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Hiruy Meharena
Hiruy Meharena
Assistant Professor UC San Diego
Adresse e-mail validée de mit.edu - Page d'accueil
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Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals
M Tizzano, BD Gulbransen, A Vandenbeuch, TR Clapp, JP Herman, ...
Proceedings of the National Academy of Sciences 107 (7), 3210-3215, 2010
4472010
Allosteric activation of functionally asymmetric RAF kinase dimers
J Hu, EC Stites, H Yu, EA Germino, HS Meharena, PJS Stork, AP Kornev, ...
Cell 154 (5), 1036-1046, 2013
3052013
Deciphering the structural basis of eukaryotic protein kinase regulation
HS Meharena, P Chang, MM Keshwani, K Oruganty, AK Nene, N Kannan, ...
PLoS biology 11 (10), e1001680, 2013
2142013
Kinase regulation by hydrophobic spine assembly in cancer
J Hu, LG Ahuja, HS Meharena, N Kannan, AP Kornev, SS Taylor, ...
Molecular and cellular biology 35 (1), 264-276, 2015
1062015
Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble
A Marco, HS Meharena, V Dileep, RM Raju, J Davila-Velderrain, ...
Nature neuroscience 23 (12), 1606-1617, 2020
1052020
A complex LuxR–LuxI type quorum sensing network in a roseobacterial marine sponge symbiont activates flagellar motility and inhibits biofilm formation
J Zan, EM Cicirelli, NM Mohamed, H Sibhatu, S Kroll, O Choi, CL Uhlson, ...
Molecular microbiology 85 (5), 916-933, 2012
952012
Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity
MB Victor, N Leary, X Luna, HS Meharena, AN Scannail, PL Bozzelli, ...
Cell Stem Cell 29 (8), 1197-1212. e8, 2022
902022
Pseudokinases from a structural perspective
SS Taylor, A Shaw, J Hu, HS Meharena, A Kornev
Biochemical Society Transactions 41 (4), 981-986, 2013
512013
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors
HS Meharena, A Marco, V Dileep, ER Lockshin, GY Akatsu, J Mullahoo, ...
Cell Stem Cell 29 (1), 116-130. e7, 2022
452022
Exploring the electron transfer properties of neuronal nitric-oxide synthase by reversal of the FMN redox potential
H Li, A Das, H Sibhatu, J Jamal, SG Sligar, TL Poulos
Journal of biological chemistry 283 (50), 34762-34772, 2008
422008
Evolution of a dynamic molecular switch
SS Taylor, HS Meharena, AP Kornev
IUBMB life 71 (6), 672-684, 2019
382019
Decoding the interactions regulating the active state mechanics of eukaryotic protein kinases
HS Meharena, X Fan, LG Ahuja, MM Keshwani, CL McClendon, AM Chen, ...
PLoS Biology 14 (11), e2000127, 2016
382016
Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence
MA Pence, NM Haste, HS Meharena, J Olson, RL Gallo, V Nizet, ...
PloS one 10 (8), e0136605, 2015
382015
Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration
V Dileep, CA Boix, H Mathys, A Marco, GM Welch, HS Meharena, A Loon, ...
Cell 186 (20), 4404-4421. e20, 2023
332023
A solo luxI-type gene directs acylhomoserine lactone synthesis and contributes to motility control in the marine sponge symbiont Ruegeria sp. KLH11
J Zan, O Choi, H Meharena, CL Uhlson, MEA Churchill, RT Hill, C Fuqua
Microbiology 161 (1), 50-56, 2015
222015
Defining the structure and function of acyl-homoserine lactone autoinducers
MEA Churchill, HM Sibhatu, CL Uhlson
Quorum Sensing: Methods and Protocols, 159-171, 2011
212011
From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome
LA Watson, HS Meharena
Frontiers in Genetics 14, 1198129, 2023
12023
Understanding redox regulation in membrane associated cytochrome P450s and the FMN domain of nitric oxide synthase
A Das, H Li, Y Grinkova, H Sibhatu, J Jamal, TL Poulos, SG Sligar
Chemical Research in Toxicology 23, 268-269, 2010
12010
Disruption of 3D-genome organization in neurodegeneration
V Dileep, A Marco, GM Welch, HS Meharena, LH Tsai
2021 Alzheimer's Association International Conference, 2021
2021
Evolution of a dynamic molecular switch.
AP Kornev, SS Taylor, HS Meharena
IUBMB Life 71 (6), 2019
2019
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