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Ludovic Halby
Ludovic Halby
CNRS/Pasteur
Adresse e-mail validée de cnrs.fr
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The triple helix: 50 years later, the outcome
M Duca, P Vekhoff, K Oussedik, L Halby, PB Arimondo
Nucleic acids research 36 (16), 5123-5138, 2008
3642008
DNA methylation inhibitors in cancer: recent and future approaches
C Gros, J Fahy, L Halby, I Dufau, A Erdmann, JM Gregoire, F Ausseil, ...
Biochimie 94 (11), 2280-2296, 2012
2452012
Targeting DNA methylation with small molecules: what’s next? Miniperspective
A Erdmann, L Halby, J Fahy, PB Arimondo
Journal of medicinal chemistry 58 (6), 2569-2583, 2015
1112015
DNA methylation targeting: the DNMT/HMT crosstalk challenge
O Castillo-Aguilera, P Depreux, L Halby, PB Arimondo, L Goossens
Biomolecules 7 (1), 3, 2017
1072017
Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates
PB Arimondo, CJ Thomas, K Oussedik, B Baldeyrou, C Mahieu, L Halby, ...
Molecular and cellular biology 26 (1), 324-333, 2006
812006
Rapid synthesis of new DNMT inhibitors derivatives of procainamide
L Halby, C Champion, C Sénamaud‐Beaufort, S Ajjan, T Drujon, ...
Chembiochem 13 (1), 157-165, 2012
612012
Towards the sustainable discovery and development of new antibiotics
M Miethke, M Pieroni, T Weber, M Brönstrup, P Hammann, L Halby, ...
Nature Reviews Chemistry 5 (10), 726-749, 2021
562021
Sequence‐Specific Conjugates of Oligo(2′‐O‐methylribonucleotides) and Hairpin Oligocarboxamide Minor‐Groove Binders: Design, Synthesis, and Binding …
DS Novopashina, AN Sinyakov, VA Ryabinin, AG Venyaminova, L Halby, ...
Chemistry & Biodiversity 2 (7), 936-952, 2005
412005
Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides
M Duca, D Guianvarc'h, K Oussedik, L Halby, A Garbesi, D Dauzonne, ...
Nucleic acids research 34 (6), 1900-1911, 2006
392006
Sequence-specific DNA cleavage mediated by bipyridine polyamide conjugates
P Simon, F Cannata, L Perrouault, L Halby, JP Concordet, A Boutorine, ...
Nucleic acids research 36 (11), 3531-3538, 2008
372008
Functionalized head-to-head hairpin polyamides: Synthesis, double-stranded DNA-binding activity and affinity
L Halby, VA Ryabinin, AN Sinyakov, AS Boutorine
Bioorganic & medicinal chemistry letters 15 (16), 3720-3724, 2005
332005
Rational design of bisubstrate-type analogues as inhibitors of DNA methyltransferases in cancer cells
L Halby, Y Menon, E Rilova, D Pechalrieu, V Masson, C Faux, MA Bouhlel, ...
Journal of Medicinal Chemistry 60 (11), 4665-4679, 2017
312017
Single-molecule observations of topotecan-mediated TopIB activity at a unique DNA sequence
DA Koster, F Czerwinski, L Halby, A Crut, P Vekhoff, K Palle, PB Arimondo, ...
Nucleic acids research 36 (7), 2301-2310, 2008
232008
DNA methyltransferase inhibitors: development and applications
M Lopez, L Halby, PB Arimondo
DNA Methyltransferases-Role and Function, 431-473, 2016
222016
The past and presence of gene targeting: from chemicals and DNA via proteins to RNA
TM Geel, MHJ Ruiters, RH Cool, L Halby, DC Voshart, L Andrade Ruiz, ...
Philosophical Transactions of the Royal Society B: Biological Sciences 373 …, 2018
202018
Design and synthesis of new non nucleoside inhibitors of DNMT3A
A Erdmann, Y Menon, C Gros, N Molinier, N Novosad, A Samson, ...
Bioorganic & Medicinal Chemistry 23 (17), 5946-5953, 2015
182015
Sequence‐specific targeting of IGF‐I and IGF‐IR genes by camptothecins
K Oussedik, JC François, L Halby, C Senamaud‐Beaufort, G Toutirais, ...
The FASEB Journal 24 (7), 2235-2244, 2010
182010
Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors
L Halby, N Marechal, D Pechalrieu, V Cura, DM Franchini, C Faux, F Alby, ...
Philosophical Transactions of the Royal Society B: Biological Sciences 373 …, 2018
162018
Activation of camptothecin derivatives by conjugation to triple helix-forming oligonucleotides
PB Arimondo, GS Laco, CJ Thomas, L Halby, D Pez, P Schmitt, ...
Biochemistry 44 (11), 4171-4180, 2005
162005
Targeting MDR1 gene: synthesis and cellular study of modified daunomycin-triplex-forming oligonucleotide conjugates able to inhibit gene expression in resistant cell lines
V Stierlé, M Duca, L Halby, C Senamaud-Beaufort, ML Capobianco, ...
Molecular Pharmacology 73 (5), 1568-1577, 2008
152008
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