| Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions KG Roelofs, J Wang, HO Sintim, VT Lee Proceedings of the National Academy of Sciences 108 (37), 15528-15533, 2011 | 232 | 2011 |
| A computationally designed Rh (I)-catalyzed two-component [5+ 2+ 1] cycloaddition of ene-vinylcyclopropanes and CO for the synthesis of cyclooctenones Y Wang, J Wang, J Su, F Huang, L Jiao, Y Liang, D Yang, S Zhang, ... Journal of the American Chemical Society 129 (33), 10060-10061, 2007 | 196 | 2007 |
| Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules HO Sintim, JAI Smith, J Wang, S Nakayama, L Yan Future medicinal chemistry 2 (6), 1005-1035, 2010 | 183 | 2010 |
| Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover MW Orr, GP Donaldson, GB Severin, J Wang, HO Sintim, CM Waters, ... Proceedings of the National Academy of Sciences 112 (36), E5048-E5057, 2015 | 157 | 2015 |
| Essential roles of methionine and S-adenosylmethionine in the autarkic lifestyle of Mycobacterium tuberculosis M Berney, L Berney-Meyer, KW Wong, B Chen, M Chen, J Kim, J Wang, ... Proceedings of the National Academy of Sciences of the United States of …, 2015 | 135 | 2015 |
| Mechanistic studies of a small-molecule modulator of SMN2 splicing J Wang, PG Schultz, KA Johnson Proceedings of the National Academy of Sciences 115 (20), E4604-E4612, 2018 | 111 | 2018 |
| Thiazole orange-induced c-di-GMP quadruplex formation facilitates a simple fluorescent detection of this ubiquitous biofilm regulating molecule S Nakayama, I Kelsey, J Wang, K Roelofs, B Stefane, Y Luo, VT Lee, ... Journal of the American Chemical Society 133 (13), 4856-4864, 2011 | 92 | 2011 |
| Synthetic analogs tailor native AI-2 signaling across bacterial species V Roy, JAI Smith, J Wang, JE Stewart, WE Bentley, HO Sintim Journal of the American Chemical Society 132 (32), 11141-11150, 2010 | 92 | 2010 |
| DNA‐Based Peroxidation Catalyst—What Is the Exact Role of Topology on Catalysis and Is There a Special Binding Site for Catalysis? S Nakayama, J Wang, HO Sintim Chemistry–A European Journal 17 (20), 5691-5698, 2011 | 91 | 2011 |
| Rapamycin-inspired macrocycles with new target specificity Z Guo, SY Hong, J Wang, S Rehan, W Liu, H Peng, M Das, W Li, S Bhat, ... Nature chemistry 11 (3), 254-263, 2019 | 82 | 2019 |
| Conservative change to the phosphate moiety of cyclic diguanylic monophosphate remarkably affects its polymorphism and ability to bind DGC, PDE, and PilZ proteins J Wang, J Zhou, GP Donaldson, S Nakayama, L Yan, Y Lam, VT Lee, ... Journal of the American Chemical Society 133 (24), 9320-9330, 2011 | 66 | 2011 |
| c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators S Nakayama, I Kelsey, J Wang, HO Sintim Chemical Communications 47 (16), 4766-4768, 2011 | 60 | 2011 |
| Altering the communication networks of multispecies microbial systems using a diverse toolbox of AI-2 analogues S Gamby, V Roy, M Guo, JAI Smith, J Wang, JE Stewart, X Wang, ... ACS chemical biology 7 (6), 1023-1030, 2012 | 58 | 2012 |
| Effects on membrane lateral pressure suggest permeation mechanisms for bacterial quorum signaling molecules K Kamaraju, J Smith, J Wang, V Roy, HO Sintim, WE Bentley, S Sukharev Biochemistry 50 (32), 6983-6993, 2011 | 54 | 2011 |
| Potent suppression of c-di-GMP synthesis via I-site allosteric inhibition of diguanylate cyclases with 2′-Fc-di-GMP J Zhou, S Watt, J Wang, S Nakayama, DA Sayre, Y Lam, VT Lee, ... Bioorganic & medicinal chemistry 21 (14), 4396-4404, 2013 | 52 | 2013 |
| Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous JAI Smith, J Wang, SM Nguyen-Mau, V Lee, HO Sintim Chemical communications, 7033-7035, 2009 | 51 | 2009 |
| The RNA architecture of the SARS-CoV-2 3′-untranslated region J Zhao, J Qiu, S Aryal, JL Hackett, J Wang Viruses 12 (12), 1473, 2020 | 42 | 2020 |
| Remote C H Functionalization: Using the N O Moiety as an Atom‐Economical Tether to Obtain 1, 5‐and the Rare 1, 7‐C H Insertions J Wang, B Stefane, D Jaber, JAI Smith, C Vickery, M Diop, HO Sintim Angewandte Chemie International Edition 49 (23), 3964-3968, 2010 | 35 | 2010 |
| Discovery of a potent GLUT inhibitor from a library of rapafucins by using 3D microarrays Z Guo, Z Cheng, J Wang, W Liu, H Peng, Y Wang, AVS Rao, R Li, X Ying, ... Angewandte Chemie 131 (48), 17318-17322, 2019 | 29 | 2019 |
| Endo-Sc-di-GMP analogues-polymorphism and binding studies with class I riboswitch J Zhou, DA Sayre, J Wang, N Pahadi, HO Sintim Molecules 17 (11), 13376-13389, 2012 | 29 | 2012 |
Herman O. SintimRichard B. Wetherill Distinguished Professor, Purdue UniversityVerified email at purdue.edu
