ... ACS chemical neuroscience 11 (20), 3288-3300, 2020 | 11 | 2020 |
| The role of kinetic context in apparent biased agonism at GPCRs. Nat Commun 7: 10842 C Klein Herenbrink, DA Sykes, P Donthamsetti, M Canals, T Coudrat, ... | 8 | 2016 |
| Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief. Sci Transl Med 9: eaal3447 DD Jensen, T Lieu, ML Halls, NA Veldhuis, WL Imlach, QN Mai, DP Poole, ... | 5 | 2017 |
| Membrane curvature association of amphipathic helix 8 drives constitutive GPCR endocytosis R Herlo, JH Schmidt, J Rombach, AH Larsen, M Stoklund, M Perslev, ... bioRxiv, 2024.03. 27.587027, 2024 | | 2024 |
| Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief CJH Porter, TM Lieu, DD Jensen, TM Lieu, ML Halls, NA Veldhuis, ... Science Translational Medicine 9 (392), 2017 | | 2017 |
| The role of kinetic context in apparent biased agonism at GPCRs JA Javitch, C Klein Herenbrink, DA Sykes, P Donthamsetti, M Canals, ... Nature Communications 7, 0 | | |
| Understanding biased agonism at the dopamine D₂ receptor C Klein Herenbrink Monash University, 0 | | |
Robert LaneAssociate Professor in Molecular Pharmacology, University of Nottingham在 nottingham.ac.uk 的电子邮件经过验证
