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Cavan Kalonia
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Structural characterization of IgG1 mAb aggregates and particles generated under various stress conditions
SN Telikepalli, OS Kumru, C Kalonia, R Esfandiary, SB Joshi, ...
Journal of pharmaceutical sciences 103 (3), 796-809, 2014
1252014
Evaluating the role of the air-solution interface on the mechanism of subvisible particle formation caused by mechanical agitation for an IgG1 mAb
S Ghazvini, C Kalonia, DB Volkin, P Dhar
Journal of pharmaceutical sciences 105 (5), 1643-1656, 2016
722016
Comparison of polysorbate 80 hydrolysis and oxidation on the aggregation of a monoclonal antibody
NR Larson, Y Wei, I Prajapati, A Chakraborty, B Peters, C Kalonia, ...
Journal of Pharmaceutical Sciences 109 (1), 633-639, 2020
702020
Effects of protein conformation, apparent solubility, and protein–protein interactions on the rates and mechanisms of aggregation for an IgG1Monoclonal antibody
C Kalonia, V Toprani, R Toth, N Wahome, I Gabel, CR Middaugh, ...
The Journal of Physical Chemistry B 120 (29), 7062-7075, 2016
602016
Protein adsorption and layer formation at the stainless steel–solution interface mediates shear-induced particle formation for an IgG1 monoclonal antibody
CK Kalonia, F Heinrich, JE Curtis, S Raman, MA Miller, SD Hudson
Molecular pharmaceutics 15 (3), 1319-1331, 2018
592018
Calculating the mass of subvisible protein particles with improved accuracy using microflow imaging data
C Kalonia, OS Kumru, VI Prajapati, R Mathaes, J Engert, S Zhou, ...
Journal of pharmaceutical sciences 104 (2), 536-547, 2015
512015
Radar chart array analysis to visualize effects of formulation variables on IgG1 particle formation as measured by multiple analytical techniques
C Kalonia, OS Kumru, JH Kim, CR Middaugh, DB Volkin
Journal of pharmaceutical sciences 102 (12), 4256-4267, 2013
412013
Recent advances in studying interfacial adsorption of bioengineered monoclonal antibodies
P Hollowell, Z Li, X Hu, S Ruane, C Kalonia, CF van der Walle, JR Lu
Molecules 25 (9), 2047, 2020
232020
Understanding the stabilizing effect of histidine on mAb aggregation: a molecular dynamics study
S Saurabh, C Kalonia, Z Li, P Hollowell, T Waigh, P Li, J Webster, ...
Molecular Pharmaceutics 19 (9), 3288-3303, 2022
212022
The impact of the metal interface on the stability and quality of a therapeutic fusion protein
AP Defante, CK Kalonia, E Keegan, SM Bishop, HA Satish, SD Hudson, ...
Molecular Pharmaceutics 17 (2), 569-578, 2020
152020
Interfacial adsorption of a monoclonal antibody and its fab and fc fragments at the oil/water interface
S Ruane, Z Li, M Campana, X Hu, H Gong, JRP Webster, F Uddin, ...
Langmuir 35 (42), 13543-13552, 2019
152019
Cis/trans isomerization of unsaturated fatty acids in polysorbate 80 during light exposure of a monoclonal antibody–containing formulation
I Prajapati, BH Peters, NR Larson, Y Wei, S Choudhary, C Kalonia, ...
Journal of Pharmaceutical Sciences 109 (1), 603-613, 2020
142020
Investigating the Orientation of an Interfacially Adsorbed Monoclonal Antibody and Its Fragments Using Neutron Reflection
S Ruane, Z Li, P Hollowell, A Hughes, J Warwicker, JRP Webster, ...
Molecular Pharmaceutics 20 (3), 1643-1656, 2023
32023
Structure and interaction of therapeutic proteins in solution: a combined simulation and experimental study
S Saurabh, Z Li, P Hollowell, T Waigh, P Li, J Webster, JM Seddon, ...
Molecular Physics 121 (19-20), e2236248, 2023
22023
Competitive Adsorption of a Monoclonal Antibody and Nonionic Surfactant at the PDMS/Water Interface
K Shen, X Hu, Z Li, M Liao, Z Zhuang, S Ruane, Z Wang, P Li, S Micciulla, ...
Molecular Pharmaceutics 20 (5), 2502-2512, 2023
22023
Mechanistic Insights into the Adsorption of Monoclonal Antibodies at the Water/Vapor Interface
S Saurabh, Q Zhang, Z Li, JM Seddon, C Kalonia, JR Lu, F Bresme
Molecular Pharmaceutics 21 (2), 704-717, 2024
12024
Conformational changes and drivers of monoclonal antibody liquid-liquid phase separation
NR Larson, Y Wei, TA Cruz, R Esfandiary, CK Kalonia, ML Forrest, ...
Journal of pharmaceutical sciences 112 (3), 680-690, 2023
12023
Visible Light Degradation of a Monoclonal Antibody in a High-Concentration Formulation: Characterization of a Tryptophan-Derived Chromophoric Photo-product by Comparison to …
I Prajapati, NR Larson, S Choudhary, C Kalonia, S Hudak, R Esfandiary, ...
Molecular Pharmaceutics 18 (9), 3223-3234, 2021
12021
Unraveling the Microscopic Mechanism of Molecular Ion Interaction with Monoclonal Antibodies: Impact on Protein Aggregation
S Saurabh, Q Zhang, JM Seddon, JR Lu, C Kalonia, F Bresme
Molecular Pharmaceutics, 2024
2024
The impact of the metal interface on the
AP Defante, CK Kalonia, E Keegan, SM Bishop, HA Satish, SD Hudson
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