| Epigenetic protein families: a new frontier for drug discovery CH Arrowsmith, C Bountra, PV Fish, K Lee, M Schapira Nature Reviews Drug Discovery 11 (5), 384-400, 2012 | 1562 | 2012 |
| Bridging solubility between drug discovery and development L Di, PV Fish, T Mano Drug Discovery Today 17 (9/10), 486, 2012 | 512 | 2012 |
| PFI-1: A highly Selective Protein Interaction Inhibitor Targeting BET Bromodomains. S Picaud, D Da Costa, A Thanasopoulou, P Filippakopoulos, PV Fish, ... Cancer Research 73, 3336, 2013 | 288 | 2013 |
| Identification of a chemical probe for BET bromodomain inhibition through optimization of a fragment-derived hit PV Fish, P Filippakopoulos, G Bish, P Brennan, ME Bunnage, A Cook, ... Journal of Medicinal Chemistry 55 (22), 9831, 2012 | 251 | 2012 |
| The Scar‐in‐a‐Jar: studying potential antifibrotic compounds from the epigenetic to extracellular level in a single well CZC Chen, YX Peng, ZB Wang, PV Fish, JL Kaar, RR Koepsel, AJ Russell, ... British journal of pharmacology 158 (5), 1196-1209, 2009 | 191 | 2009 |
| (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells D Barsyte-Lovejoy, F Li, MJ Oudhoff, JH Tatlock, A Dong, H Zeng, H Wu, ... Proceedings of the National Academy of Sciences 111 (35), 12853, 2014 | 181 | 2014 |
| New Approaches for the Treatment of Alzheimer’s Disease PV Fish, D Steadman, ED Bayle, P Whiting Bioorganic & Medicinal Chemistry Letters 29 (2), 125-133, 2019 | 156 | 2019 |
| Predicting Penetration across the blood-brain barrier from simple descriptors and fragmental schemes YH Zhao, MA Abraham, A Ibrahim, PV Fish, S Cole, ML Lewis, ... J. Chem. Inf. Model. 47 (1), 170-175, 2007 | 155 | 2007 |
| NOTUM from Apc-mutant cells biases clonal competition to initiate cancer DJ Flanagan, N Pentinmikko, K Luopajärvi, NJ Willis, K Gilroy, AP Raven, ... Nature 594, 430-435, 2021 | 140 | 2021 |
| Inhibit Procollagen C-proteinase; antiscarring treatment for wounds. S Bailey, S Billotte, P Fish, K James, N Thomson, A Derrick US Patent App. 10/198,710, 2002 | 125* | 2002 |
| The first examples of nonenzymic, biomimetic polyene pentacyclizations. Total synthesis of the pentacyclic triterpenoid sophoradiol PV Fish, WS Johnson The Journal of Organic Chemistry 59 (9), 2324-2335, 1994 | 107 | 1994 |
| Directing Differentiation of Human Embryonic Stem Cells Toward Anterior Neural Ectoderm Using Small Molecules B Surmacz, H Fox, A Gutteridge, P Fish, S Lubitz, P Whiting Stem Cells 30 (9), 1875-1884, 2012 | 93 | 2012 |
| Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl) guanidines PV Fish, CG Barber, DG Brown, R Butt, MG Collis, RP Dickinson, ... Journal of medicinal chemistry 50 (10), 2341-2351, 2007 | 76 | 2007 |
| Potent and selective nonpeptidic inhibitors of procollagen C-proteinase PV Fish, GA Allan, S Bailey, J Blagg, R Butt, MG Collis, D Greiling, ... Journal of medicinal chemistry 50 (15), 3442-3456, 2007 | 73 | 2007 |
| UCT943, a next generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria C Brunschwig, N Lawrence, D Taylor, E Abay, M Njoroge, GS Basarab, ... Antimicrobial Agents and Chemotherapy, AAC. 00012-18, 2018 | 62 | 2018 |
| Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors K Devkota, M Schapira, S Perveen, AK Yazdi, F Li, I Chau, P Ghiabi, ... SLAS Discovery 26 (9), 1200, 2021 | 59 | 2021 |
| Comprises a growth factor and an enzyme inhibitor for a specific adverse enzyme that is upregulated in the environment of a damaged tissue; wound healing agents; antiulcer … K Dack, M Davies, P Fish, J Huggins, F McIntosh, N Occleston US Patent App. 10/131,985, 2002 | 57* | 2002 |
| Novel heterocyclic compounds as bromodomain inhibitors PV Fish, A Cook, C Phillips, A Bent, J Mills, N Sciammetta WO Patent 2013/027,168, 2013 | 54* | 2013 |
| Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies N Igoe, ED Bayle, O Fedorov, C Tallant, P Savitsky, C Rogers, DR Owen, ... Journal of Medicinal Chemistry 60, 668-680, 2017 | 49 | 2017 |
| Epoxide-initiated cationic polyene cyclisations PV Fish, AR Sudhakar, WS Johnson Tetrahedron letters 34 (49), 7849-7852, 1993 | 46 | 1993 |
