Patrick M Collins
Patrick M Collins
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A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ...
Nature communications 8 (1), 15123, 2017
Galectin‐3‐binding glycomimetics that strongly reduce bleomycin‐induced lung fibrosis and modulate intracellular glycan recognition
T Delaine, P Collins, A MacKinnon, G Sharma, J Stegmayr, VK Rajput, ...
ChemBioChem 17 (18), 1759-1770, 2016
A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP (2), an atypical bromodomain
OB Cox, T Krojer, P Collins, O Monteiro, R Talon, A Bradley, O Fedorov, ...
Chemical science 7 (3), 2322-2330, 2016
Galectin-3 inhibitors: a patent review (2008–present)
H Blanchard, X Yu, PM Collins, K Bum-Erdene
Expert opinion on therapeutic patents 24 (10), 1053-1065, 2014
Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model
KA Stannard, PM Collins, K Ito, EM Sullivan, SA Scott, E Gabutero, ...
Cancer letters 299 (2), 95-110, 2010
Gentle, fast and effective crystal soaking by acoustic dispensing
PM Collins, JT Ng, R Talon, K Nekrosiute, T Krojer, A Douangamath, ...
Acta Crystallographica Section D: Structural Biology 73 (3), 246-255, 2017
The XChemExplorer graphical workflow tool for routine or large-scale protein–ligand structure determination
T Krojer, R Talon, N Pearce, P Collins, A Douangamath, J Brandao-Neto, ...
Acta Crystallographica Section D: Structural Biology 73 (3), 267-278, 2017
Galectin-3 interactions with glycosphingolipids
PM Collins, K Bum-Erdene, X Yu, H Blanchard
Journal of molecular biology 426 (7), 1439-1451, 2014
Slow diffusion of lactose out of galectin-3 crystals monitored by X-ray crystallography: possible implications for ligand-exchange protocols
PM Collins, KIPJ Hidari, H Blanchard
Acta Crystallographica Section D: Biological Crystallography 63 (3), 415-419, 2007
A selective galactose–coumarin-derived galectin-3 inhibitor demonstrates involvement of galectin-3-glycan interactions in a pulmonary fibrosis model
VK Rajput, A MacKinnon, S Mandal, P Collins, H Blanchard, H Leffler, ...
Journal of medicinal chemistry 59 (17), 8141-8147, 2016
Taloside Inhibitors of Galectin‐1 and Galectin‐3
PM Collins, CT Öberg, H Leffler, UJ Nilsson, H Blanchard
Chemical biology & drug design 79 (3), 339-346, 2012
Synthesis and Demonstration of the Biological Relevance of sp3‐rich Scaffolds Distantly Related to Natural Product Frameworks
DJ Foley, PGE Craven, PM Collins, RG Doveston, A Aimon, R Talon, ...
Chemistry–A European Journal 23 (60), 15227-15232, 2017
Characterization of three druggable hot-spots in the Aurora-A/TPX2 interaction using biochemical, biophysical, and fragment-based approaches
PJ McIntyre, PM Collins, L Vrzal, K Birchall, LH Arnold, C Mpamhanga, ...
ACS chemical biology 12 (11), 2906-2914, 2017
Achieving a good crystal system for crystallographic X-ray fragment screening
PM Collins, A Douangamath, R Talon, A Dias, J Brandão-Neto, T Krojer, ...
Methods in enzymology 610, 251-264, 2018
Investigation into the feasibility of thioditaloside as a novel scaffold for galectin‐3‐specific inhibitors
K Bum‐Erdene, IA Gagarinov, PM Collins, M Winger, AG Pearson, ...
ChemBioChem 14 (11), 1331-1342, 2013
Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping
SE Thomas, P Collins, RH James, V Mendes, S Charoensutthivarakul, ...
Philosophical Transactions of the Royal Society A 377 (2147), 20180422, 2019
Small molecule antagonists of the interaction between the histone deacetylase 6 zinc-finger domain and ubiquitin
RJ Harding, R Ferreira de Freitas, P Collins, I Franzoni, M Ravichandran, ...
Journal of Medicinal Chemistry 60 (21), 9090-9096, 2017
Achieving efficient fragment screening at XChem facility at diamond light source
A Douangamath, A Powell, D Fearon, PM Collins, R Talon, T Krojer, ...
JoVE (Journal of Visualized Experiments), e62414, 2021
Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19
MA Redhead, CD Owen, L Brewitz, AH Collette, P Lukacik, ...
Scientific reports 11 (1), 13208, 2021
Towards understanding the functional role of the glycosyltransferases involved in the biosynthesis of Moraxella catarrhalis lipooligosaccharide
IR Peak, ID Grice, I Faglin, Z Klipic, PM Collins, L van Schendel, ...
The FEBS journal 274 (8), 2024-2037, 2007
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