Matthew Frieman
Matthew Frieman
Associate professor, University of Maryland School of Medicine
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Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists
SA Kopecky-Bromberg, L Martínez-Sobrido, M Frieman, RA Baric, ...
Journal of virology 81 (2), 548-557, 2007
Phase 1–2 trial of a SARS-CoV-2 recombinant spike protein nanoparticle vaccine
C Keech, G Albert, I Cho, A Robertson, P Reed, S Neal, JS Plested, M Zhu, ...
New England Journal of Medicine 383 (24), 2320-2332, 2020
Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection
J Dyall, CM Coleman, T Venkataraman, MR Holbrook, J Kindrachuk, ...
Antimicrobial agents and chemotherapy 58 (8), 4885-4893, 2014
Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane
M Frieman, B Yount, M Heise, SA Kopecky-Bromberg, P Palese, RS Baric
Journal of virology 81 (18), 9812-9824, 2007
Bats and coronaviruses
A Banerjee, K Kulcsar, V Misra, M Frieman, K Mossman
Viruses 11 (1), 41, 2019
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail
J Hansen, A Baum, KE Pascal, V Russo, S Giordano, E Wloga, BO Fulton, ...
Science 369 (6506), 1010-1014, 2020
Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain
MG Wathelet, M Orr, MB Frieman, RS Baric
Journal of virology 81 (21), 11620-11633, 2007
Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-κB signaling
M Frieman, K Ratia, RE Johnston, AD Mesecar, RS Baric
Journal of virology 83 (13), 6689-6705, 2009
Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice
B Yount, RS Roberts, AC Sims, D Deming, MB Frieman, J Sparks, ...
Journal of virology 79 (23), 14909-14922, 2005
Animal models for COVID-19
C Muñoz-Fontela, WE Dowling, SGP Funnell, PS Gsell, AX Riveros-Balta, ...
Nature 586 (7830), 509-515, 2020
Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis
J Kindrachuk, B Ork, S Mazur, MR Holbrook, MB Frieman, D Traynor, ...
Antimicrobial agents and chemotherapy 59 (2), 1088-1099, 2015
Selective naked-eye detection of SARS-CoV-2 mediated by N gene targeted antisense oligonucleotide capped plasmonic nanoparticles
P Moitra, M Alafeef, K Dighe, MB Frieman, D Pan
ACS nano 14 (6), 7617-7627, 2020
Evidence supporting a zoonotic origin of human coronavirus strain NL63
J Huynh, S Li, B Yount, A Smith, L Sturges, JC Olsen, J Nagel, ...
Journal of virology 86 (23), 12816-12825, 2012
Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection
KA Kulcsar, CM Coleman, SE Beck, MB Frieman
JCI insight 4 (20), 2019
Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice
CM Coleman, YV Liu, H Mu, JK Taylor, M Massare, DC Flyer, GM Glenn, ...
Vaccine 32 (26), 3169-3174, 2014
A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes
LZ Strichman-Almashanu, RS Lee, PO Onyango, E Perlman, F Flam, ...
Genome research 12 (4), 543-554, 2002
Insights from nanomedicine into chloroquine efficacy against COVID-19
TY Hu, M Frieman, J Wolfram
Nature nanotechnology 15 (4), 247-249, 2020
Metagenomic analysis of the viromes of three North American bat species: viral diversity among different bat species that share a common habitat
EF Donaldson, AN Haskew, JE Gates, J Huynh, CJ Moore, MB Frieman
Journal of virology 84 (24), 13004-13018, 2010
SARS coronavirus and innate immunity
M Frieman, M Heise, R Baric
Virus research 133 (1), 101-112, 2008
Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays
BJ Hart, J Dyall, E Postnikova, H Zhou, J Kindrachuk, RF Johnson, ...
The Journal of general virology 95 (Pt 3), 571, 2014
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