Tom Dunkley
Tom Dunkley
Lab Head Mass Spectrometry, Roche Innovation Center Basel @ pRED
Adresse e-mail validée de roche.com
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Mapping the Arabidopsis organelle proteome
TPJ Dunkley, S Hester, IP Shadforth, J Runions, T Weimar, SL Hanton, ...
Proceedings of the National Academy of Sciences 103 (17), 6518-6523, 2006
5602006
Localization of organelle proteins by isotope tagging (LOPIT)
TPJ Dunkley, R Watson, JL Griffin, P Dupree, KS Lilley
Molecular & Cellular Proteomics 3 (11), 1128-1134, 2004
3432004
A systematic approach to modeling, capturing, and disseminating proteomics experimental data
CF Taylor, NW Paton, KL Garwood, PD Kirby, DA Stead, Z Yin, ...
Nature biotechnology 21 (3), 247-254, 2003
3012003
i-Tracker: For quantitative proteomics using iTRAQ™
IP Shadforth, TPJ Dunkley, KS Lilley, C Bessant
BMC genomics 6 (1), 1-6, 2005
2962005
Growth control of the eukaryote cell: a systems biology study in yeast
JI Castrillo, LA Zeef, DC Hoyle, N Zhang, A Hayes, DCJ Gardner, ...
Journal of biology 6 (2), 1-25, 2007
2752007
Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics
N Nikolovski, D Rubtsov, MP Segura, GP Miles, TJ Stevens, TPJ Dunkley, ...
Plant physiology 160 (2), 1037-1051, 2012
1512012
Quantitative proteomic approach to study subcellular localization of membrane proteins
PG Sadowski, TPJ Dunkley, IP Shadforth, P Dupree, C Bessant, JL Griffin, ...
Nature protocols 1 (4), 1778, 2006
912006
The use of isotope-coded affinity tags (ICAT) to study organelle proteomes in Arabidopsis thaliana
TPJ Dunkley, P Dupree, RB Watson, KS Lilley
Biochemical Society Transactions 32 (3), 520-523, 2004
762004
Targeted profiling of polar intracellular metabolites using ion-pair-high performance liquid chromatography and-ultra high performance liquid chromatography coupled to tandem …
F Michopoulos, N Whalley, G Theodoridis, ID Wilson, TPJ Dunkley, ...
Journal of Chromatography A 1349, 60-68, 2014
652014
AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo
SA Loddick, SJ Ross, AG Thomason, DM Robinson, GE Walker, ...
Molecular cancer therapeutics 12 (9), 1715-1727, 2013
642013
mTORC1 inhibition corrects neurodevelopmental and synaptic alterations in a human stem cell model of tuberous sclerosis
V Costa, S Aigner, M Vukcevic, E Sauter, K Behr, M Ebeling, T Dunkley, ...
Cell reports 15 (1), 86-95, 2016
622016
Improved sub‐cellular resolution via simultaneous analysis of organelle proteomics data across varied experimental conditions
MWB Trotter, PG Sadowski, TPJ Dunkley, AJ Groen, KS Lilley
Proteomics 10 (23), 4213-4219, 2010
442010
Proteomics sample preparation
J von Hagen
John Wiley & Sons, 2008
442008
Quantitative ADME proteomics–CYP and UGT enzymes in the beagle dog liver and intestine
AT Heikkinen, A Friedlein, M Matondo, OJD Hatley, A Petsalo, R Juvonen, ...
Pharmaceutical research 32 (1), 74-90, 2015
362015
Confident protein identification using the average peptide score method coupled with search‐specific, ab initio thresholds
I Shadforth, T Dunkley, K Lilley, D Crowther, C Bessant
Rapid Communications in Mass Spectrometry: An International Journal Devoted …, 2005
312005
N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related …
C Chen, E Melo, P Jakob, A Friedlein, B Elsässer, P Goettig, V Kueppers, ...
Matrix Biology 70, 84-101, 2018
172018
Characterization of a human pluripotent stem cell‐derived model of neuronal development using multiplexed targeted proteomics
T Dunkley, V Costa, A Friedlein, S Lugert, S Aigner, M Ebeling, MT Miller, ...
PROTEOMICS–Clinical Applications 9 (7-8), 684-694, 2015
152015
Determination of genuine residents of plant endomembrane organelles using isotope tagging and multivariate statistics
KS Lilley, TPJ Dunkley
Organelle Proteomics, 373-387, 2008
152008
HtrA1 mediated intracellular effects on tubulin using a polarized RPE disease model
E Melo, P Oertle, C Trepp, H Meistermann, T Burgoyne, L Sborgi, ...
EBioMedicine 27, 258-274, 2018
132018
HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication
AC Cabrera, E Melo, D Roth, A Topp, F Delobel, C Stucki, C Chen, ...
Scientific reports 7 (1), 1-11, 2017
132017
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