| A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ... Nature communications 8 (1), 15123, 2017 | 199 | 2017 |
| Galectin‐3‐binding glycomimetics that strongly reduce bleomycin‐induced lung fibrosis and modulate intracellular glycan recognition T Delaine, P Collins, A MacKinnon, G Sharma, J Stegmayr, VK Rajput, ... ChemBioChem 17 (18), 1759-1770, 2016 | 146 | 2016 |
| A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP (2), an atypical bromodomain OB Cox, T Krojer, P Collins, O Monteiro, R Talon, A Bradley, O Fedorov, ... Chemical science 7 (3), 2322-2330, 2016 | 136 | 2016 |
| Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model KA Stannard, PM Collins, K Ito, EM Sullivan, SA Scott, E Gabutero, ... Cancer letters 299 (2), 95-110, 2010 | 109 | 2010 |
| Galectin-3 inhibitors: a patent review (2008–present) H Blanchard, X Yu, PM Collins, K Bum-Erdene Expert opinion on therapeutic patents 24 (10), 1053-1065, 2014 | 102 | 2014 |
| Gentle, fast and effective crystal soaking by acoustic dispensing PM Collins, JT Ng, R Talon, K Nekrosiute, T Krojer, A Douangamath, ... Acta Crystallographica Section D: Structural Biology 73 (3), 246-255, 2017 | 88 | 2017 |
| The XChemExplorer graphical workflow tool for routine or large-scale protein–ligand structure determination T Krojer, R Talon, N Pearce, P Collins, A Douangamath, J Brandao-Neto, ... Acta Crystallographica Section D: Structural Biology 73 (3), 267-278, 2017 | 82 | 2017 |
| Galectin-3 interactions with glycosphingolipids PM Collins, K Bum-Erdene, X Yu, H Blanchard Journal of molecular biology 426 (7), 1439-1451, 2014 | 75 | 2014 |
| Slow diffusion of lactose out of galectin-3 crystals monitored by X-ray crystallography: possible implications for ligand-exchange protocols PM Collins, KIPJ Hidari, H Blanchard Acta Crystallographica Section D: Biological Crystallography 63 (3), 415-419, 2007 | 72 | 2007 |
| Taloside Inhibitors of Galectin‐1 and Galectin‐3 PM Collins, CT Öberg, H Leffler, UJ Nilsson, H Blanchard Chemical biology & drug design 79 (3), 339-346, 2012 | 70 | 2012 |
| A selective galactose–coumarin-derived galectin-3 inhibitor demonstrates involvement of galectin-3-glycan interactions in a pulmonary fibrosis model VK Rajput, A MacKinnon, S Mandal, P Collins, H Blanchard, H Leffler, ... Journal of medicinal chemistry 59 (17), 8141-8147, 2016 | 64 | 2016 |
| Synthesis and Demonstration of the Biological Relevance of sp3‐rich Scaffolds Distantly Related to Natural Product Frameworks DJ Foley, PGE Craven, PM Collins, RG Doveston, A Aimon, R Talon, ... Chemistry–A European Journal 23 (60), 15227-15232, 2017 | 57 | 2017 |
| Characterization of three druggable hot-spots in the aurora-A/TPX2 interaction using biochemical, biophysical, and fragment-based approaches PJ McIntyre, PM Collins, L Vrzal, K Birchall, LH Arnold, C Mpamhanga, ... ACS chemical biology 12 (11), 2906-2914, 2017 | 43 | 2017 |
| Investigation into the feasibility of thioditaloside as a novel scaffold for galectin‐3‐specific inhibitors K Bum‐Erdene, IA Gagarinov, PM Collins, M Winger, AG Pearson, ... ChemBioChem 14 (11), 1331-1342, 2013 | 42 | 2013 |
| Achieving a good crystal system for crystallographic X-ray fragment screening PM Collins, A Douangamath, R Talon, A Dias, J Brandão-Neto, T Krojer, ... Methods in enzymology 610, 251-264, 2018 | 40 | 2018 |
| Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping SE Thomas, P Collins, RH James, V Mendes, S Charoensutthivarakul, ... Philosophical Transactions of the Royal Society A 377 (2147), 20180422, 2019 | 36 | 2019 |
| Small molecule antagonists of the interaction between the histone deacetylase 6 zinc-finger domain and ubiquitin RJ Harding, R Ferreira de Freitas, P Collins, I Franzoni, M Ravichandran, ... Journal of Medicinal Chemistry 60 (21), 9090-9096, 2017 | 32 | 2017 |
| Towards understanding the functional role of the glycosyltransferases involved in the biosynthesis of Moraxella catarrhalis lipooligosaccharide IR Peak, ID Grice, I Faglin, Z Klipic, PM Collins, L van Schendel, ... The FEBS journal 274 (8), 2024-2037, 2007 | 30 | 2007 |
| Construction of a Shape‐Diverse Fragment Set: Design, Synthesis and Screen against Aurora‐A Kinase R Zhang, PJ McIntyre, PM Collins, DJ Foley, C Arter, F von Delft, R Bayliss, ... Chemistry–A European Journal 25 (27), 6831-6839, 2019 | 28 | 2019 |
| Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases D Zhang, MS Markoulides, D Stepanovs, AM Rydzik, A El-Hussein, C Bon, ... Bioorganic & Medicinal Chemistry 26 (11), 2928-2936, 2018 | 23 | 2018 |
Frank von DelftPrincipal Investigator: Protein Crystallography, SGC, Oxford UniversityAdresse e-mail validée de sgc.ox.ac.uk
