| Reversal of tumoral immune resistance by inhibition of tryptophan 2, 3-dioxygenase L Pilotte, P Larrieu, V Stroobant, D Colau, E Dolušić, R Frédérick, ... Proceedings of the National Academy of Sciences 109 (7), 2497-2502, 2012 | 633 | 2012 |
| Lactate dehydrogenase B controls lysosome activity and autophagy in cancer L Brisson, P Bański, M Sboarina, C Dethier, P Danhier, MJ Fontenille, ... Cancer cell 30 (3), 418-431, 2016 | 221 | 2016 |
| Tryptophan 2, 3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl) ethenyl) indoles as potential anticancer immunomodulators E Dolušić, P Larrieu, L Moineaux, V Stroobant, L Pilotte, D Colau, ... Journal of medicinal chemistry 54 (15), 5320-5334, 2011 | 220 | 2011 |
| Coumarin and isocoumarin as serine protease inhibitors L Pochet, R Frédérick, B Masereel Current pharmaceutical design 10 (30), 3781-3796, 2004 | 130 | 2004 |
| Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4, 6-di (4-morpholinyl)-1, 3, 5 … GW Rewcastle, SA Gamage, JU Flanagan, R Frederick, WA Denny, ... Journal of medicinal chemistry 54 (20), 7105-7126, 2011 | 122 | 2011 |
| Synthesis and evaluation of β-carboline derivatives as potential monoamine oxidase inhibitors J Reniers, S Robert, R Frederick, B Masereel, S Vincent, J Wouters Bioorganic & medicinal chemistry 19 (1), 134-144, 2011 | 112 | 2011 |
| Novel trisubstituted harmine derivatives with original in vitro anticancer activity R Frédérick, C Bruyère, C Vancraeynest, J Reniers, C Meinguet, L Pochet, ... Journal of medicinal chemistry 55 (14), 6489-6501, 2012 | 101 | 2012 |
| Discovery and preliminary SARs of keto-indoles as novel indoleamine 2, 3-dioxygenase (IDO) inhibitors E Dolušić, P Larrieu, S Blanc, F Sapunaric, J Pouyez, L Moineaux, ... European journal of medicinal chemistry 46 (7), 3058-3065, 2011 | 99* | 2011 |
| 3, 6-Disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa R Frédérick, S Robert, C Charlier, J de Ruyck, J Wouters, B Pirotte, ... Journal of medicinal chemistry 48 (24), 7592-7603, 2005 | 91 | 2005 |
| New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides T Rogez-Florent, S Meignan, C Foulon, P Six, A Gros, C Bal-Mahieu, ... Bioorganic & medicinal chemistry 21 (6), 1451-1464, 2013 | 76 | 2013 |
| Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110α inhibitors JD Kendall, GW Rewcastle, R Frederick, C Mawson, WA Denny, ... Bioorganic & medicinal chemistry 15 (24), 7677-7687, 2007 | 75 | 2007 |
| Indoleamine 2, 3-dioxygenase inhibitors: a patent review (2008–2012) E Dolušić, R Frédérick Expert opinion on therapeutic patents 23 (10), 1367-1381, 2013 | 72 | 2013 |
| α-Ketothioamide derivatives: a promising tool to interrogate phosphoglycerate dehydrogenase (PHGDH) S Ravez, C Corbet, Q Spillier, A Dutu, AD Robin, E Mullarky, LC Cantley, ... Journal of medicinal chemistry 60 (4), 1591-1597, 2017 | 67 | 2017 |
| Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation Q Spillier, D Vertommen, S Ravez, R Marteau, Q Thémans, C Corbet, ... Scientific reports 9 (1), 4737, 2019 | 59 | 2019 |
| Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors C Bouckaert, S Serra, G Rondelet, E Dolušić, J Wouters, JM Dogné, ... European Journal of Medicinal Chemistry 110, 181-194, 2016 | 54 | 2016 |
| Challenges and Opportunities in the Development of Serine Synthetic Pathway Inhibitors for Cancer Therapy: Miniperspective S Ravez, Q Spillier, R Marteau, O Feron, R Frédérick Journal of medicinal chemistry 60 (4), 1227-1237, 2017 | 50 | 2017 |
| Modulators of the coagulation cascade: focus and recent advances in inhibitors of tissue factor, factor VIIa and their complex R Frédérick, L Pochet, C Charlier, B Masereel Current medicinal chemistry 12 (4), 397-417, 2005 | 49 | 2005 |
| Computational tools for in silico fragment-based drug design J Mortier, C Rakers, R Frederick, G Wolber Current topics in medicinal chemistry 12 (17), 1935-1943, 2012 | 48 | 2012 |
| Arginase structure and inhibition: catalytic site plasticity reveals new modulation possibilities J Mortier, JRC Prévost, D Sydow, S Teuchert, C Omieczynski, ... Scientific Reports 7 (1), 13616, 2017 | 46 | 2017 |
| Thiosemicarbazide, a fragment with promising indolamine-2, 3-dioxygenase (IDO) inhibition properties S Serra, L Moineaux, C Vancraeynest, B Masereel, J Wouters, L Pochet, ... European Journal of Medicinal Chemistry 82, 96-105, 2014 | 46 | 2014 |
Johan WoutersDept Chemistry, UNamurAdresse e-mail validée de unamur.be
