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Kai Kisand
Kai Kisand
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Year
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
P Bastard, LB Rosen, Q Zhang, E Michailidis, HH Hoffmann, Y Zhang, ...
Science 370 (6515), eabd4585, 2020
24072020
A dynamic COVID-19 immune signature includes associations with poor prognosis
AG Laing, A Lorenc, I Del Molino Del Barrio, A Das, M Fish, L Monin, ...
Nature medicine 26 (10), 1623-1635, 2020
9242020
Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines
K Kisand, AS Bøe Wolff, KT Podkrajšek, L Tserel, M Link, KV Kisand, ...
Journal of Experimental Medicine 207 (2), 299-308, 2010
7252010
Mapping the human genetic architecture of COVID-19
Writing group Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai ...
Nature 600 (7889), 472-477, 2021
7002021
Dynamics of antibody response to BNT162b2 vaccine after six months: a longitudinal prospective study
P Naaber, L Tserel, K Kangro, E Sepp, V Jürjenson, A Adamson, ...
The Lancet Regional Health–Europe 10, 2021
5522021
Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype
J Toubiana, S Okada, J Hiller, M Oleastro, M Lagos Gomez, ...
Blood, The Journal of the American Society of Hematology 127 (25), 3154-3164, 2016
4822016
Autoantibodies neutralizing type I IFNs are present in~ 4% of uninfected individuals over 70 years old and account for~ 20% of COVID-19 deaths
P Bastard, A Gervais, T Le Voyer, J Rosain, Q Philippot, J Manry, ...
Science immunology 6 (62), eabl4340, 2021
4222021
Assessment of interferon-related biomarkers in Aicardi-Goutieres syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study
GI Rice, GMA Forte, M Szynkiewicz, DS Chase, A Aeby, MS Abdel-Hamid, ...
The lancet neurology 12 (12), 1159-1169, 2013
4152013
X-linked recessive TLR7 deficiency in~ 1% of men under 60 years old with life-threatening COVID-19
T Asano, B Boisson, F Onodi, D Matuozzo, M Moncada-Velez, ...
Science immunology 6 (62), eabl4348, 2021
3162021
AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies
S Meyer, M Woodward, C Hertel, P Vlaicu, Y Haque, J Kärner, A Macagno, ...
Cell 166 (3), 582-595, 2016
2612016
Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1
P Bastard, E Orlova, L Sozaeva, R Lévy, A James, MM Schmitt, S Ochoa, ...
Journal of Experimental Medicine 218 (7), 2021
2272021
Whole-genome sequencing reveals host factors underlying critical COVID-19
A Kousathanas, E Pairo-Castineira, K Rawlik, A Stuckey, CA Odhams, ...
Nature 607 (7917), 97-103, 2022
2142022
MicroRNA expression profiles of human blood monocyte-derived dendritic cells and macrophages reveal miR-511 as putative positive regulator of Toll-like receptor 4
L Tserel, T Runnel, K Kisand, M Pihlap, L Bakhoff, R Kolde, H Peterson, ...
Journal of Biological Chemistry 286 (30), 26487-26495, 2011
1662011
Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes
L Tserel, R Kolde, M Limbach, K Tretyakov, S Kasela, K Kisand, M Saare, ...
Scientific reports 5 (1), 13107, 2015
1402015
Mucocutaneous candidiasis and autoimmunity against cytokines in APECED and thymoma patients: clinical and pathogenetic implications
K Kisand, D Lilic, JL Casanova, P Peterson, A Meager, N Willcox
European journal of immunology 41 (6), 1517-1527, 2011
1352011
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
J Manry, P Bastard, A Gervais, T Le Voyer, J Rosain, Q Philippot, ...
Proceedings of the National Academy of Sciences 119 (21), 2022
1242022
Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens
X Wang, M Laan, R Bichele, K Kisand, HS Scott, P Peterson
Frontiers in immunology 3, 14813, 2012
1242012
Modulation of Aire regulates the expression of tissue-restricted antigens
V Kont, M Laan, K Kisand, A Merits, HS Scott, P Peterson
Molecular immunology 45 (1), 25-33, 2008
1222008
Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genes
K Kisand, M Link, ASB Wolff, A Meager, L Tserel, T Org, A Murumägi, ...
Blood, The Journal of the American Society of Hematology 112 (7), 2657-2666, 2008
1202008
Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells
PL Poliani, K Kisand, V Marrella, M Ravanini, LD Notarangelo, A Villa, ...
The American journal of pathology 176 (3), 1104-1112, 2010
1122010
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