Suivre
Derek H. Oakley, M.D., Ph.D.
Derek H. Oakley, M.D., Ph.D.
Instructor in Pathology, Massachusetts General Hospital, Harvard Medical School
Adresse e-mail validée de partners.org
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Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines
C Bock, E Kiskinis, G Verstappen, H Gu, G Boulting, ZD Smith, M Ziller, ...
Cell 144 (3), 439-452, 2011
11422011
A functionally characterized test set of human induced pluripotent stem cells
GL Boulting, E Kiskinis, GF Croft, MW Amoroso, DH Oakley, BJ Wainger, ...
Nature biotechnology 29 (3), 279-286, 2011
5832011
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1
E Kiskinis, J Sandoe, LA Williams, GL Boulting, R Moccia, BJ Wainger, ...
Cell stem cell 14 (6), 781-795, 2014
5032014
Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease
S Dujardin, C Commins, A Lathuiliere, P Beerepoot, AR Fernandes, ...
Nature medicine 26 (8), 1256-1263, 2020
3162020
Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain
KE Van Der Vos, ER Abels, X Zhang, C Lai, E Carrizosa, D Oakley, ...
Neuro-oncology 18 (1), 58-69, 2015
2992015
Accelerated high-yield generation of limb-innervating motor neurons from human stem cells
MW Amoroso, GF Croft, DJ Williams, S O'Keeffe, MA Carrasco, AR Davis, ...
Journal of Neuroscience 33 (2), 574-586, 2013
2932013
Synaptic tau seeding precedes tau pathology in human Alzheimer's disease brain
SL DeVos, BT Corjuc, DH Oakley, CK Nobuhara, RN Bannon, A Chase, ...
Frontiers in neuroscience 12, 267, 2018
2612018
The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease
SC Hopp, Y Lin, D Oakley, AD Roe, SL DeVos, D Hanlon, BT Hyman
Journal of neuroinflammation 15, 1-15, 2018
2442018
Pathological correlations of [F‐18]‐AV‐1451 imaging in non‐alzheimer tauopathies
M Marquié, MD Normandin, AC Meltzer, M Siao Tick Chong, NV Andrea, ...
Annals of neurology 81 (1), 117-128, 2017
2052017
SOD1 Suppression with Adeno-Associated Virus and MicroRNA in Familial ALS
C Mueller, JD Berry, DM McKenna-Yasek, G Gernoux, MA Owegi, ...
New England Journal of Medicine 383 (2), 151-158, 2020
1822020
Somatic genomic changes in single Alzheimer’s disease neurons
MB Miller, AY Huang, J Kim, Z Zhou, SL Kirkham, EA Maury, ...
Nature 604 (7907), 714-722, 2022
1152022
Protein prenylation constitutes an endogenous brake on axonal growth
H Li, T Kuwajima, D Oakley, E Nikulina, J Hou, WS Yang, ER Lowry, ...
Cell reports 16 (2), 545-558, 2016
562016
Novel Compound Heterozygous Mutations Expand the Recognized Phenotypes of FARS2-Linked Disease
MA Walker, KP Mohler, KW Hopkins, DH Oakley, DA Sweetser, M Ibba, ...
Journal of child neurology 31 (9), 1127-1137, 2016
472016
Stem cells in the nervous system
AR Maldonado-Soto, DH Oakley, H Wichterle, J Stein, FK Doetsch, ...
American journal of physical medicine & rehabilitation 93 (11), S132-S144, 2014
432014
A 44‐year‐old man with eye, kidney, and brain dysfunction
I Vodopivec, DH Oakley, CA Perugino, N Venna, ET Hedley‐Whyte, ...
Annals of neurology 79 (4), 507-519, 2016
352016
Targeting tau mitigates mitochondrial fragmentation and oxidative stress in amyotrophic lateral sclerosis
T Petrozziello, EA Bordt, AN Mills, SE Kim, E Sapp, BA Devlin, ...
Molecular neurobiology 59 (1), 683-702, 2022
242022
Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post‐mortem motor cortex and cerebrospinal fluid
T Petrozziello, AC Amaral, S Dujardin, SMK Farhan, J Chan, ...
Brain Pathology 32 (2), e13035, 2022
182022
Assessment of cholesterol homeostasis in the living human brain
A Haider, C Zhao, L Wang, Z Xiao, J Rong, X Xia, Z Chen, SK Pfister, ...
Science translational medicine 14 (665), eadc9967, 2022
172022
Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment
P Kivisäkk, BC Carlyle, T Sweeney, BA Trombetta, K LaCasse, L El-Mufti, ...
Frontiers in Neurology 14, 1069411, 2023
142023
Common mouse models of tauopathy reflect early but not late human disease
K Wenger, A Viode, CN Schlaffner, P van Zalm, L Cheng, T Dellovade, ...
Molecular Neurodegeneration 18 (1), 10, 2023
132023
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