| Genome editing with engineered zinc finger nucleases FD Urnov, EJ Rebar, MC Holmes, HS Zhang, PD Gregory Nature Reviews Genetics 11 (9), 636-646, 2010 | 3023 | 2010 |
| A TALE nuclease architecture for efficient genome editing JC Miller, S Tan, G Qiao, KA Barlow, J Wang, DF Xia, X Meng, ... Nature biotechnology 29 (2), 143-148, 2011 | 2945 | 2011 |
| Highly efficient endogenous human gene correction using designed zinc-finger nucleases FD Urnov, JC Miller, YL Lee, CM Beausejour, JM Rock, S Augustus, ... Nature 435 (7042), 646-651, 2005 | 2175 | 2005 |
| Genetic engineering of human pluripotent cells using TALE nucleases D Hockemeyer, H Wang, S Kiani, CS Lai, Q Gao, JP Cassady, GJ Cost, ... Nature biotechnology 29 (8), 731-734, 2011 | 1552 | 2011 |
| Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases EE Perez, J Wang, JC Miller, Y Jouvenot, KA Kim, O Liu, N Wang, G Lee, ... Nature biotechnology 26 (7), 808-816, 2008 | 1382 | 2008 |
| Distinct factors control histone variant H3. 3 localization at specific genomic regions AD Goldberg, LA Banaszynski, KM Noh, PW Lewis, SJ Elsaesser, ... Cell 140 (5), 678-691, 2010 | 1370 | 2010 |
| Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases D Hockemeyer, F Soldner, C Beard, Q Gao, M Mitalipova, RC DeKelver, ... Nature biotechnology 27 (9), 851-857, 2009 | 1293 | 2009 |
| Knockout rats via embryo microinjection of zinc-finger nucleases AM Geurts, GJ Cost, Y Freyvert, B Zeitler, JC Miller, VM Choi, SS Jenkins, ... Science 325 (5939), 433-433, 2009 | 1204 | 2009 |
| Precise genome modification in the crop species Zea mays using zinc-finger nucleases VK Shukla, Y Doyon, JC Miller, RC DeKelver, EA Moehle, SE Worden, ... Nature 459 (7245), 437-441, 2009 | 1178 | 2009 |
| Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases Y Doyon, JM McCammon, JC Miller, F Faraji, C Ngo, GE Katibah, ... Nature biotechnology 26 (6), 702-708, 2008 | 1151 | 2008 |
| Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery A Lombardo, P Genovese, CM Beausejour, S Colleoni, YL Lee, KA Kim, ... Nature biotechnology 25 (11), 1298-1306, 2007 | 1151 | 2007 |
| Targeted genome editing across species using ZFNs and TALENs AJ Wood, TW Lo, B Zeitler, CS Pickle, EJ Ralston, AH Lee, R Amora, ... Science 333 (6040), 307-307, 2011 | 952 | 2011 |
| Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations F Soldner, J Laganière, AW Cheng, D Hockemeyer, Q Gao, R Alagappan, ... Cell 146 (2), 318-331, 2011 | 927 | 2011 |
| K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates J Straimer, NF Gnädig, B Witkowski, C Amaratunga, V Duru, ... Science 347 (6220), 428-431, 2015 | 769 | 2015 |
| Don’t edit the human germ line E Lanphier, F Urnov, SE Haecker, M Werner, J Smolenski Nature 519 (7544), 410-411, 2015 | 746 | 2015 |
| DNA-binding proteins and uses thereof PD Gregory, JC Miller, D Paschon, EJ Rebar, S Tan, F Urnov, L Zhang US Patent 8,586,526, 2013 | 563 | 2013 |
| Methods and compositions for targeted cleavage and recombination F Urnov, MC Holmes, JC Miller, CO Pabo US Patent 7,888,121, 2011 | 544 | 2011 |
| Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures Y Doyon, TD Vo, MC Mendel, SG Greenberg, J Wang, DF Xia, JC Miller, ... Nature methods 8 (1), 74-79, 2011 | 523 | 2011 |
| Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases EA Moehle, JM Rock, YL Lee, Y Jouvenot, RC DeKelver, PD Gregory, ... Proceedings of the National Academy of Sciences 104 (9), 3055-3060, 2007 | 501 | 2007 |
| Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases Y Santiago, E Chan, PQ Liu, S Orlando, L Zhang, FD Urnov, MC Holmes, ... Proceedings of the National Academy of Sciences 105 (15), 5809-5814, 2008 | 485 | 2008 |
