| Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF‐C/D receptor VEGFR‐3 T Mäkinen, T Veikkola, S Mustjoki, T Karpanen, B Catimel, EC Nice, ... The EMBO journal, 2001 | 1130 | 2001 |
| Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth T Karpanen, M Egeblad, MJ Karkkainen, H Kubo, S Ylä-Herttuala, ... Cancer research 61 (5), 1786-1790, 2001 | 1043 | 2001 |
| Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3 T Mäkinen, L Jussila, T Veikkola, T Karpanen, MI Kettunen, KJ Pulkkanen, ... Nature medicine 7 (2), 199-205, 2001 | 1027 | 2001 |
| Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice T Veikkola, L Jussila, T Makinen, T Karpanen, M Jeltsch, TV Petrova, ... The EMBO journal 20 (6), 1223-1231, 2001 | 920 | 2001 |
| Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver … Y Zhou, M McMaster, K Woo, M Janatpour, J Perry, T Karpanen, K Alitalo, ... The American journal of pathology 160 (4), 1405-1423, 2002 | 850 | 2002 |
| Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling Y He, K Kozaki, T Karpanen, K Koshikawa, S Yla-Herttuala, T Takahashi, ... Journal of the National Cancer Institute 94 (11), 819-825, 2002 | 720 | 2002 |
| Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis TV Petrova, T Karpanen, C Norrmén, R Mellor, T Tamakoshi, D Finegold, ... Nature medicine 10 (9), 974-981, 2004 | 649 | 2004 |
| Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers SA Stacker, K Stenvers, C Caesar, A Vitali, T Domagala, E Nice, S Roufail, ... Journal of Biological Chemistry 274 (45), 32127-32136, 1999 | 448 | 1999 |
| Molecular biology and pathology of lymphangiogenesis T Karpanen, K Alitalo Annu. Rev. Pathol. Mech. Dis. 3, 367-397, 2008 | 434 | 2008 |
| Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis A Saaristo, T Karpanen, K Alitalo Oncogene 19 (53), 6122-6129, 2000 | 425 | 2000 |
| Functional interaction of VEGF‐C and VEGF‐D with neuropilin receptors T Karpanen, CA Heckman, S Keskitalo, M Jeltsch, H Ollila, G Neufeld, ... The FASEB Journal 20 (9), 1462-1472, 2006 | 388 | 2006 |
| VEGF‐C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF‐7 tumors MMT Mattila, JK Ruohola, T Karpanen, DG Jackson, K Alitalo, ... International journal of cancer 98 (6), 946-951, 2002 | 374 | 2002 |
| Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1 T Makinen, B Olofsson, T Karpanen, U Hellman, S Soker, M Klagsbrun, ... Journal of Biological Chemistry 274 (30), 21217-21222, 1999 | 370 | 1999 |
| Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells P Laakkonen, ME Åkerman, H Biliran, M Yang, F Ferrer, T Karpanen, ... Proceedings of the National Academy of Sciences 101 (25), 9381-9386, 2004 | 365 | 2004 |
| Role of lymphangiogenic factors in tumor metastasis Y He, T Karpanen, K Alitalo Biochimica Et Biophysica Acta (BBA)-Reviews on Cancer 1654 (1), 3-12, 2004 | 320 | 2004 |
| Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin B Enholm, T Karpanen, M Jeltsch, H Kubo, F Stenback, R Prevo, ... Circulation research 88 (6), 623-629, 2001 | 302 | 2001 |
| PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis M Uutela, M Wirzenius, K Paavonen, I Rajantie, Y He, T Karpanen, ... Blood 104 (10), 3198-3204, 2004 | 264 | 2004 |
| CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C … M Jeltsch, SK Jha, D Tvorogov, A Anisimov, VM Leppänen, T Holopainen, ... Circulation 129 (19), 1962-1971, 2014 | 258 | 2014 |
| CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo FL Bos, M Caunt, J Peterson-Maduro, L Planas-Paz, J Kowalski, ... Circulation research 109 (5), 486-491, 2011 | 243 | 2011 |
| Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis L Le Guen, T Karpanen, D Schulte, NC Harris, K Koltowska, G Roukens, ... Development 141 (6), 1239-1249, 2014 | 188 | 2014 |
Michael JeltschUniversity of HelsinkiAdresse e-mail validée de helsinki.fi
