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R. Luke Wiseman
R. Luke Wiseman
The Scripps research Interest
Verified email at scripps.edu - Homepage
Title
Cited by
Cited by
Year
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
CE Bulawa, S Connelly, M DeVit, L Wang, C Weigel, JA Fleming, ...
Proceedings of the National Academy of Sciences 109 (24), 9629-9634, 2012
7042012
Prevention of transthyretin amyloid disease by changing protein misfolding energetics
P Hammarstrom, RL Wiseman, ET Powers, JW Kelly
Science 299 (5607), 713-716, 2003
5972003
Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments
MD Shoulders, LM Ryno, JC Genereux, JJ Moresco, PG Tu, C Wu, ...
Cell reports 3 (4), 1279-1292, 2013
5292013
The biological and chemical basis for tissue-selective amyloid disease
Y Sekijima, RL Wiseman, J Matteson, P Hammarström, SR Miller, ...
Cell 121 (1), 73-85, 2005
5242005
Targeting protein aggregation for the treatment of degenerative diseases
YS Eisele, C Monteiro, C Fearns, SE Encalada, RL Wiseman, ET Powers, ...
Nature reviews Drug discovery 14 (11), 759-780, 2015
4122015
Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses
SM Johnson, RL Wiseman, Y Sekijima, NS Green, SL Adamski-Werner, ...
Accounts of chemical research 38 (12), 911-921, 2005
3422005
Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action
H Razavi, SK Palaninathan, ET Powers, RL Wiseman, HE Purkey, ...
Angewandte Chemie 115 (24), 2864-2867, 2003
2822003
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
L Plate, CB Cooley, JJ Chen, RJ Paxman, CM Gallagher, F Madoux, ...
elife 5, e15550, 2016
2072016
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1
RL Wiseman, Y Zhang, KPK Lee, HP Harding, CM Haynes, J Price, ...
Molecular cell 38 (2), 291-304, 2010
2072010
The pathway by which the tetrameric protein transthyretin dissociates
TR Foss, RL Wiseman, JW Kelly
Biochemistry 44 (47), 15525-15533, 2005
2042005
The PERK arm of the unfolded protein response regulates mitochondrial morphology during acute endoplasmic reticulum stress
J Lebeau, JM Saunders, VWR Moraes, A Madhavan, N Madrazo, ...
Cell reports 22 (11), 2827-2836, 2018
2032018
Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing
C Puchades, AJ Rampello, M Shin, CJ Giuliano, RL Wiseman, SE Glynn, ...
Science 358 (6363), eaao0464, 2017
2012017
Stress-responsive regulation of mitochondria through the ER unfolded protein response
TK Rainbolt, JM Saunders, RL Wiseman
Trends in Endocrinology & Metabolism 25 (10), 528-537, 2014
1942014
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics
A Carreras-Sureda, F Jana, H Urra, S Durand, DE Mortenson, A Sagredo, ...
Nature cell biology 21 (6), 755-767, 2019
1852019
An adaptable standard for protein export from the endoplasmic reticulum
RL Wiseman, ET Powers, JN Buxbaum, JW Kelly, WE Balch
Cell 131 (4), 809-821, 2007
1772007
Stress-regulated translational attenuation adapts mitochondrial protein import through Tim17A degradation
TK Rainbolt, N Atanassova, JC Genereux, RL Wiseman
Cell metabolism 18 (6), 908-919, 2013
1762013
Reciprocal degradation of YME1L and OMA1 adapts mitochondrial proteolytic activity during stress
TK Rainbolt, J Lebeau, C Puchades, RL Wiseman
Cell reports 14 (9), 2041-2049, 2016
1642016
D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis?
P Hammarström, Y Sekijima, JT White, RL Wiseman, A Lim, CE Costello, ...
Biochemistry 42 (22), 6656-6663, 2003
1582003
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
EA Blackwood, K Azizi, DJ Thuerauf, RJ Paxman, L Plate, JW Kelly, ...
Nature communications 10 (1), 187, 2019
1572019
Unfolded protein response‐induced ER dj3 secretion links ER stress to extracellular proteostasis
JC Genereux, S Qu, M Zhou, LM Ryno, S Wang, MD Shoulders, ...
The EMBO journal 34 (1), 4-19, 2015
1412015
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