Karen N. Allen

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	All	Since 2016
Citations	5903	2078
h-index	42	23
i10-index	92	61

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Co-authors

Dean TolanProfessor of Biology, Boston UniversityVerified email at bu.edu
Nicholas R. SilvaggiAssociate Professor of Biochemistry, University of Wisconsin-MilwaukeeVerified email at uwm.edu
Jeremiah FarelliPharmaceutical IndustryVerified email at bu.edu
Arnon LavieProfessor, University of Illinois at ChicagoVerified email at uic.edu
Greg PetskoVerified email at brandeis.edu
Patricia BabbittProfessorVerified email at cgl.ucsf.edu
Hua HuangUniversity of Illinois at Urbana-ChampaignVerified email at illinois.edu
Sandor VajdaProfessor of Biomedical Engineering, Boston UniversityVerified email at bu.edu
Dima KozakovAssociate Professor, Department of Applied Mathematics and Statistics, Stony Brook UniversityVerified email at stonybrook.edu
Chetanya PandyaSenior Data Scientist, bluebird bioVerified email at bluebirdbio.com
Adrian WhittyAssociate Professor of Chemistry, Boston UniversityVerified email at bu.edu
Brian ShoichetProfessor of Pharmaceutical Chemistry, University of California, San FranciscoVerified email at cgl.ucsf.edu
Mark HixonMark S Hixon Consulting LLCVerified email at mark-s-hixon-consulting.com
A. Max BurroughsNational Center for Biotechnology InformationVerified email at nih.gov
Aravind LSenior Investigator, National Institutes of HealthVerified email at mail.nih.gov
Lingqi LuoMemorial Sloan Kettering Cancer CenterVerified email at mskcc.org
Frank RaushelTexas A&M UniversityVerified email at tamu.edu
Angela S BakerTGenVerified email at tgen.org
Gregory FarberPenn State, MIT, NIMHVerified email at mail.nih.gov
Andrej SaliUniversity of California, San FranciscoVerified email at salilab.org

Karen N. Allen

Chair and Professor, Department of Chemistry, Boston University

Verified email at bu.edu - Homepage

enzyme mechanisms X-ray crystallography phosphoryl transfer enzyme evolution


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Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes AM Burroughs, KN Allen, D Dunaway-Mariano, L Aravind Journal of molecular biology 361 (5), 1003-1034, 2006	370	2006
The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction SD Lahiri, G Zhang, D Dunaway-Mariano, KN Allen Science 299 (5615), 2067-2071, 2003	358	2003
Phosphoryl group transfer: evolution of a catalytic scaffold KN Allen, D Dunaway-Mariano Trends in biochemical sciences 29 (9), 495-503, 2004	300	2004
Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis BM Koo, G Kritikos, JD Farelli, H Todor, K Tong, H Kimsey, I Wapinski, ... Cell systems 4 (3), 291-305. e7, 2017	195	2017
Structural origin of the high affinity of a chemically evolved lanthanide‐binding peptide M Nitz, M Sherawat, KJ Franz, E Peisach, KN Allen, B Imperiali Angewandte Chemie 116 (28), 3768-3771, 2004	184	2004
The Crystal Structure of Bacillus cereus Phosphonoacetaldehyde Hydrolase: Insight into Catalysis of Phosphorus Bond Cleavage and Catalytic Diversification within the … MC Morais, W Zhang, AS Baker, G Zhang, D Dunaway-Mariano, KN Allen Biochemistry 39 (34), 10385-10396, 2000	150	2000
The enzyme function initiative JA Gerlt, KN Allen, SC Almo, RN Armstrong, PC Babbitt, JE Cronan, ... Biochemistry 50 (46), 9950-9962, 2011	146	2011
Double-lanthanide-binding tags: design, photophysical properties, and NMR applications LJ Martin, MJ Hähnke, M Nitz, J Wöhnert, NR Silvaggi, KN Allen, ... Journal of the American Chemical Society 129 (22), 7106-7113, 2007	146	2007
X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis A Lavie, KN Allen, GA Petsko, D Ringe Biochemistry 33 (18), 5469-5480, 1994	143	1994
The 2.1 Å Structure of Torpedo californica Creatine Kinase Complexed with the ADP-Mg²⁺−NO₃^-−Creatine Transition-State Analogue Complex^, SD Lahiri, PF Wang, PC Babbitt, MJ McLeish, GL Kenyon, KN Allen Biochemistry 41 (47), 13861-13867, 2002	137	2002
Engineering encodable lanthanide-binding tags into loop regions of proteins K Barthelmes, AM Reynolds, E Peisach, HRA Jonker, NJ DeNunzio, ... Journal of the American Chemical Society 133 (4), 808-819, 2011	129	2011
Caught in the Act: The Structure of Phosphorylated β-Phosphoglucomutase from Lactococcus lactis^, SD Lahiri, G Zhang, D Dunaway-Mariano, KN Allen Biochemistry 41 (26), 8351-8359, 2002	125	2002
Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility NR Silvaggi, GE Boldt, MS Hixon, JP Kennedy, S Tzipori, KD Janda, ... Chemistry & biology 14 (5), 533-542, 2007	120	2007
Lanthanide-tagged proteins—an illuminating partnership KN Allen, B Imperiali Current opinion in chemical biology 14 (2), 247-254, 2010	108	2010
Enzyme promiscuity: engine of evolutionary innovation C Pandya, JD Farelli, D Dunaway-Mariano, KN Allen Journal of Biological Chemistry 289 (44), 30229-30236, 2014	104	2014
The origin of the electrostatic perturbation in acetoacetate decarboxylase MC Ho, JF Ménétret, H Tsuruta, KN Allen Nature 459 (7245), 393-397, 2009	99	2009
Markers of fitness in a successful enzyme superfamily KN Allen, D Dunaway-Mariano Current opinion in structural biology 19 (6), 658-665, 2009	95	2009
Snapshots of Catalysis: the Structure of Fructose-1,6-(bis)phosphate Aldolase Covalently Bound to the Substrate Dihydroxyacetone Phosphate^, KH Choi, J Shi, CE Hopkins, DR Tolan, KN Allen Biochemistry 40 (46), 13868-13875, 2001	88	2001
Isotopic exchange plus substrate and inhibition kinetics of D-xylose isomerase do not support a proton-transfer mechanism KN Allen, A Lavie, GK Farber, A Glasfeld, GA Petsko, D Ringe Biochemistry 33 (6), 1481-1487, 1994	87	1994
HAD Superfamily Phosphotransferase Substrate Diversification: Structure and Function Analysis of HAD Subclass IIB Sugar Phosphatase BT4131^, Z Lu, D Dunaway-Mariano, KN Allen Biochemistry 44 (24), 8684-8696, 2005	85	2005

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