John Asara
John Asara
Associate Professor Medicine, Harvard Medical School; Director, Beth Israel Deaconess Medical Center
Adresse e-mail validée de bidmc.harvard.edu
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HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
M Ivan, K Kondo, H Yang, W Kim, J Valiando, M Ohh, A Salic, JM Asara, ...
Science 292 (5516), 464-468, 2001
49702001
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
DF Egan, DB Shackelford, MM Mihaylova, S Gelino, RA Kohnz, W Mair, ...
Science 331 (6016), 456-461, 2011
20142011
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
H Ying, AC Kimmelman, CA Lyssiotis, S Hua, GC Chu, ...
Cell 149 (3), 656-670, 2012
13202012
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
J Son, CA Lyssiotis, H Ying, X Wang, S Hua, M Ligorio, RM Perera, ...
Nature 496 (7443), 101-105, 2013
12392013
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation
H Sano, S Kane, E Sano, CP Mı̂inea, JM Asara, WS Lane, CW Garner, ...
Journal of Biological Chemistry 278 (17), 14599-14602, 2003
10902003
Pyruvate kinase M2 is a phosphotyrosine-binding protein
HR Christofk, MG Vander Heiden, N Wu, JM Asara, LC Cantley
Nature 452 (7184), 181-186, 2008
9962008
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
D Anastasiou, G Poulogiannis, JM Asara, MB Boxer, J Jiang, M Shen, ...
Science 334 (6060), 1278-1283, 2011
9282011
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
JW Locasale, AR Grassian, T Melman, CA Lyssiotis, KR Mattaini, AJ Bass, ...
Nature genetics 43 (9), 869-874, 2011
8822011
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
VS LeBleu, JT O’Connell, KNG Herrera, H Wikman, K Pantel, MC Haigis, ...
Nature cell biology 16 (10), 992-1003, 2014
7982014
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
A Viale, P Pettazzoni, CA Lyssiotis, H Ying, N Sánchez, M Marchesini, ...
Nature 514 (7524), 628-632, 2014
7682014
A method to identify serine kinase substrates: Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain
S Kane, H Sano, SCH Liu, JM Asara, WS Lane, CC Garner, GE Lienhard
Journal of Biological Chemistry 277 (25), 22115-22118, 2002
6272002
Evidence for an alternative glycolytic pathway in rapidly proliferating cells
MG Vander Heiden, JW Locasale, KD Swanson, H Sharfi, GJ Heffron, ...
Science 329 (5998), 1492-1499, 2010
6242010
A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue
M Yuan, SB Breitkopf, X Yang, JM Asara
Nature protocols 7 (5), 872, 2012
5912012
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
J Yun, E Mullarky, C Lu, KN Bosch, A Kavalier, K Rivera, J Roper, IIC Chio, ...
Science 350 (6266), 1391-1396, 2015
5472015
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ...
Nature chemical biology 8 (10), 839-847, 2012
5472012
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
CM Sousa, DE Biancur, X Wang, CJ Halbrook, MH Sherman, L Zhang, ...
Nature 536 (7617), 479-483, 2016
5332016
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1
I Ben-Sahra, JJ Howell, JM Asara, BD Manning
Science 339 (6125), 1323-1328, 2013
5142013
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1
CC Dibble, W Elis, S Menon, W Qin, J Klekota, JM Asara, PM Finan, ...
Molecular cell 47 (4), 535-546, 2012
4732012
Influence of threonine metabolism on S-adenosylmethionine and histone methylation
N Shyh-Chang, JW Locasale, CA Lyssiotis, Y Zheng, RY Teo, ...
Science 339 (6116), 222-226, 2013
4602013
Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
CC Dibble, JM Asara, BD Manning
Molecular and cellular biology 29 (21), 5657-5670, 2009
4402009
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