Accessing unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis S Emond, M Petek, EJ Kay, B Heames, SRA Devenish, N Tokuriki, ... Nature communications 11 (1), 3469, 2020 | 60 | 2020 |
A continuum of evolving de novo genes drives protein-coding novelty in Drosophila B Heames, J Schmitz, E Bornberg-Bauer Journal of molecular evolution 88 (4), 382-398, 2020 | 57 | 2020 |
Structural and functional characterization of a putative de novo gene in Drosophila A Lange, PH Patel, B Heames, AM Damry, T Saenger, CJ Jackson, ... Nature communications 12 (1), 1667, 2021 | 40 | 2021 |
Experimental characterization of de novo proteins and their unevolved random-sequence counterparts B Heames, F Buchel, M Aubel, V Tretyachenko, D Loginov, P Novák, ... Nature ecology & evolution 7 (4), 570-580, 2023 | 28 | 2023 |
Dissecting how modular polyketide synthase ketoreductases interact with acyl carrier protein-attached substrates L Moretto, S Vance, B Heames, RW Broadhurst Chemical communications 53 (83), 11457-11460, 2017 | 16 | 2017 |
Becoming a de novo gene E Bornberg-Bauer, B Heames Nature Ecology & Evolution 3 (4), 524-525, 2019 | 10 | 2019 |
High-throughput selection of human de novo-emerged sORFs with high folding potential M Aubel, F Buchel, B Heames, A Jones, O Honc, E Bornberg-Bauer, ... Genome Biology and Evolution, evae069, 2024 | | 2024 |