Antibiotics induce redox-related physiological alterations as part of their lethality DJ Dwyer, PA Belenky, JH Yang, IC MacDonald, JD Martell, N Takahashi, ... Proceedings of the National Academy of Sciences 111 (20), E2100-E2109, 2014 | 862 | 2014 |
A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress CTY Chan, M Dyavaiah, MS DeMott, K Taghizadeh, PC Dedon, TJ Begley PLoS Genetics 6 (12), e1001247, 2010 | 478 | 2010 |
Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins CTY Chan, YLJ Pang, W Deng, IR Babu, M Dyavaiah, TJ Begley, ... Nature communications 3 (1), 937, 2012 | 448 | 2012 |
'Deadman'and'Passcode'microbial kill switches for bacterial containment CTY Chan, JW Lee, DE Cameron, CJ Bashor, JJ Collins Nature chemical biology 12 (2), 82-86, 2016 | 383 | 2016 |
Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry D Su, CTY Chan, C Gu, KS Lim, YH Chionh, ME McBee, BS Russell, ... Nature protocols 9 (4), 828-841, 2014 | 264 | 2014 |
Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival D Fu, JAN Brophy, CTY Chan, KA Atmore, U Begley, RS Paules, ... Molecular and cellular biology 30 (10), 2449-2459, 2010 | 220 | 2010 |
Next-generation biocontainment systems for engineered organisms JW Lee, CTY Chan, S Slomovic, JJ Collins Nature chemical biology, 1, 2018 | 192 | 2018 |
Site-Specific Insertion of 3-Aminotyrosine into Subunit α2 of E. coli Ribonucleotide Reductase: Direct Evidence for Involvement of Y730 and Y731 in Radical … MR Seyedsayamdost, J Xie, CTY Chan, PG Schultz, JA Stubbe Journal of the American Chemical Society 129 (48), 15060-15071, 2007 | 157 | 2007 |
Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications A Patil, C Chan, M Dyavaiah, J Rooney, P Dedon, T Begley RNA biology 9 (7), 2012 | 124 | 2012 |
A human tRNA methyltransferase 9‐like protein prevents tumour growth by regulating LIN9 and HIF1‐α U Begley, MS Sosa, A Avivar‐Valderas, A Patil, L Endres, Y Estrada, ... EMBO molecular medicine 5 (3), 366-383, 2013 | 120 | 2013 |
Highly predictive reprogramming of tRNA modifications is linked to selective expression of codon-biased genes CTY Chan, W Deng, F Li, MS DeMott, IR Babu, TJ Begley, PC Dedon Chemical research in toxicology 28 (5), 978-988, 2015 | 89 | 2015 |
Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response A Patil, M Dyavaiah, F Joseph, JP Rooney, CTY Chan, PC Dedon, ... Cell cycle 11 (19), 3656-3665, 2012 | 89 | 2012 |
PELDOR spectroscopy with DOPA-β2 and NH2Y-α2s: distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase MR Seyedsayamdost, CTY Chan, V Mugnaini, JA Stubbe, M Bennati Journal of the American Chemical Society 129 (51), 15748-15749, 2007 | 77 | 2007 |
Identification of N6,N6-Dimethyladenosine in Transfer RNA from Mycobacterium bovis Bacille Calmette-Guérin CTY Chan, YH Chionh, CH Ho, KS Lim, IR Babu, E Ang, L Wenwei, ... Molecules 16 (6), 5168-5181, 2011 | 29 | 2011 |
Engineering repressors with coevolutionary cues facilitates toggle switches with a master reset RP Dimas, XL Jiang, J Alberto de la Paz, F Morcos, CTY Chan Nucleic acids research 47 (10), 5449-5463, 2019 | 28 | 2019 |
Engineering DNA recognition and allosteric response properties of TetR family proteins by using a module-swapping strategy RP Dimas, BR Jordan, XL Jiang, C Martini, JS Glavy, DP Patterson, ... Nucleic acids research 47 (16), 8913-8925, 2019 | 22 | 2019 |
Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs D Mandal, C Köhrer, D Su, IR Babu, CTY Chan, Y Liu, D Söll, P Blum, ... RNA 20 (2), 177-188, 2014 | 22 | 2014 |
Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions XL Jiang, RP Dimas, CTY Chan, F Morcos Nature communications 12 (1), 5592, 2021 | 19 | 2021 |
The role of gut microbial β-glucuronidase in drug disposition and development S Gao, R Sun, R Singh, SY So, CTY Chan, T Savidge, M Hu Drug discovery today 27 (10), 103316, 2022 | 8 | 2022 |
A domain swapping strategy to create modular transcriptional regulators for novel topology in genetic network CTY Chan, V Kennedy, S Kinshuk Biotechnology Advances, 108345, 2024 | | 2024 |