| A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ... Nature communications 8 (1), 15123, 2017 | 231 | 2017 |
| A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP (2), an atypical bromodomain OB Cox, T Krojer, P Collins, O Monteiro, R Talon, A Bradley, O Fedorov, ... Chemical science 7 (3), 2322-2330, 2016 | 164 | 2016 |
| Gentle, fast and effective crystal soaking by acoustic dispensing PM Collins, JT Ng, R Talon, K Nekrosiute, T Krojer, A Douangamath, ... Acta Crystallographica Section D: Structural Biology 73 (3), 246-255, 2017 | 100 | 2017 |
| The XChemExplorer graphical workflow tool for routine or large-scale protein–ligand structure determination T Krojer, R Talon, N Pearce, P Collins, A Douangamath, J Brandao-Neto, ... Acta Crystallographica Section D: Structural Biology 73 (3), 267-278, 2017 | 96 | 2017 |
| Synthesis and Demonstration of the Biological Relevance of sp3‐rich Scaffolds Distantly Related to Natural Product Frameworks DJ Foley, PGE Craven, PM Collins, RG Doveston, A Aimon, R Talon, ... Chemistry–A European Journal 23 (60), 15227-15232, 2017 | 62 | 2017 |
| Gradual adaptive changes of a protein facing high salt concentrations N Coquelle, R Talon, DH Juers, É Girard, R Kahn, D Madern Journal of molecular biology 404 (3), 493-505, 2010 | 59 | 2010 |
| Achieving a good crystal system for crystallographic X-ray fragment screening PM Collins, A Douangamath, R Talon, A Dias, J Brandão-Neto, T Krojer, ... Methods in enzymology 610, 251-264, 2018 | 46 | 2018 |
| An experimental point of view on hydration/solvation in halophilic proteins R Talon, N Coquelle, D Madern, E Girard Frontiers in microbiology 5, 79632, 2014 | 42 | 2014 |
| Achieving efficient fragment screening at XChem facility at diamond light source A Douangamath, A Powell, D Fearon, PM Collins, R Talon, T Krojer, ... JoVE (Journal of Visualized Experiments), e62414, 2021 | 32 | 2021 |
| The low-cost Shifter microscope stage transforms the speed and robustness of protein crystal harvesting ND Wright, P Collins, L Koekemoer, T Krojer, R Talon, E Nelson, M Ye, ... Acta Crystallographica Section D: Structural Biology 77 (1), 62-74, 2021 | 30 | 2021 |
| Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B TS Mehlman, JT Biel, SM Azeem, ER Nelson, S Hossain, L Dunnett, ... Elife 12, e84632, 2023 | 21 | 2023 |
| Identifying Small‐Molecule Binding Sites for Epigenetic Proteins at Domain–Domain Interfaces D Bowkett, R Talon, C Tallant, C Schofield, F von Delft, S Knapp, G Bruton, ... ChemMedChem 13 (10), 1051-1057, 2018 | 19 | 2018 |
| Using lanthanoid complexes to phase large macromolecular assemblies R Talon, R Kahn, MA Durá, O Maury, FMD Vellieux, B Franzetti, E Girard Journal of synchrotron radiation 18 (1), 74-78, 2011 | 18 | 2011 |
| Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion SL Kidd, E Fowler, T Reinhardt, T Compton, N Mateu, H Newman, ... Chemical Science 11 (39), 10792-10801, 2020 | 16 | 2020 |
| Clicked europium dipicolinate complexes for protein X-ray structure determination R Talon, L Nauton, JL Canet, R Kahn, E Girard, A Gautier Chemical communications 48 (97), 11886-11888, 2012 | 15 | 2012 |
| Influence of divalent cations in the protein crystallization process assisted by lanthanide-based additives A Roux, R Talon, Z Alsalman, S Engilberge, A d’Aléo, S Di Pietro, A Robin, ... Inorganic Chemistry 60 (20), 15208-15214, 2021 | 7 | 2021 |
| A multi-crystal method for extracting obscured signal from crystallographic electron density NM Pearce, AR Bradley, P Collins, T Krojer, RP Nowak, R Talon, ... bioRxiv, 073411, 2016 | 6 | 2016 |
| Novel quaternary structures of the human prion protein globular domain LO Bortot, VL Rangel, FA Pavlovici, K El Omari, A Wagner, ... Biochimie 191, 118-125, 2021 | 4 | 2021 |
| Deliberately Losing Control of C− H Activation Processes in the Design of Small‐Molecule‐Fragment Arrays Targeting Peroxisomal Metabolism R Khan Tareque, S Hassell‐Hart, T Krojer, A Bradley, S Velupillai, ... ChemMedChem 15 (24), 2513-2520, 2020 | 3 | 2020 |
| Human Pleckstrin Homology domain Interacting Protein (PHIP) OB Cox, T Krojer, P Collins, O Monteiro, R Talon, A Bradley, O Fedorov, ... A Target Enabling Package 10, 2016 | 3 | 2016 |
Frank von DelftPrincipal Investigator: Protein Crystallography, SGC, Oxford UniversityAdresse e-mail validée de sgc.ox.ac.uk
