The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia RE Gale, C Green, C Allen, AJ Mead, AK Burnett, RK Hills, DC Linch Blood 111 (5), 2776-2784, 2008 | 769 | 2008 |
Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia N Goardon, E Marchi, A Atzberger, L Quek, A Schuh, S Soneji, P Woll, ... Cancer cell 19 (1), 138-152, 2011 | 550 | 2011 |
Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy A Sanjuan-Pla, IC Macaulay, CT Jensen, PS Woll, TC Luis, A Mead, ... Nature 502 (7470), 232-236, 2013 | 403 | 2013 |
FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with … AJ Mead, DC Linch, RK Hills, K Wheatley, AK Burnett, RE Gale Blood 110 (4), 1262-1270, 2007 | 333 | 2007 |
Persistent malignant stem cells in del (5q) myelodysplasia in remission R Tehranchi, PS Woll, K Anderson, N Buza-Vidas, T Mizukami, AJ Mead, ... New England Journal of Medicine 363 (11), 1025-1037, 2010 | 271 | 2010 |
Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo PS Woll, U Kjällquist, O Chowdhury, H Doolittle, DC Wedge, S Thongjuea, ... Cancer cell 25 (6), 794-808, 2014 | 246 | 2014 |
Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia A Giustacchini, S Thongjuea, N Barkas, PS Woll, BJ Povinelli, CAG Booth, ... Nature medicine 23 (6), 692, 2017 | 200 | 2017 |
Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells C Böiers, J Carrelha, M Lutteropp, S Luc, JCA Green, E Azzoni, PS Woll, ... Cell stem cell 13 (5), 535-548, 2013 | 176 | 2013 |
Distinct myeloid progenitor–differentiation pathways identified through single-cell RNA sequencing R Drissen, N Buza-Vidas, P Woll, S Thongjuea, A Gambardella, ... Nature immunology 17 (6), 666-676, 2016 | 154 | 2016 |
Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells A Grover, A Sanjuan-Pla, S Thongjuea, J Carrelha, A Giustacchini, ... Nature communications 7 (1), 1-12, 2016 | 132 | 2016 |
Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms W Tapper, AV Jones, R Kralovics, AS Harutyunyan, K Zoi, W Leung, ... Nature communications 6 (1), 1-11, 2015 | 130 | 2015 |
The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential S Luc, TC Luis, H Boukarabila, IC Macaulay, N Buza-Vidas, ... Nature immunology 13 (4), 412, 2012 | 130 | 2012 |
Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial RA Mesa, AM Vannucchi, A Mead, M Egyed, A Szoke, A Suvorov, ... The Lancet Haematology 4 (5), e225-e236, 2017 | 114 | 2017 |
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21 A Roy, G Cowan, AJ Mead, S Filippi, G Bohn, A Chaidos, O Tunstall, ... Proceedings of the National Academy of Sciences 109 (43), 17579-17584, 2012 | 113 | 2012 |
Guideline for the diagnosis and management of myelofibrosis JT Reilly, MF McMullin, PA Beer, N Butt, E Conneally, A Duncombe, ... British journal of haematology 158 (4), 453-471, 2012 | 109 | 2012 |
Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate A Grover, E Mancini, S Moore, AJ Mead, D Atkinson, KD Rasmussen, ... Journal of Experimental Medicine 211 (2), 181-188, 2014 | 104 | 2014 |
Genetically distinct leukemic stem cells in human CD34− acute myeloid leukemia are arrested at a hemopoietic precursor-like stage L Quek, GW Otto, C Garnett, L Lhermitte, D Karamitros, B Stoilova, IJ Lau, ... Journal of Experimental Medicine 213 (8), 1513-1535, 2016 | 98 | 2016 |
Germline JAK2 mutation in a family with hereditary thrombocytosis AJ Mead, MJ Rugless, SEW Jacobsen, A Schuh New England Journal of Medicine 366 (10), 967-969, 2012 | 94 | 2012 |
Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways B Psaila, N Barkas, D Iskander, A Roy, S Anderson, N Ashley, VS Caputo, ... Genome biology 17 (1), 1-19, 2016 | 86 | 2016 |
Ruxolitinib vs best available therapy for ET intolerant or resistant to hydroxycarbamide CN Harrison, AJ Mead, A Panchal, S Fox, C Yap, E Gbandi, A Houlton, ... Blood 130 (17), 1889-1897, 2017 | 82 | 2017 |