Tommy Alain
Tommy Alain
Children's Hospital of Eastern Ontario Research Institute and University of Ottawa
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mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs
RJO Dowling, I Topisirovic, T Alain, M Bidinosti, BD Fonseca, ...
Science 328 (5982), 1172-1176, 2010
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation
M Morita, SP Gravel, V Chénard, K Sikström, L Zheng, T Alain, V Gandin, ...
Cell metabolism 18 (5), 698-711, 2013
Oncolytic reovirus against ovarian and colon cancer
K Hirasawa, SG Nishikawa, KL Norman, T Alain, A Kossakowska, ...
Cancer research 62 (6), 1696-1701, 2002
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3
N Robichaud, SV del Rincon, B Huor, T Alain, LA Petruccelli, J Hearnden, ...
Oncogene 34 (16), 2032-2042, 2015
Distinct perturbation of the translatome by the antidiabetic drug metformin
O Larsson, M Morita, I Topisirovic, T Alain, MJ Blouin, M Pollak, ...
Proceedings of the National Academy of Sciences 109 (23), 8977-8982, 2012
La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1)
BD Fonseca, C Zakaria, JJ Jia, TE Graber, Y Svitkin, S Tahmasebi, ...
Journal of Biological Chemistry 290 (26), 15996-16020, 2015
Myxoma virus is a novel oncolytic virus with significant antitumor activity against experimental human gliomas
X Lun, W Yang, T Alain, ZQ Shi, H Muzik, JW Barrett, G McFadden, J Bell, ...
Cancer research 65 (21), 9982-9990, 2005
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies
T Alain, M Morita, BD Fonseca, A Yanagiya, N Siddiqui, M Bhat, D Zammit, ...
Cancer research 72 (24), 6468-6476, 2012
Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale
V Gandin, K Sikström, T Alain, M Morita, S McLaughlan, O Larsson, ...
Journal of visualized experiments: JoVE, 2014
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development
M Morita, LW Ler, MR Fabian, N Siddiqui, M Mullin, VC Henderson, ...
Molecular and cellular biology 32 (17), 3585-3593, 2012
Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production
T Alain, XQ Lun, Y Martineau, P Sean, B Pulendran, E Petroulakis, ...
Proceedings of the National Academy of Sciences 107 (4), 1576-1581, 2010
Reovirus therapy of lymphoid malignancies
T Alain, K Hirasawa, KJ Pon, SG Nishikawa, SJ Urbanski, Y Auer, J Luider, ...
Blood, The Journal of the American Society of Hematology 100 (12), 4146-4153, 2002
Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling
BD Fonseca, GH Diering, MA Bidinosti, K Dalal, T Alain, AD Balgi, ...
Journal of Biological Chemistry 287 (21), 17530-17545, 2012
Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling
R Cao, B Robinson, H Xu, C Gkogkas, A Khoutorsky, T Alain, A Yanagiya, ...
Neuron 79 (4), 712-724, 2013
Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death
DJ Mahoney, C Lefebvre, K Allan, J Brun, CA Sanaei, S Baird, N Pearce, ...
Cancer cell 20 (4), 443-456, 2011
La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs
RM Lahr, BD Fonseca, GE Ciotti, HA Al-Ashtal, JJ Jia, MR Niklaus, ...
Elife 6, e24146, 2017
p53-dependent translational control of senescence and transformation via 4E-BPs
E Petroulakis, A Parsyan, RJO Dowling, O LeBacquer, Y Martineau, ...
Cancer cell 16 (5), 439-446, 2009
The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis
A Parsyan, D Shahbazian, Y Martineau, E Petroulakis, T Alain, O Larsson, ...
Proceedings Of The National Academy Of Sciences 106 (52), 22217-22222, 2009
Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by rapamycin
XQ Lun, H Zhou, T Alain, B Sun, L Wang, JW Barrett, MM Stanford, ...
Cancer research 67 (18), 8818-8827, 2007
Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing
GF Deleavey, JK Watts, T Alain, F Robert, A Kalota, V Aishwarya, ...
Nucleic acids research 38 (13), 4547-4557, 2010
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