| Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions MW Powner, B Gerland, JD Sutherland Nature 459 (7244), 239-242, 2009 | 1456 | 2009 |
| Chemoselective multicomponent one-pot assembly of purine precursors in water MW Powner, JD Sutherland, JW Szostak Journal of the American Chemical Society 132 (46), 16677-16688, 2010 | 196 | 2010 |
| Peptide ligation by chemoselective aminonitrile coupling in water P Canavelli, S Islam, MW Powner Nature 571 (7766), 546-549, 2019 | 145 | 2019 |
| Prebiotic chemistry: a new modus operandi MW Powner, JD Sutherland Philosophical Transactions of the Royal Society B: Biological Sciences 366 …, 2011 | 139 | 2011 |
| Prebiotic systems chemistry: Complexity overcoming clutter S Islam, MW Powner Chem 2 (4), 470-501, 2017 | 135 | 2017 |
| Functional RNAs exhibit tolerance for non-heritable 2′–5′ versus 3′–5′ backbone heterogeneity AE Engelhart, MW Powner, JW Szostak Nature chemistry 5 (5), 390-394, 2013 | 127 | 2013 |
| Prebiotic synthesis of cysteine peptides that catalyze peptide ligation in neutral water CS Foden, S Islam, C Fernández-García, L Maugeri, TD Sheppard, ... Science 370 (6518), 865-869, 2020 | 118 | 2020 |
| Prebiotically plausible oligoribonucleotide ligation facilitated by chemoselective acetylation FR Bowler, CKW Chan, CD Duffy, B Gerland, S Islam, MW Powner, ... Nature Chemistry 5 (5), 383-389, 2013 | 117 | 2013 |
| Prebiotic selection and assembly of proteinogenic amino acids and natural nucleotides from complex mixtures S Islam, DK Bučar, MW Powner Nature Chemistry 9 (6), 584-589, 2017 | 113 | 2017 |
| Direct assembly of nucleoside precursors from two-and three-carbon units C Anastasi, MA Crowe, MW Powner, JD Sutherland Angewandte Chemie-International Edition 45 (37), 6176-6179, 2006 | 109 | 2006 |
| Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides S Stairs, A Nikmal, DK Bučar, SL Zheng, JW Szostak, MW Powner Nature Communications 8 (1), 15270, 2017 | 106 | 2017 |
| Prebiotic synthesis of phosphoenol pyruvate by α-phosphorylation-controlled triose glycolysis AJ Coggins, MW Powner Nature Chemistry 9 (4), 310-317, 2017 | 104 | 2017 |
| RNA: prebiotic product, or biotic invention? C Anastasi, FF Buchet, MA Crowe, AL Parkes, MW Powner, JM Smith, ... Chemistry & biodiversity 4 (4), 721-739, 2007 | 97 | 2007 |
| Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules M Morasch, J Liu, CF Dirscherl, A Ianeselli, A Kühnlein, K Le Vay, ... Nature Chemistry 11 (9), 779-788, 2019 | 85 | 2019 |
| Multicomponent assembly of proposed DNA precursors in water MW Powner, SL Zheng, JW Szostak Journal of the American Chemical Society 134 (33), 13889-13895, 2012 | 83 | 2012 |
| A chemist’s perspective on the role of phosphorus at the origins of life C Fernández-García, AJ Coggins, MW Powner Life 7 (3), 31, 2017 | 72 | 2017 |
| Phosphate‐Mediated Interconversion of Ribo‐ and Arabino‐Configured Prebiotic Nucleotide Intermediates MW Powner, JD Sutherland Angewandte Chemie International Edition 27 (49), 4641-4643, 2010 | 70 | 2010 |
| The origins of nucleotides MW Powner, JD Sutherland, JW Szostak Synlett 22 (14), 1956-1964, 2011 | 67 | 2011 |
| On the prebiotic synthesis of ribonucleotides: photoanomerisation of cytosine nucleosides and nucleotides revisited MW Powner, C Anastasi, MA Crowe, AL Parkes, J Raftery, JD Sutherland ChemBioChem 8 (10), 1170-1179, 2007 | 57 | 2007 |
| A stereoelectronic effect in prebiotic nucleotide synthesis A Choudhary, KJ Kamer, MW Powner, JD Sutherland, RT Raines ACS chemical biology 5 (7), 655-657, 2010 | 56 | 2010 |
Jack W. SzostakMassachusetts General Hospital, Harvard, HHMIAdresse e-mail validée de molbio.mgh.harvard.edu
