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Dan S Tawfik
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Man-made cell-like compartments for molecular evolution
DS Tawfik, AD Griffiths
Nature biotechnology 16 (7), 652-656, 1998
13941998
Kemp elimination catalysts by computational enzyme design
D Röthlisberger, O Khersonsky, AM Wollacott, L Jiang, J DeChancie, ...
Nature 453 (7192), 190-195, 2008
13662008
Enzyme promiscuity: a mechanistic and evolutionary perspective
OKDS Tawfik
Annual review of biochemistry 79, 471-505, 2010
12432010
The'evolvability'of promiscuous protein functions
A Aharoni, L Gaidukov, O Khersonsky, SMQ Gould, C Roodveldt, ...
Nature genetics 37 (1), 73-76, 2005
9262005
Protein dynamism and evolvability
N Tokuriki, DS Tawfik
Science 324 (5924), 203-207, 2009
8402009
The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters
A Bar-Even, E Noor, Y Savir, W Liebermeister, D Davidi, DS Tawfik, ...
Biochemistry 50 (21), 4402-4410, 2011
8392011
Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes
M Harel, A Aharoni, L Gaidukov, B Brumshtein, O Khersonsky, R Meged, ...
Nature structural & molecular biology 11 (5), 412-419, 2004
7972004
Antibody multispecificity mediated by conformational diversity
LC James, P Roversi, DS Tawfik
Science 299 (5611), 1362-1367, 2003
7812003
Stability effects of mutations and protein evolvability
N Tokuriki, DS Tawfik
Current opinion in structural biology 19 (5), 596-604, 2009
7582009
Enzyme promiscuity: evolutionary and mechanistic aspects
O Khersonsky, C Roodveldt, DS Tawfik
Current opinion in chemical biology 10 (5), 498-508, 2006
6962006
Conformational diversity and protein evolution–a 60-year-old hypothesis revisited
LC James, DS Tawfik
Trends in biochemical sciences 28 (7), 361-368, 2003
6262003
Miniaturising the laboratory in emulsion droplets
AD Griffiths, DS Tawfik
Trends in biotechnology 24 (9), 395-402, 2006
5152006
Amplification of complex gene libraries by emulsion PCR
R Williams, SG Peisajovich, OJ Miller, S Magdassi, DS Tawfik, AD Griffiths
Nature methods 3 (7), 545-550, 2006
5102006
How protein stability and new functions trade off
N Tokuriki, F Stricher, L Serrano, DS Tawfik
PLoS computational biology 4 (2), e1000002, 2008
5072008
Structure− reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase
O Khersonsky, DS Tawfik
Biochemistry 44 (16), 6371-6382, 2005
4932005
In vitro sorting method
A Griffiths, D Tawfik
US Patent 7,638,276, 2009
473*2009
Robustness–epistasis link shapes the fitness landscape of a randomly drifting protein
S Bershtein, M Segal, R Bekerman, N Tokuriki, DS Tawfik
Nature 444 (7121), 929-932, 2006
4262006
Directed evolution of an extremely fast phosphotriesterase by in vitro compartmentalization
AD Griffiths, DS Tawfik
The EMBO journal 22 (1), 24-35, 2003
4122003
Mutational effects and the evolution of new protein functions
M Soskine, DS Tawfik
Nature Reviews Genetics 11 (8), 572-582, 2010
3962010
The stability effects of protein mutations appear to be universally distributed
N Tokuriki, F Stricher, J Schymkowitz, L Serrano, DS Tawfik
Journal of molecular biology 369 (5), 1318-1332, 2007
3812007
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