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Kohei Shitara
Kohei Shitara
Adresse e-mail validée de east.ncc.go.jp
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Safety and efficacy of pembrolizumab monotherapy in patients with previously treated advanced gastric and gastroesophageal junction cancer: phase 2 clinical KEYNOTE-059 trial
CS Fuchs, T Doi, RW Jang, K Muro, T Satoh, M Machado, W Sun, SI Jalal, ...
JAMA oncology 4 (5), e180013-e180013, 2018
16302018
First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised …
YY Janjigian, K Shitara, M Moehler, M Garrido, P Salman, L Shen, ...
The Lancet 398 (10294), 27-40, 2021
15862021
Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial
K Shitara, M Özgüroğlu, YJ Bang, M Di Bartolomeo, M Mandalà, MH Ryu, ...
The Lancet 392 (10142), 123-133, 2018
11372018
Regulatory T cells in cancer immunosuppression—implications for anticancer therapy
Y Togashi, K Shitara, H Nishikawa
Nature reviews Clinical oncology 16 (6), 356-371, 2019
11002019
Trastuzumab deruxtecan in previously treated HER2-positive gastric cancer
K Shitara, YJ Bang, S Iwasa, N Sugimoto, MH Ryu, D Sakai, HC Chung, ...
New England Journal of Medicine 382 (25), 2419-2430, 2020
8762020
Efficacy and safety of pembrolizumab or pembrolizumab plus chemotherapy vs chemotherapy alone for patients with first-line, advanced gastric cancer: the KEYNOTE-062 phase 3 …
K Shitara, E Van Cutsem, YJ Bang, C Fuchs, L Wyrwicz, KW Lee, ...
JAMA oncology 6 (10), 1571-1580, 2020
7882020
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
T Kamada, Y Togashi, C Tay, D Ha, A Sasaki, Y Nakamura, E Sato, ...
Proceedings of the National Academy of Sciences 116 (20), 9999-10008, 2019
7822019
Regorafenib plus nivolumab in patients with advanced gastric or colorectal cancer: an open-label, dose-escalation, and dose-expansion phase Ib trial (REGONIVO, EPOC1603)
S Fukuoka, H Hara, N Takahashi, T Kojima, A Kawazoe, M Asayama, ...
Journal of Clinical Oncology 38 (18), 2053-2061, 2020
5742020
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies
S Kumagai, Y Togashi, T Kamada, E Sugiyama, H Nishinakamura, ...
Nature immunology 21 (11), 1346-1358, 2020
5332020
Trastuzumab emtansine versus taxane use for previously treated HER2-positive locally advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma (GATSBY): an …
PC Thuss-Patience, MA Shah, A Ohtsu, E Van Cutsem, JA Ajani, H Castro, ...
The lancet oncology 18 (5), 640-653, 2017
5092017
BRAF mutation is a powerful prognostic factor in advanced and recurrent colorectal cancer
T Yokota, T Ura, N Shibata, D Takahari, K Shitara, M Nomura, C Kondo, ...
British journal of cancer 104 (5), 856-862, 2011
4562011
The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer
YY Janjigian, A Kawazoe, P Yañez, N Li, S Lonardi, O Kolesnik, ...
Nature 600 (7890), 727-730, 2021
4492021
Trifluridine/tipiracil versus placebo in patients with heavily pretreated metastatic gastric cancer (TAGS): a randomised, double-blind, placebo-controlled, phase 3 trial
K Shitara, T Doi, M Dvorkin, W Mansoor, HT Arkenau, A Prokharau, ...
The Lancet Oncology 19 (11), 1437-1448, 2018
4282018
Safety, pharmacokinetics, and antitumour activity of trastuzumab deruxtecan (DS-8201), a HER2-targeting antibody–drug conjugate, in patients with advanced breast and gastric or …
T Doi, K Shitara, Y Naito, A Shimomura, Y Fujiwara, K Yonemori, ...
The Lancet Oncology 18 (11), 1512-1522, 2017
3982017
Nivolumab plus chemotherapy versus placebo plus chemotherapy in patients with HER2-negative, untreated, unresectable advanced or recurrent gastric or gastro-oesophageal …
YK Kang, LT Chen, MH Ryu, DY Oh, SC Oh, HC Chung, KW Lee, T Omori, ...
The Lancet Oncology 23 (2), 234-247, 2022
3582022
Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments
S Kumagai, S Koyama, K Itahashi, T Tanegashima, Y Lin, Y Togashi, ...
Cancer Cell 40 (2), 201-218. e9, 2022
3292022
Assessment of pembrolizumab therapy for the treatment of microsatellite instability–high gastric or gastroesophageal junction cancer among patients in the KEYNOTE-059, KEYNOTE …
J Chao, CS Fuchs, K Shitara, J Tabernero, K Muro, E Van Cutsem, ...
JAMA oncology 7 (6), 895-902, 2021
2512021
LBA6_PR Nivolumab (nivo) plus chemotherapy (chemo) versus chemo as first-line (1L) treatment for advanced gastric cancer/gastroesophageal junction cancer (GC/GEJC)/esophageal …
M Moehler, K Shitara, M Garrido, P Salman, L Shen, L Wyrwicz, ...
Annals of Oncology 31, S1191, 2020
2502020
Clinicopathological features of programmed death ligand 1 expression with tumor-infiltrating lymphocyte, mismatch repair, and Epstein–Barr virus status in a large cohort of …
A Kawazoe, T Kuwata, Y Kuboki, K Shitara, AK Nagatsuma, M Aizawa, ...
Gastric cancer 20, 407-415, 2017
2292017
Ramucirumab with cisplatin and fluoropyrimidine as first-line therapy in patients with metastatic gastric or junctional adenocarcinoma (RAINFALL): a double-blind, randomised …
CS Fuchs, K Shitara, M Di Bartolomeo, S Lonardi, SE Al-Batran, ...
The Lancet Oncology 20 (3), 420-435, 2019
2272019
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