Gerburg Wulf
Gerburg Wulf
Associate Professor in Medicine, Harvard Medical School
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The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein
PJ Lu, G Wulf, XZ Zhou, P Davies, KP Lu
Nature 399 (6738), 784-788, 1999
Regulation of NF-κB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA
A Ryo, F Suizu, Y Yoshida, K Perrem, YC Liou, G Wulf, R Rottapel, ...
Molecular cell 12 (6), 1413-1426, 2003
Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c‐Jun towards cyclin D1
GM Wulf, A Ryo, GG Wulf, SW Lee, T Niu, V Petkova, KP Lu
The EMBO journal 20 (13), 3459-3472, 2001
Pin1 regulates turnover and subcellular localization of β-catenin by inhibiting its interaction with APC
A Ryo, M Nakamura, G Wulf, YC Liou, KP Lu
Nature cell biology 3 (9), 793-801, 2001
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production
L Pastorino, A Sun, PJ Lu, XZ Zhou, M Balastik, G Finn, G Wulf, J Lim, ...
Nature 440 (7083), 528-534, 2006
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response
H Zheng, H You, XZ Zhou, SA Murray, T Uchida, G Wulf, L Gu, X Tang, ...
Nature 419 (6909), 849-853, 2002
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
WJ Israelsen, TL Dayton, SM Davidson, BP Fiske, AM Hosios, G Bellinger, ...
Cell 155 (2), 397-409, 2013
Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer
A Juvekar, LN Burga, H Hu, EP Lunsford, YH Ibrahim, J Balmañà, ...
Cancer discovery 2 (11), 1048-1063, 2012
PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells
A Ryo, YC Liou, G Wulf, M Nakamura, SW Lee, KP Lu
Molecular and cellular biology 22 (15), 5281-5295, 2002
The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer
G Ayala, D Wang, G Wulf, A Frolov, R Li, J Sowadski, TM Wheeler, KP Lu, ...
Cancer research 63 (19), 6244-6251, 2003
Phosphorylation-specific prolyl isomerization: is there an underlying theme?
G Wulf, G Finn, F Suizu, KP Lu
Nature cell biology 7 (5), 435-441, 2005
Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage
GM Wulf, YC Liou, A Ryo, SW Lee, KP Lu
Journal of Biological Chemistry 277 (50), 47976-47979, 2002
Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer
A Ryo, YC Liou, KP Lu, G Wulf
Journal of cell science 116 (5), 773-783, 2003
Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy
PK Morrow, GM Wulf, J Ensor, DJ Booser, JA Moore, PR Flores, Y Xiong, ...
Journal of Clinical Oncology 29 (23), 3126, 2011
Phosphoinositide 3-kinase regulates glycolysis through mobilization of aldolase from the actin cytoskeleton
H Hu, A Juvekar, CA Lyssiotis, EC Lien, JG Albeck, D Oh, G Varma, ...
Cell 164 (3), 433-446, 2016
Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis
G Wulf, P Garg, YC Liou, D Iglehart, KP Lu
The EMBO journal 23 (16), 3397-3407, 2004
Inhibition of hematopoiesis by competitive binding of transcription factor PU. 1
MT Voso, TC Burn, G Wulf, B Lim, G Leone, DG Tenen
Proceedings of the National Academy of Sciences 91 (17), 7932-7936, 1994
Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism
XZ Zhou, PJ Lu, G Wulf, KP Lu
Cellular and Molecular Life Sciences CMLS 56 (9), 788-806, 1999
cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins.
JM Lelias, CN Adra, GM Wulf, JC Guillemot, M Khagad, D Caput, B Lim
Proceedings of the National Academy of Sciences 90 (4), 1479-1483, 1993
PARP inhibitor efficacy depends on CD8+ T-cell recruitment via intratumoral STING pathway activation in BRCA-deficient models of triple-negative breast cancer
C Pantelidou, O Sonzogni, MDO Taveira, AK Mehta, A Kothari, D Wang, ...
Cancer discovery 9 (6), 722-737, 2019
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