Brian Marsden
Brian Marsden
SGC & Kennedy Institute of Rheumatology
Adresse e-mail validée de sgc.ox.ac.uk - Page d'accueil
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Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
M Vedadi, FH Niesen, A Allali-Hassani, OY Fedorov, PJ Finerty, ...
Proceedings of the National Academy of Sciences 103 (43), 15835-15840, 2006
5832006
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
4822015
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases
O Fedorov, B Marsden, V Pogacic, P Rellos, S Müller, AN Bullock, ...
Proceedings of the National Academy of Sciences 104 (51), 20523-20528, 2007
3552007
High-throughput production of human proteins for crystallization: the SGC experience
P Savitsky, J Bray, CDO Cooper, BD Marsden, P Mahajan, ...
Journal of structural biology 172 (1), 3-13, 2010
2302010
Structures of ABCB10, a human ATP-binding cassette transporter in apo-and nucleotide-bound states
CA Shintre, ACW Pike, Q Li, JI Kim, AJ Barr, S Goubin, L Shrestha, J Yang, ...
Proceedings of the National Academy of Sciences 110 (24), 9710-9715, 2013
2062013
3, 5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands
DS Hewings, M Wang, M Philpott, O Fedorov, S Uttarkar, ...
Journal of medicinal chemistry 54 (19), 6761-6770, 2011
1852011
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit
PV Fish, P Filippakopoulos, G Bish, PE Brennan, ME Bunnage, AS Cook, ...
Journal of medicinal chemistry 55 (22), 9831-9837, 2012
1812012
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases
P Canning, CDO Cooper, T Krojer, JW Murray, ACW Pike, A Chaikuad, ...
Journal of Biological Chemistry 288 (11), 7803-7814, 2013
1692013
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase
AN Bullock, JÉ Debreczeni, OY Fedorov, A Nelson, BD Marsden, S Knapp
Journal of medicinal chemistry 48 (24), 7604-7614, 2005
1692005
The treatment of Wilms' tumour: results of the United Kingdom Children's cancer study group (UKCCSG) second Wilms' tumour study
C Mitchell, PM Jones, A Kelsey, GM Vujanic, B Marsden, R Shannon, ...
British journal of cancer 83 (5), 602-608, 2000
1182000
The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary
JE Bray, BD Marsden, U Oppermann
Chemico-biological interactions 178 (1-3), 99-109, 2009
1122009
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases
NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ...
Journal of medicinal chemistry 55 (14), 6639-6643, 2012
982012
[1,2,4]Triazolo[4,3-a]phthalazines: Inhibitors of Diverse Bromodomains
O Fedorov, H Lingard, C Wells, OP Monteiro, S Picaud, T Keates, C Yapp, ...
Journal of medicinal chemistry 57 (2), 462-476, 2014
792014
A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ...
Nature communications 8 (1), 1-8, 2017
712017
The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins
O Gileadi, S Knapp, WH Lee, BD Marsden, S Müller, FH Niesen, ...
Journal of structural and functional genomics 8 (2-3), 107-119, 2007
702007
ChromoHub: a data hub for navigators of chromatin-mediated signalling
L Liu, XT Zhen, E Denton, BD Marsden, M Schapira
Bioinformatics 28 (16), 2205-2206, 2012
682012
Linking of 2‐oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases
ECY Woon, A Tumber, A Kawamura, L Hillringhaus, W Ge, NR Rose, ...
Angewandte Chemie 124 (7), 1663-1666, 2012
642012
A Novel Allelic Variant of the Human TSG-6 Gene Encoding an Amino Acid Difference in the CUB Module CHROMOSOMAL LOCALIZATION, FREQUENCY ANALYSIS, MODELING, AND EXPRESSION
HA Nentwich, Z Mustafa, MS Rugg, BD Marsden, MR Cordell, ...
Journal of Biological Chemistry 277 (18), 15354-15362, 2002
642002
Insights for the development of specific kinase inhibitors by targeted structural genomics
O Fedorov, M Sundström, B Marsden, S Knapp
Drug discovery today 12 (9-10), 365-372, 2007
632007
A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP (2), an atypical bromodomain
OB Cox, T Krojer, P Collins, O Monteiro, R Talon, A Bradley, O Fedorov, ...
Chemical science 7 (3), 2322-2330, 2016
622016
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