I Sadaf Farooqi
I Sadaf Farooqi
Professor of Metabolism and Medicine, University of Cambridge
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Congenital leptin deficiency is associated with severe early-onset obesity in humans
CT Montague, IS Farooqi, JP Whitehead, MA Soos, H Rau, NJ Wareham, ...
Nature 387 (6636), 903-907, 1997
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
EK Speliotes, CJ Willer, SI Berndt, KL Monda, G Thorleifsson, AU Jackson, ...
Nature genetics 42 (11), 937-948, 2010
Effects of recombinant leptin therapy in a child with congenital leptin deficiency
IS Farooqi, SA Jebb, G Langmack, E Lawrence, CH Cheetham, ...
New England Journal of Medicine 341 (12), 879-884, 1999
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
CJ Willer, EK Speliotes, RJF Loos, S Li, CM Lindgren, IM Heid, SI Berndt, ...
Nature genetics 41 (1), 25-34, 2009
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
IS Farooqi, G Matarese, GM Lord, JM Keogh, E Lawrence, C Agwu, ...
The Journal of clinical investigation 110 (8), 1093-1103, 2002
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
IS Farooqi, JM Keogh, GSH Yeo, EJ Lank, T Cheetham, S O'Rahilly
New England Journal of Medicine 348 (12), 1085-1095, 2003
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
T Gerken, CA Girard, YCL Tung, CJ Webby, V Saudek, KS Hewitson, ...
Science 318 (5855), 1469-1472, 2007
Common variants near MC4R are associated with fat mass, weight and risk of obesity
RJF Loos, CM Lindgren, S Li, E Wheeler, JH Zhao, I Prokopenko, ...
Nature genetics 40 (6), 768-775, 2008
A frameshift mutation in MC4R associated with dominantly inherited human obesity
GSH Yeo, IS Farooqi, S Aminian, DJ Halsall, RG Stanhope, S O'Rahilly
Nature genetics 20 (2), 111-112, 1998
Genetics of body-weight regulation
GS Barsh, IS Farooqi, S O'Rahilly
Nature 404 (6778), 644-651, 2000
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
IS Farooqi, GSH Yeo, JM Keogh, S Aminian, SA Jebb, G Butler, ...
The Journal of clinical investigation 106 (2), 271-279, 2000
Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor
IS Farooqi, T Wangensteen, S Collins, W Kimber, G Matarese, JM Keogh, ...
New England Journal of Medicine 356 (3), 237-247, 2007
Genetics of obesity in humans
IS Farooqi, S O’Rahilly
Endocrine reviews 27 (7), 710-718, 2006
The hormonal control of food intake
AP Coll, IS Farooqi, S O'Rahilly
Cell 129 (2), 251-262, 2007
Leptin regulates striatal regions and human eating behavior
IS Farooqi, E Bullmore, J Keogh, J Gillard, S O'Rahilly, PC Fletcher
Science 317 (5843), 1355-1355, 2007
Large, rare chromosomal deletions associated with severe early-onset obesity
EG Bochukova, NI Huang, J Keogh, E Henning, C Purmann, K Blaszczyk, ...
Nature 463 (7281), 666-670, 2010
Obesity associated genetic variation in FTO is associated with diminished satiety
J Wardle, S Carnell, CMA Haworth, IS Farooqi, S O'Rahilly, R Plomin
The Journal of Clinical Endocrinology & Metabolism 93 (9), 3640-3643, 2008
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
GSH Yeo, CCC Hung, J Rochford, J Keogh, J Gray, S Sivaramakrishnan, ...
Nature neuroscience 7 (11), 1187-1189, 2004
Monogenic obesity in humans
IS Farooqi, S O'Rahilly
Annu. Rev. Med. 56, 443-458, 2005
A new highly penetrant form of obesity due to deletions on chromosome 16p11. 2
RG Walters, S Jacquemont, A Valsesia, AJ De Smith, D Martinet, ...
Nature 463 (7281), 671-675, 2010
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