| Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation A Talavera, R Friemann, S Gómez-Puerta, C Martinez-Fleites, G Garrido, ... Cancer research 69 (14), 5851-5859, 2009 | 242 | 2009 |
| Subangstrom resolution X-ray structure details aquaporin-water interactions U Kosinska Eriksson, G Fischer, R Friemann, G Enkavi, E Tajkhorshid, ... science 340 (6138), 1346-1349, 2013 | 228 | 2013 |
| Crystal structure of plant pectin methylesterase K Johansson, M El-Ahmad, R Friemann, H Jörnvall, O Markovič, H Eklund FEBS letters 514 (2-3), 243-249, 2002 | 180 | 2002 |
| Structural snapshots along the reaction pathway of ferredoxin–thioredoxin reductase S Dai, R Friemann, DA Glauser, F Bourquin, W Manieri, P Schürmann, ... Nature 448 (7149), 92-96, 2007 | 156 | 2007 |
| Structural insight into the dioxygenation of nitroarene compounds: the crystal structure of nitrobenzene dioxygenase R Friemann, MM Ivkovic-Jensen, DJ Lessner, CL Yu, DT Gibson, ... Journal of molecular biology 348 (5), 1139-1151, 2005 | 134 | 2005 |
| Transcription factor clusters regulate genes in eukaryotic cells AJM Wollman, S Shashkova, EG Hedlund, R Friemann, S Hohmann, ... Elife 6, e27451, 2017 | 86 | 2017 |
| Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site WY Wahlgren, E Dunevall, RA North, A Paz, M Scalise, P Bisignano, ... Nature Communications 9 (1), 1753, 2018 | 81 | 2018 |
| Structures of the multicomponent Rieske non-heme iron toluene 2, 3-dioxygenase enzyme system R Friemann, K Lee, EN Brown, DT Gibson, H Eklund, S Ramaswamy Acta Crystallographica Section D: Biological Crystallography 65 (1), 24-33, 2009 | 81 | 2009 |
| Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors S Sainas, AC Pippione, E Lupino, M Giorgis, P Circosta, V Gaidano, ... Journal of medicinal chemistry 61 (14), 6034-6055, 2018 | 66 | 2018 |
| Determining Rieske cluster reduction potentials EN Brown, R Friemann, A Karlsson, JV Parales, MMJ Couture, LD Eltis, ... JBIC Journal of Biological Inorganic Chemistry 13, 1301-1313, 2008 | 65 | 2008 |
| Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds S Sainas, AC Pippione, M Giorgis, E Lupino, P Goyal, C Ramondetti, ... European Journal of Medicinal Chemistry 129, 287-302, 2017 | 58 | 2017 |
| Purification, characterization, and crystallization of the components of the nitrobenzene and 2-nitrotoluene dioxygenase enzyme systems RE Parales, R Huang, CL Yu, JV Parales, FKN Lee, DJ Lessner, ... Applied and environmental microbiology 71 (7), 3806-3814, 2005 | 57 | 2005 |
| Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid AC Pippione, IM Carnovale, D Bonanni, M Sini, P Goyal, E Marini, K Pors, ... European Journal of Medicinal Chemistry 150, 930-945, 2018 | 49 | 2018 |
| Inhibitor binding mode and allosteric regulation of Na+-glucose symporters P Bisignano, C Ghezzi, H Jo, NF Polizzi, T Althoff, C Kalyanaraman, ... Nature communications 9 (1), 5245, 2018 | 43 | 2018 |
| Molecular dynamics simulations of a membrane protein− micelle complex in vacuo R Friemann, DSD Larsson, Y Wang, D van der Spoel Journal of the American Chemical Society 131 (46), 16606-16607, 2009 | 39 | 2009 |
| “Just a spoonful of sugar...”: import of sialic acid across bacterial cell membranes RA North, CR Horne, JS Davies, DM Remus, AC Muscroft-Taylor, P Goyal, ... Biophysical Reviews 10, 219-227, 2018 | 38 | 2018 |
| Active site residues controlling substrate specificity in 2-nitrotoluene dioxygenase from Acidovorax sp. strain JS42 KS Lee, JV Parales, R Friemann, RE Parales Journal of Industrial Microbiology and Biotechnology 32 (10), 465-473, 2005 | 38 | 2005 |
| Bioisosteres of indomethacin as inhibitors of aldo-keto reductase 1C3 ML Lolli, IM Carnovale, AC Pippione, WY Wahlgren, D Bonanni, E Marini, ... ACS medicinal chemistry letters 10 (4), 437-443, 2019 | 32 | 2019 |
| Structure of thioredoxin from Trypanosoma brucei brucei R Friemann, H Schmidt, S Ramaswamy, M Forstner, RL Krauth-Siegel, ... FEBS letters 554 (3), 301-305, 2003 | 30 | 2003 |
| Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies AC Pippione, S Sainas, P Goyal, I Fritzson, GC Cassiano, A Giraudo, ... European journal of medicinal chemistry 163, 266-280, 2019 | 29 | 2019 |
Ramaswamy SubramanianDepartment of Biological Sciences and Department of Biomedical Engineering, Purdue UniversityAdresse e-mail validée de purdue.edu
