Suivre
Ralph Scully
Ralph Scully
Professor of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
Adresse e-mail validée de bidmc.harvard.edu
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Association of BRCA1 with Rad51 in mitotic and meiotic cells
R Scully, J Chen, A Plug, Y Xiao, D Weaver, J Feunteun, T Ashley, ...
Cell 88 (2), 265-275, 1997
19011997
Pan-cancer analysis of whole genomes
Nature 578 (7793), 82-93, 2020
1689*2020
Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis
T Ikura, VV Ogryzko, M Grigoriev, R Groisman, J Wang, M Horikoshi, ...
Cell 102 (4), 463-473, 2000
12402000
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
R Scully, J Chen, RL Ochs, K Keegan, M Hoekstra, J Feunteun, ...
Cell 90 (3), 425-435, 1997
12231997
DNA double-strand break repair-pathway choice in somatic mammalian cells
R Scully, A Panday, R Elango, NA Willis
Nature reviews Molecular cell biology 20 (11), 698-714, 2019
11182019
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
P Oberdoerffer, S Michan, M McVay, R Mostoslavsky, J Vann, SK Park, ...
Cell 135 (5), 907-918, 2008
9642008
In search of the tumour-suppressor functions of BRCA1 and BRCA2
R Scully, DM Livingston
Nature 408 (6811), 429-432, 2000
8832000
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
J Chen, DP Silver, D Walpita, SB Cantor, AF Gazdar, G Tomlinson, ...
Molecular cell 2 (3), 317-328, 1998
8051998
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
RS Tibbetts, D Cortez, KM Brumbaugh, R Scully, D Livingston, SJ Elledge, ...
Genes & development 14 (23), 2989-3002, 2000
6962000
Patterns of somatic structural variation in human cancer genomes
Y Li, ND Roberts, JA Wala, O Shapira, SE Schumacher, K Kumar, ...
Nature 578 (7793), 112-121, 2020
6892020
BRCA1 is a component of the RNA polymerase II holoenzyme
R Scully, SF Anderson, DM Chao, W Wei, L Ye, RA Young, DM Livingston, ...
Proceedings of the National Academy of Sciences 94 (11), 5605-5610, 1997
6781997
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
CH Bassing, KF Chua, JA Sekiguchi, H Suh, SR Whitlow, JC Fleming, ...
Proceedings of the National Academy of Sciences 99 (12), 8173-8178, 2002
6672002
The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.
TP Yao, G Ku, N Zhou, R Scully, DM LIvINGSTON
Proceedings of the National Academy of Sciences 93 (20), 10626-10631, 1996
6241996
Mechanisms of double-strand break repair in somatic mammalian cells
AJ Hartlerode, R Scully
Biochemical Journal 423 (2), 157-168, 2009
5462009
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
I Cortés-Ciriano, JJK Lee, R Xi, D Jain, YL Jung, L Yang, D Gordenin, ...
Nature genetics 52 (3), 331-341, 2020
5372020
Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas
CA Wilson, L Ramos, MR Villaseñor, KH Anders, MF Press, K Clarke, ...
Nature genetics 21 (2), 236-240, 1999
5181999
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
E Rheinbay, MM Nielsen, F Abascal, JA Wala, O Shapira, G Tiao, ...
Nature 578 (7793), 102-111, 2020
4992020
Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer
A Juvekar, LN Burga, H Hu, EP Lunsford, YH Ibrahim, J Balmañà, ...
Cancer discovery 2 (11), 1048-1063, 2012
4552012
Genetic analysis of BRCA1 function in a defined tumor cell line
R Scully, S Ganesan, K Vlasakova, J Chen, M Socolovsky, DM Livingston
Molecular cell 4 (6), 1093-1099, 1999
4531999
Role of mammalian Mre11 in classical and alternative nonhomologous end joining
A Xie, A Kwok, R Scully
Nature structural & molecular biology 16 (8), 814-818, 2009
4182009
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