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Joseph Racca
Joseph Racca
Indiana University School of Medicine
Adresse e-mail validée de iu.edu
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Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
H Xu, C Faber, T Uchiki, JW Fairman, J Racca, C Dealwis
Proceedings of the National Academy of Sciences 103 (11), 4022-4027, 2006
892006
Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly
H Xu, C Faber, T Uchiki, J Racca, C Dealwis
Proceedings of the National Academy of Sciences 103 (11), 4028-4033, 2006
862006
Inherited human sex reversal due to impaired nucleocytoplasmic trafficking of SRY defines a male transcriptional threshold
YS Chen, JD Racca, NB Phillips, MA Weiss
Proceedings of the National Academy of Sciences 110 (38), E3567-E3576, 2013
322013
Sml1p is a dimer in solution: characterization of denaturation and renaturation of recombinant Sml1p
V Gupta, CB Peterson, LT Dice, T Uchiki, J Racca, J Guo, Y Xu, R Hettich, ...
Biochemistry 43 (26), 8568-8578, 2004
212004
Structure-Function Relationships in Human Testis-determining Factor SRY: AN AROMATIC BUTTRESS UNDERLIES THE SPECIFIC DNA-BENDING SURFACE OF A HIGH MOBILITY GROUP (HMG) BOX*♦
JD Racca, YS Chen, JD Maloy, N Wickramasinghe, NB Phillips, MA Weiss
Journal of Biological Chemistry 289 (47), 32410-32429, 2014
202014
Mammalian testis-determining factor SRY and the enigma of inherited human sex reversal: frustrated induced fit in a bent protein-DNA complex
NB Phillips, J Racca, YS Chen, R Singh, A Jancso-Radek, JT Radek, ...
Journal of Biological Chemistry 286 (42), 36787-36807, 2011
202011
Microsatellite-encoded domain in rodent Sry functions as a genetic capacitor to enable the rapid evolution of biological novelty
YS Chen, JD Racca, PW Sequeira, NB Phillips, MA Weiss
Proceedings of the National Academy of Sciences 110 (33), E3061-E3070, 2013
182013
Human sex determination at the edge of ambiguity: inherited XY sex reversal due to enhanced ubiquitination and proteasomal degradation of a master transcription factor
JD Racca, YS Chen, Y Yang, NB Phillips, MA Weiss
Journal of Biological Chemistry 291 (42), 22173-22195, 2016
132016
Tenuous transcriptional threshold of human sex determination. II. SRY exploits water-mediated clamp at the edge of ambiguity
JD Racca, D Chatterjee, YS Chen, RK Rai, Y Yang, MM Georgiadis, ...
Frontiers in Endocrinology 13, 1029177, 2022
12022
Tenuous transcriptional threshold of human sex determination. i. sry and swyer syndrome at the edge of ambiguity
YS Chen, JD Racca, MA Weiss
Frontiers in Endocrinology 13, 945030, 2022
12022
Inherited human xy sex reversal and gonadal neoplasia due to enhanced formation of non-specific enhanceosomes by an architectural transcription factor
YS Chen, JD Racca, A Belgorosky, MA Weiss
Journal of the Endocrine Society 5 (Suppl 1), A506, 2021
12021
Inherited Human Sex Reversal due to Loss of a Water-Mediated Hydrogen Bond at a Conserved Protein-DNA Interface
YS Chen, J Racca, D Amir, E Haas, MA Weiss
bioRxiv, 2021.05. 05.442830, 2021
2021
SUN-712 Familial 46, XY Complete Female External Sex Development with a Non-Mosaic Inherited SRY Gene Variation
E Vaiani, YS Chen, P Ramirez, MS Baquedano, M Malosetti, J Racca, ...
Journal of the Endocrine Society 4 (Supplement_1), SUN-712, 2020
2020
OR15-5 Human Sex Determination at the Edge of Ambiguity: Impaired SRY Phosphorylation Attenuates Expression of the Male Program
YS Chen, J Racca, N Phillips, M Weiss
Journal of the Endocrine Society 3 (Supplement_1), OR15-5, 2019
2019
Human Sex Determination at the Edge of Ambiguity: Biophysical Studies of Clinical Mutations in a Master Transcription Factor
MA Weiss, YS Chen, J Racca, NB Phillips
Biophysical Journal 112 (3), 516a, 2017
2017
“Protein Un‐Design”: Evolutionary Origins of Native DNA‐Binding Architectures in Unfolded Polypeptides
MA Weiss, JD Racca, YS Chen, NB Phillips
The FASEB Journal 29, 563.12, 2015
2015
Kinetic Control of a Developmental Switch: Design of a “Kinetic Rheostat” in a Bent Protein‐DNA Complex with Application to Human Sex Reversal
JD Racca, YS Chen, V Bhatnagar, NB Phillips, MA Weiss
The FASEB Journal 29, 880.21, 2015
2015
" Experiments of Nature": Structure-function Studies of an Architectural Transcription Factor: Application to Male Sex Determination
JD Racca
Case Western Reserve University, 2015
2015
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