Suivre
Meredith Irwin
Meredith Irwin
Hospital for Sick Children; Professor, University of Toronto
Adresse e-mail validée de sickkids.ca
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Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
S Basu, NF Totty, MS Irwin, M Sudol, J Downward
Molecular cell 11 (1), 11-23, 2003
10042003
Role for the p53 homologue p73 in E2F-1-induced apoptosis
M Irwin, MC Marin, AC Phillips, RS Seelan, DI Smith, W Liu, ER Flores, ...
Nature 407 (6804), 645-648, 2000
7822000
Comprehensive analysis of hypermutation in human cancer
BB Campbell, N Light, D Fabrizio, M Zatzman, F Fuligni, R de Borja, ...
Cell 171 (5), 1042-1056. e10, 2017
6922017
A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
MC Marin, CA Jost, LA Brooks, MS Irwin, J O'Nions, JA Tidy, N James, ...
Nature genetics 25 (1), 47-54, 2000
6442000
Chemosensitivity linked to p73 function
MS Irwin, K Kondo, MC Marin, LS Cheng, WC Hahn, WG Kaelin
Cancer cell 3 (4), 403-410, 2003
5012003
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
NA Lissy, PK Davis, M Irwin, WG Kaelin, SF Dowdy
Nature 407 (6804), 642-645, 2000
4042000
p53 family update: p73 and p63 develop their own identities
MS Irwin, WG Kaelin
3572001
Neuroblastoma: paradigm for precision medicine
MS Irwin, JR Park
Pediatric Clinics 62 (1), 225-256, 2015
3522015
VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail
AJ Evans, RC Russell, O Roche, TN Burry, JE Fish, VWK Chow, WY Kim, ...
Molecular and cellular biology 27 (1), 157-169, 2007
3282007
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas
AS Guerreiro Stucklin, S Ryall, K Fukuoka, M Zapotocky, A Lassaletta, ...
Nature Communications 10 (1), 4343, 2019
2632019
Viral oncoproteins discriminate between p53 and the p53 homolog p73
MC Marin, CA Jost, MS Irwin, JA DeCaprio, D Caput, WG Kaelin Jr
Molecular and Cellular Biology 18 (11), 6316-6324, 1998
2591998
Regulation of endocytosis via the oxygen-sensing pathway
Y Wang, O Roche, MS Yan, G Finak, AJ Evans, JL Metcalf, BE Hast, ...
Nature medicine 15 (3), 319-324, 2009
2252009
Revised neuroblastoma risk classification system: a report from the Children's Oncology Group
MS Irwin, A Naranjo, FF Zhang, SL Cohn, WB London, JM Gastier-Foster, ...
Journal of Clinical Oncology 39 (29), 3229, 2021
2192021
HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function
LMS Lau, JK Nugent, X Zhao, MS Irwin
Oncogene 27 (7), 997-1003, 2008
2132008
Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell
LM Hansford, AE McKee, L Zhang, RE George, JT Gerstle, PS Thorner, ...
Cancer research 67 (23), 11234-11243, 2007
2072007
NEDD8 pathways in cancer, Sine Quibus Non
IR Watson, MS Irwin, M Ohh
Cancer cell 19 (2), 168-176, 2011
2042011
Oncogenes induce and activate endogenous p73 protein
A Zaika, M Irwin, C Sansome, UM Moll
Journal of Biological Chemistry 276 (14), 11310-11316, 2001
1762001
Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor–mediated upregulation of caveolin-1
Y Wang, O Roche, C Xu, EH Moriyama, P Heir, J Chung, FC Roos, ...
Proceedings of the National Academy of Sciences 109 (13), 4892-4897, 2012
1512012
Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function
IR Watson, A Blanch, DCC Lin, M Ohh, MS Irwin
Journal of biological chemistry 281 (45), 34096-34103, 2006
1402006
Role of the newer p53 family proteins in malignancy
MS Irwin, WG Kaelin
Apoptosis 6, 17-29, 2001
1332001
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